Results 51 to 60 of about 5,697,775 (262)
Proximity-Dependent Biotinylation and Identification of Flagellar Proteins in Trypanosoma cruzi
mSphere, 2023 The flagellated kinetoplastid protozoan and causative agent of human Chagas disease, Trypanosoma cruzi, inhabits both invertebrate and mammalian hosts over the course of its complex life cycle. In these disparate environments, T.
Madalyn M. Won +2 more
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The proteasome as a target for protozoan parasites
Expert opinion on therapeutic targets, 2019 Introduction: The proteasome is a multi-subunit enzyme complex responsible for the turnover of short-lived, abnormal or damaged proteins in eukaryotic cells. As organisms that undergo rapid growth and cell division, protozoan parasites exist on the knife-
S. Xie +4 more
semanticscholar +1 more source
Structural Basis of Parasitic HSP90 ATPase Inhibition by Small Molecules
Pharmaceuticals, 2022 Protozoan parasites are responsible for several harmful and widespread human diseases that cause high morbidity and mortality. Currently available treatments have serious limitations due to poor efficiency, strong adverse effects, and high cost.
Giusy Tassone +2 more
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The EhCPADH112 complex of Entamoeba histolytica interacts with tight junction proteins occludin and claudin-1 to produce epithelial damage. [PDF]
PLoS ONE, 2013 Entamoeba histolytica, the protozoan responsible for human amoebiasis, causes between 30,000 and 100,000 deaths per year worldwide. Amoebiasis is characterized by intestinal epithelial damage provoking severe diarrhea.
Abigail Betanzos +6 more
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Role of Leukotrienes on Protozoan and Helminth Infections
Mediators of Inflammation, 2012 Leukotrienes (LTs), formed by the 5-lipoxygenase-(5-LO-) catalyzed oxidation of arachidonic acid, are lipid mediators that have potent proinflammatory activities.
Alexandre P. Rogerio, Fernanda F. Anibal
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The Lipid Raft Proteome of African Trypanosomes Contains Many Flagellar Proteins
Pathogens, 2017 Lipid rafts are liquid-ordered membrane microdomains that form by preferential association of 3-β-hydroxysterols, sphingolipids and raft-associated proteins often having acyl modifications.
Aabha I. Sharma +2 more
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Frontiers in Immunology, 2020 Chagas disease, a zoonosis caused by the flagellate protozoan Trypanosoma cruzi, is a chronic and systemic parasitic infection that affects ~5–7 million people worldwide, mainly in Latin America. Chagas disease is an emerging public health problem due to
Renata Watanabe Costa +13 more
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Frontiers in Cell and Developmental Biology, 2022 Plasmodium falciparum is a unicellular protozoan parasite and causative agent of the most severe form of malaria in humans. The malaria parasite has had to develop sophisticated mechanisms to preserve its proteome under the changing stressful conditions ...
Gregory L. Blatch +2 more
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International Journal of Molecular Sciences, 2019 Obligate protozoan parasites of the kinetoplastids and apicomplexa infect human cells to complete their life cycles. Some of the members of these groups of parasites develop in at least two systems, the human host and the insect vector.
T. Zininga, A. Shonhai
semanticscholar +1 more source
Frontiers in Cellular and Infection Microbiology, 2022 Autophagy is one of the bulk degradation systems and is conserved throughout eukaryotes. In the enteric protozoan parasite Entamoeba histolytica, the causative agent of human amebiasis, Atg8 is not exclusively involved in autophagy per se but also in ...
Kumiko Nakada-Tsukui +5 more
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