Results 61 to 70 of about 93 (92)

CXCL10highTNFαhighKi67+ Microglia Recruit and Activate CD8+ T Cells in the Brainstem During Experimental Cerebral Malaria

open access: yesCNS Neuroscience &Therapeutics, Volume 31, Issue 6, June 2025.
Microglia exhibit distinct transcriptional and morphological heterogeneity in experimental cerebral malaria (ECM) compared to physiological microglia. A unique subtype of ECM‐associated microglia, characterized by CXCL10highTNFαhighKi67+, mediates the recruitment and sustained activation of CD8+ T cells through ongoing interactions, exacerbating ...
Yi Wang   +13 more
wiley   +1 more source

Adaptation of Marine Heterotrophic Protists to Long‐Term Warming Selection

open access: yesGlobal Change Biology, Volume 31, Issue 6, June 2025.
Our study unraveled profitable adaptations of marine protozoa to long‐term warming. The optimal temperature, maximum growth rates, cell homeostasis, and cell size significantly increased after warming adaptation, suggesting a resilient future for this functional group.
Mengwen Pang   +7 more
wiley   +1 more source

Cytotoxic Signature and IFN‐γ Production Dominate CD4+ T‐Cell Response During Human Toxoplasmosis

open access: yesImmunology, Volume 175, Issue 2, Page 151-164, June 2025.
Overview of CD4+ T‐cell subsets in patients with toxoplasmosis. Schematic drawing summarising the most important alterations in CD4+ T‐cell subsets, illustrated in different colours, from patients in distinct stages of toxoplasmosis, represented with different colours, with (lesion) or without (no lesion) ocular manifestations.
Priscilla Miranda Henriques   +14 more
wiley   +1 more source

Flavodiiron proteins associate pH‐dependently with the thylakoid membrane for ferredoxin‐1‐powered O2 photoreduction

open access: yesNew Phytologist, Volume 246, Issue 5, Page 2084-2101, June 2025.
Summary Flavodiiron proteins (FDPs) catalyse light‐dependent reduction of oxygen to water in photosynthetic organisms, creating an electron sink on the acceptor side of Photosystem I that protects the photosynthetic apparatus. However, ambiguity about the electron donor(s) remains, and the molecular mechanisms regulating FDP activity have remained ...
Lauri Nikkanen   +9 more
wiley   +1 more source

Profiling Serine Hydrolases in the Leishmania Host–Pathogen Interactome Using Cell‐Permeable Activity‐Based Fluorophosphonate Probes

open access: yesChemBioChem, Volume 26, Issue 10, May 27, 2025.
Leishmaniasis poses a global health challenge with limited treatment options and rising drug resistance. Activity‐based protein profiling using fluorophosphonate probes is employed to profile serine hydrolases, key virulence factors in Leishmania mexicana.
Jaime A. Isern   +7 more
wiley   +1 more source

Chemical Protein Engineering: Backbone Cyclization Rescues Folding of a 183‐Residue Truncated Domain of Malaria Parasite Protein PfAMA1

open access: yesChemistry – A European Journal, Volume 31, Issue 28, May 19, 2025.
We report the first chemical synthesis of a 183‐residue functional truncated cyclic PfAMA1 domain I protein using multi‐segment native chemical ligation and head‐to‐tail cyclization to introduce conformational constraints, thereby facilitating protein folding and providing novel strategies for miniature protein engineering.
Jamsad Mannuthodikayil   +4 more
wiley   +1 more source

The role of Mob proteins in protozoan cell cycle regulation.

open access: yes, 2015
RESUMO - O papel das proteínas Mob1 na regulação da divisão celular em protozoários - A divisão celular e o controlo da proliferação são aspectos fundamentais em biologia celular com implicações no desenvolvimento embrionário e na manutenção da homeostasia nos organismos.
openaire   +2 more sources

Diversity Functions of Puf Proteins in Protozoan Species

open access: yesInternational Journal of Zoology and Animal Biology, 2018
openaire   +1 more source

Protozoan protein tyrosine phosphatases

International Journal for Parasitology, 2008
The aim of this review is to provide a synthesis of the published experimental data on protein tyrosine phosphatases from parasitic protozoa, in silico analysis based on the availability of completed genomes and to place available data for individual phosphatases from different unicellular parasites into the comparative and evolutionary context.
Alexandra V. Andreeva   +1 more
openaire   +3 more sources

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