Ultrastructural identification of developing proximal tubules based on three‐dimensional reconstruction [PDF]
Veterinary Medicine and Science, 2021 Background The cellular mechanisms involved in the development of proximal tubules are not only associated with morphogenesis in fetal life, but also with restoration of damaged tubules in adulthood.
Jing Cong +8 more
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Light Chain Restriction in Proximal Tubules—Implications for Light Chain Proximal Tubulopathy [PDF]
Frontiers in Medicine, 2022 Monoclonal gammopathy (MG) causes various nephropathies, which may suffice for cytoreductive therapy even in the absence of diagnostic criteria for multiple myeloma or B-cell non-Hodgkin lymphoma.
Maike Büttner-Herold +11 more
doaj +2 more sources
CaOx crystal nuclei are formed in rat outer cortex proximal tubules by a potential fibrinogen-dependent mechanism. [PDF]
PLoS ONECalcium oxalate (CaOx) stones are prevalent in urinary tract stone disease. While their formation can be induced in rats by administering ethylene glycol and vitamin D, the initial nucleation and formation processes are unclear.
Kenshirou Kunii +13 more
doaj +2 more sources
Tubulointerstitial injury and proximal tubule albumin transport in early diabetic nephropathy induced by type 1 diabetes mellitus [PDF]
, 2017 A decrease in the tubular expression of albumin endocytic transporters megalin and cubilin has been associated with diabetic nephropathy (DN), but there are no comprehensive studies to date relating early tubulointerstitial injury and the effect of the ...
Bahamonde, Javiera +3 more
core +2 more sources
Age-related TFEB downregulation in proximal tubules causes systemic metabolic disorders and occasional apolipoprotein A4–related amyloidosis [PDF]
JCI InsightWith the aging of society, the incidence of chronic kidney disease (CKD), a common cause of death, has been increasing. Transcription factor EB (TFEB), the master transcriptional regulator of the autophagy/lysosomal pathway, is regarded as a promising ...
Jun Nakamura +20 more
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Proximal tubules eliminate endocytosed gold nanoparticles through an organelle-extrusion-mediated self-renewal mechanism [PDF]
Nature Nanotechnology, 2023 Jie Zheng
exaly +2 more sources
mutation: a benign genetic cause of proteinuria? [PDF]
Childhood Kidney Diseases, 2023 Proteinuria is an important risk factor for renal and cardiovascular disease. It is associated with a risk for glomerulonephritis, chronic kidney disease, and end-stage renal disease.
Hyun Kyung Lee
doaj +1 more source
Generation and characterization of an inducible renal proximal tubule-specific CreERT2 mouse
Frontiers in Cell and Developmental Biology, 2023 Protein reabsorption in renal proximal tubules is essential for maintaining nutrient homeostasis. Renal proximal tubule-specific gene knockout is a powerful method to assess the function of genes involved in renal proximal tubule protein reabsorption ...
Shiting Liang +7 more
doaj +1 more source
Light chain proximal tubulopathy with lambda restriction presenting as acute kidney injury [PDF]
Journal of Nephropathology, 2021 Monoclonal gammopathies can produce a variety of glomerular, tubular, vascular and interstitial lesions. The spectrums of renal lesions produced by these monoclonal gammopathies include AL/AH amyloidosis, light chain cast nephropathy or myeloma kidney ...
Asha Thomas +4 more
doaj +1 more source
Retinoic acid receptor α activity in proximal tubules prevents kidney injury and fibrosis. [PDF]
Proc Natl Acad Sci U S ADiKun KM +5 more
europepmc +3 more sources