Results 1 to 10 of about 6,919 (146)

Novel anti-prion compounds screening in prion-infected cell culture model combined with surface plasmon resonance analysis [PDF]

Scientific Reports
Prions are misfolded proteins (PrPSc) capable of inducing the same conformational change in normal prion proteins (PrPC). These aberrant proteins are responsible for neurodegenerative diseases in animals and humans, for which no effective treatments ...
Mai Hazekawa, Daisuke Ishibashi, Andrea Altieri, Evgeniy A. Spiridonov, Nikolai A. Dmitriev, Evgeny R. Lukyanenko, Emiliano Biasini, Alexander V. Kurkin   +7 more
doaj   +2 more sources

The Expression of Cellular Prion Protein, PrPC, Favors pTau Propagation and Blocks NMDAR Signaling in Primary Cortical Neurons

Cells, 2023
Background: The N-methyl-D-aspartate receptor (NMDAR) is a target in current treatments for Alzheimer’s disease (AD). The human prion protein (PrPC) has an important role in the pathophysiology of AD.
Rafael Rivas-Santisteban, Iu Raïch, David Aguinaga, Carlos A. Saura, Rafael Franco, Gemma Navarro   +5 more
doaj   +1 more source

Copper and Zinc Interactions with Cellular Prion Proteins Change Solubility of Full-Length Glycosylated Isoforms and Induce the Occurrence of Heterogeneous Phenotypes. [PDF]

PLoS ONE, 2016
Prion diseases are characterized biochemically by protein aggregation of infectious prion isoforms (PrPSc), which result from the conformational conversion of physiological prion proteins (PrPC).
Svetlana Brim, Martin H Groschup, Thorsten Kuczius   +2 more
doaj   +1 more source

Inducing prion protein shedding as a neuroprotective and regenerative approach in pathological conditions of the brain: from theory to facts

Neural Regeneration Research, 2023
In the last decades, the role of the prion protein (PrP) in neurodegenerative diseases has been intensively investigated, initially in prion diseases of humans (e.g., Creutzfeldt-Jakob disease) and animals (e.g., scrapie in sheep, chronic wasting disease
Andreu Matamoros-Angles, Behnam Mohammadi, Feizhi Song, Mohsin Shafiq, Santra Brenna, Berta Puig, Markus Glatzel, Hermann C Altmeppen   +7 more
doaj   +1 more source

PrPC as a Transducer of Physiological and Pathological Signals

Frontiers in Molecular Neuroscience, 2021
After the discovery of prion phenomenon, the physiological role of the cellular prion protein (PrPC) remained elusive. In the past decades, molecular and cellular analysis has shed some light regarding interactions and functions of PrPC in health and ...
Jessica D. Panes, Paulina Saavedra, Paulina Saavedra, Benjamin Pineda, Kathleen Escobar, Kathleen Escobar, Magdalena E. Cuevas, Gustavo Moraga-Cid, Jorge Fuentealba, Coralia I. Rivas, Human Rezaei, Human Rezaei, Human Rezaei, Carola Muñoz-Montesino   +13 more
doaj   +1 more source

The Cellular Prion Protein—ROCK Connection: Contribution to Neuronal Homeostasis and Neurodegenerative Diseases

Frontiers in Cellular Neuroscience, 2021
Amyloid-based neurodegenerative diseases such as prion, Alzheimer's, and Parkinson's diseases have distinct etiologies and clinical manifestations, but they share common pathological events.
Benoit Schneider, Benoit Schneider, Anne Baudry, Anne Baudry, Mathéa Pietri, Mathéa Pietri, Aurélie Alleaume-Butaux, Aurélie Alleaume-Butaux, Aurélie Alleaume-Butaux, Chloé Bizingre, Chloé Bizingre, Pierre Nioche, Pierre Nioche, Pierre Nioche, Odile Kellermann, Odile Kellermann, Jean-Marie Launay, Jean-Marie Launay   +17 more
doaj   +1 more source

PrPC Directly Interacts with Proteins Involved in Signaling Pathways [PDF]

Journal of Biological Chemistry, 2001
The cellular prion protein (PrP(C)) is a conserved glycoprotein predominantly expressed in neuronal cells. Its purpose in living cells is still enigmatic. To elucidate on its cellular function, we performed a yeast two-hybrid screen for interactors.
C, Spielhaupter, H M, Schätzl
openaire   +2 more sources

Treatment of microglia with Anti-PrP monoclonal antibodies induces neuronal apoptosis in vitro

Heliyon, 2021
Previous reports highlighted the neurotoxic effects caused by some motif-specific anti-PrPC antibodies in vivo and in vitro. In the current study, we investigated the detailed alterations of the proteome with liquid chromatography–mass spectrometry ...
Utpal Kumar Adhikari, Elif Sakiz, Umma Habiba, Meena Mikhael, Matteo Senesi, Monique Antoinette David, Gilles J. Guillemin, Lezanne Ooi, Tim Karl, Steven Collins, Mourad Tayebi   +10 more
doaj   +1 more source

Cross-Linking Cellular Prion Protein Induces Neuronal Type 2-Like Hypersensitivity

Frontiers in Immunology, 2021
BackgroundPrevious reports identified proteins associated with ‘apoptosis’ following cross-linking PrPC with motif-specific anti-PrP antibodies in vivo and in vitro.
Utpal Kumar Adhikari, Elif Sakiz, Xian Zhou, Umma Habiba, Sachin Kumar, Meena Mikhael, Matteo Senesi, Matteo Senesi, Chun Guang Li, Gilles J. Guillemin, Lezanne Ooi, Lezanne Ooi, Monique Antoinette David, Steven Collins, Steven Collins, Tim Karl, Tim Karl, Tim Karl, Mourad Tayebi   +18 more
doaj   +1 more source

Cellular prion protein (PrPC) in the development of Merlin-deficient tumours [PDF]

Oncogene, 2017
Loss of function mutations in the neurofibromatosis Type 2 (NF2) gene, coding for a tumour suppressor, Merlin, cause multiple tumours of the nervous system such as schwannomas, meningiomas and ependymomas. These tumours may occur sporadically or as part of the hereditary condition neurofibromatosis Type 2 (NF2). Current treatment is confined to (radio)
Provenzano, L, Ryan, Y, Hilton, DA, Lyons-Rimmer, J, Dave, F, Maze, EA, Adams, CL, Rigby-Jones, R, Ammoun, S, Hanemann, CO   +9 more
openaire   +3 more sources