Results 151 to 160 of about 6,958 (184)

The normal cellular prion protein (PrPc) is strongly expressed in bovine endocrine pancreas

Histochemistry and Cell Biology, 2005
Expression of the cellular prion protein (PrP(c)) has been shown to be crucial for the development of transmissible spongiform encephalopathies and for the accumulation of the disease-associated conformer (PrP(sc)) in the brain and other tissues. One of the emerging hypotheses is that the conversion phenomenon could take place at the site where the ...
W M, Amselgruber, M, Büttner, T, Schlegel, M, Schweiger, E, Pfaff   +4 more
openaire   +2 more sources

Different levels of prion protein (PrPc) expression on hamster, mouse and human blood cells

British Journal of Haematology, 2000
The host prion protein, PrPc, and its conformationally changed isoform, PrPsc, play an essential role in the transmissible spongiform encephalopathy (TSE) infections. The prion hypothesis postulates that PrPsc is the TSE infectious agent and that it serves as a template to convert host PrPc to additional PrPsc.
K, Holada, J G, Vostal
openaire   +2 more sources

Physiological role of the normal cellular prion protein (PrPC)

2014
na
Govindarajan, Nambirajan, Fischer, Andre, Zerr, Inga   +2 more
openaire  

[Cloning and sequencing of the Chinese bovine prion protein (PrPC) gene].

Wei sheng wu xue bao = Acta microbiologica Sinica, 2003
The total DNA was isolated from lymphocyte of peripheral blood of Chinese cattle. The PrPC gene was amplified by polymerase chain reaction, using two primers. It was then cloned into pGEM-T Easy Vector. The result of DNA sequencing was indicated that the 795 bp amplified fragment contains the entire PrPC coding sequence, which has no intron and is same
D, Wang, X, Wang, S, Han, B, Tian, Z, Rao   +4 more
openaire   +1 more source

Mapping the interactions between prion protein (PrPC) and prion protein fibrils (PrPSc)

Biophysical Journal, 2023
Alyssa M. Thallemer, Linh Bui, Patricia Soto   +2 more
openaire   +1 more source

[Study on the correlation between membrane protein Flotillin-1 and PrPc endocytosis].

Zhonghua shi yan he lin chuang bing du xue za zhi = Zhonghua shiyan he linchuang bingduxue zazhi = Chinese journal of experimental and clinical virology, 2013
To explore whether the membrane-associated protein Flotillin-1 has relationship with endocytosis of PrPc.The expression of Flotillin-1 in different cell lines was detected with the method of Western Blot; the interaction between Flotillin-1 and PrPc in Cells which were treated with copper ions was observed using immunoprecipitation method.(1) Flotillin-
Ke, Ren, Ke, Wang, Yin, Xu, Long-Zhu, Li, Jin, Zhang, Hui, Wang, Yu-E, Yan, Xiao-Ping, Dong, Chen, Gao   +8 more
openaire   +1 more source

T lymphocyte activation and the cellular form of the prion protein, PrPc

Biochemical Society Transactions, 1997
N A, Mabbott, K L, Brown, M E, Bruce
  +5 more sources

Integrative oncology: Addressing the global challenges of cancer prevention and treatment

Ca-A Cancer Journal for Clinicians, 2022
Jun J Mao,, Msce, Lorenzo Cohen, Karen M Mustian   +2 more
exaly  

Glycan chains of Prion protein PrPc affect its metal ion-binding-activity

2005
PrPc is the normal isoform of the prion protein PrP, which can be converted into PrPsc, the pathology-associated conformer in TSE. PrPc contains two N-linked glycan chains located on the C-proximal globular domain. Although the PrPc functions are still unknown, its ability to bind Cu++ is well documented. The main Cu++-binding sites have been mapped to
Moudjou, Mohammed, Bernard, Julie, Langevin, Christelle, Eghiaian, Frédéric, Rezaei, Human, Vilette, Didier, Laude, Hubert   +6 more
openaire   +2 more sources

Obesity and adverse breast cancer risk and outcome: Mechanistic insights and strategies for intervention

Ca-A Cancer Journal for Clinicians, 2017
Cynthia Morata-Tarifa, Joyce M Slingerland   +1 more
exaly