Results 11 to 20 of about 6,958 (184)

Strain Traits of Intracranially Administered L-Type Bovine Spongiform Encephalopathy Prions Are not Significantly Modified During Intraspecies Transmission in Cynomolgus Monkeys. [PDF]

Microbiol Immunol
ABSTRACT Among the three prion strains of bovine spongiform encephalopathy (BSE), classical BSE (C‐BSE) prions are known causative agents of variant Creutzfeldt–Jakob disease. By contrast, human infections with L‐type (L‐) or H‐type (H‐) BSE prions have not been reported.
Hagiwara K, Shibata H, Tobiume M, Sato Y, Ohto K, Okabayashi S, Nakano N, Horiuchi M, Ono F.   +8 more
europepmc   +2 more sources

Autophagy Activation Associates with Suppression of Prion Protein and Improved Mitochondrial Status in Glioblastoma Cells

Cells, 2023
Cells from glioblastoma multiforme (GBM) feature up-regulation of the mechanistic Target of Rapamycin (mTOR), which brings deleterious effects on malignancy and disease course.
Paola Lenzi, Carla L. Busceti, Gloria Lazzeri, Rosangela Ferese, Francesca Biagioni, Alessandra Salvetti, Elena Pompili, Valerio De Franchis, Stefano Puglisi-Allegra, Alessandro Frati, Michela Ferrucci, Francesco Fornai   +11 more
doaj   +1 more source

Prion protein PrPc interacts with molecular chaperones of the Hsp60 family [PDF]

Journal of Virology, 1996
Prions mediate the pathogenesis of certain neurodegenerative diseases, including bovine spongiform encephalopathy in cattle and Creutzfeldt-Jakob disease in humans. The prion particle consists mainly, if not entirely, of PrPSc, a posttranslationally modified isoform of the cellular host-encoded prion protein (PrPc).
F, Edenhofer, R, Rieger, M, Famulok, W, Wendler, S, Weiss, E L, Winnacker   +5 more
openaire   +2 more sources

Cellular Prion Protein (PrPc): Putative Interacting Partners and Consequences of the Interaction [PDF]

International Journal of Molecular Sciences, 2020
Cellular prion protein (PrPc) is a small glycosylphosphatidylinositol (GPI) anchored protein most abundantly found in the outer leaflet of the plasma membrane (PM) in the central nervous system (CNS). PrPc misfolding causes neurodegenerative prion diseases in the CNS.
Hajar Miranzadeh Mahabadi, Changiz Taghibiglou   +1 more
openaire   +2 more sources

Short-term memory formation and long-term memory consolidation are enhanced by cellular prion association to stress-inducible protein 1

Neurobiology of Disease, 2007
Cellular prion protein (PrPC) is a cell surface glycoprotein that interacts with several ligands such as laminin, NCAM (Neural-Cell Adhesion Molecule) and the stress-inducible protein 1 (STI1).
Adriana S. Coitinho, Marilene H. Lopes, Glaucia N.M. Hajj, Janine I. Rossato, Adriana R. Freitas, Cibele C. Castro, Martin Cammarota, Ricardo R. Brentani, Ivan Izquierdo, Vilma R. Martins   +9 more
doaj   +1 more source

HTLV-1 p12 modulates the levels of prion protein (PrPC) in CD4+ T cells

Frontiers in Microbiology, 2023
IntroductionInfection with human T cell lymphotropic virus type 1 (HTLV-1) is endemic in Brazil and is linked with pro-inflammatory conditions including HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP), a chronic neuroinflammatory ...
Isabela Silva De Castro, Isabela Silva De Castro, Alessandra Granato, Rafael Meyer Mariante, Rafael Meyer Mariante, Marco Antonio Lima, Ana Claudia Celestino Leite, Otávio de Melo Espindola, Cynthia A. Pise-Masison, Genoveffa Franchini, Rafael Linden, Juliana Echevarria-Lima   +11 more
doaj   +1 more source

Role of lipid rafts and GM1 in the segregation and processing of prion protein.

PLoS ONE, 2014
The prion protein (PrPC) is highly expressed within the nervous system. Similar to other GPI-anchored proteins, PrPC is found in lipid rafts, membrane domains enriched in cholesterol and sphingolipids.
Laura Botto, Diana Cunati, Silvia Coco, Silvia Sesana, Alessandra Bulbarelli, Emiliano Biasini, Laura Colombo, Alessandro Negro, Roberto Chiesa, Massimo Masserini, Paola Palestini   +10 more
doaj   +1 more source

The Multifaceted Functions of Prion Protein (PrPC) in Cancer

Cancers, 2023
The cellular prion protein (PrPC) is a glycoprotein anchored to the cell surface by glycosylphosphatidylinositol (GPI). PrPC is expressed both in the brain and in peripheral tissues. Investigations on PrPC’s functions revealed its direct involvement in neurodegenerative and prion diseases, as well as in various physiological processes such as anti ...
Roland Abi Nahed, Hasan Safwan-Zaiter, Kevin Gemy, Camille Lyko, Mélanie Boudaud, Morgane Desseux, Christel Marquette, Tiphaine Barjat, Nadia Alfaidy, Mohamed Benharouga   +9 more
openaire   +4 more sources

Exploration of the main sites for the transformation of normal prion protein (PrPC) into pathogenic prion protein (PrPsc)

Journal of Veterinary Research, 2017
Introduction: The functions and mechanisms of prion proteins (PrPC) are currently unknown, but most experts believe that deformed or pathogenic prion proteins (PrPSc) originate from PrPC, and that there may be plural main sites for the conversion of ...
Liu Xi-Lin, Feng Xiao-Li, Wang Guang-Ming, Gong Bin-Bin, Ahmad Waqas, Liu Nan-Nan, Zhang Yuan-Yuan, Yang Li, Ren Hong-Lin, Cui Shu-Sen   +9 more
doaj   +1 more source

Immunohistochemical Expression of Prion Protein (PrPC) in the Human Forebrain During Development [PDF]

Journal of Neuropathology and Experimental Neurology, 2006
The cellular prion protein (PrPC) is a ubiquitous protein whose expression in the adult brain occurs mainly in synapses. We used monoclonal antibodies to study fetal and perinatal PrPC expression in the human forebrain. Double immunofluorescence and confocal microscopy with GFAP, Iba1, MAP2, doublecortin, synaptophysin, and GAP-43 were used to localize
Adle-Biassette, Homa, Verney, Catherine, Peoc'h, Katell, Dauge, Marie-Christine, Razavi, Férechté, Choudat, Laurence, Gressens, Pierre, Budka, Herbert, Henin, Dominique   +8 more
openaire   +3 more sources