Results 51 to 60 of about 6,958 (184)

The Effects of Ca2+ Concentration and E200K Mutation on the Aggregation Propensity of PrPC: A Computational Study. [PDF]

PLoS ONE, 2016
The propensity of cellular prion protein to aggregation is reputed essential for the initiation of the amyloid cascade that ultimately lead to the accumulation of neurotoxic aggregates.
Alessandro Marrone, Nazzareno Re, Loriano Storchi   +2 more
doaj   +1 more source

SKALE: An Interpretable Multiscale Machine Learning Model for Decoding Phase‐Specific Protein Aggregation in Neurodegenerative Proteinopathies

Aggregate, Volume 7, Issue 2, February 2026.
Protein aggregation drives diverse degenerative diseases, yet its molecular origins are difficult to predict. SKALE uses interpretable machine learning to link sequence, structure, and dynamics, revealing how local structural weakening triggers aggregation.
Wei Xuan Wilson Loo, Jia Shen Sio, Keyin Yap, Yan Shan Loo, Hui Xuan Lim, Shuangyue Zhang, Huitao Liu, Chen Seng Ng   +7 more
wiley   +1 more source

Cellular Prion Protein: From Physiology to Pathology

Viruses, 2012
The human cellular prion protein (PrPC) is a glycosylphosphatidylinositol (GPI) anchored membrane glycoprotein with two N-glycosylation sites at residues 181 and 197. This protein migrates in several bands by Western blot analysis (WB).
Yutaka Kikuchi, José B. Oliveira-Martins, Yoshiko Sugita-Konishi, Sei-ichi Yusa   +3 more
doaj   +1 more source

Regulation of focal adhesion formation and filopodia extension by the cellular prion protein (PrPC) [PDF]

FEBS Letters, 2008
While the prion protein (PrP) is clearly involved in neuropathology, its physiological roles remain elusive. Here, we demonstrate PrP functions in cell–substrate interaction in Drosophila S2, N2a and HeLa cells. PrP promotes cell spreading and/or filopodia formation when overexpressed, and lamellipodia when downregulated.
Schrock, Yvonne, Solis Padilla, Gonzalo, Stürmer, Claudia   +2 more
openaire   +3 more sources

N‐Truncated Superoxide Dismutase‐1 in Cerebrospinal Fluid Is Folded and Active

Journal of Neurochemistry, Volume 170, Issue 2, February 2026.
Superoxide dismutase 1 (SOD1) mutations cause amyotrophic lateral sclerosis (ALS) through mechanisms involving protein misfolding and aggregation. While C‐terminal truncations of SOD1 promote neurotoxicity, our study reveals that approximately one‐third of SOD1 in cerebrospinal fluid (CSF) is N‐terminally truncated—a striking observation given the ...
Laura Leykam, Karin M. E. Forsberg, Peter M. Andersen, Thomas Brännström, Sophia Weiner, John Rönnholm, Kaj Blennow, Henrik Zetterberg, Stefan L. Marklund, Johan Gobom, Per Zetterström   +10 more
wiley   +1 more source

Cellular prion protein and γ-synuclein overexpression in LS 174T colorectal cancer cell drives endothelial proliferation-to-differentiation switch [PDF]

PeerJ, 2018
Background Tumor-induced angiogenesis is an imperative event in pledging new vasculature for tumor metastasis. Since overexpression of neuronal proteins gamma-synuclein (γ-Syn) and cellular prion protein (PrPC) is always detected in advanced stages of ...
Sing-Hui Ong, Kai-Wey Goh, Cornelius Kwang-Lee Chieng, Yee-How Say   +3 more
doaj   +2 more sources

Peripheral Signatures of Multidimensional Pathology in Symptomatic and Asymptomatic Creutzfeldt–Jakob Disease

CNS Neuroscience &Therapeutics, Volume 32, Issue 1, January 2026.
Plasma biomarkers in CJD reveal multisystem involvement, with neuronal injury markers showing strong discriminative performance and vascular proteins indicating blood–brain barrier dysfunction. In asymptomatic PRNP mutation carriers, biomarker changes are minimal and emerge mainly near disease onset ABSTRACT Background Plasma markers of neuronal injury
Zhong‐Yun Chen, Min Chu, Yi‐Hao Wang, Rui Liu, Jing Zhang, Ai‐ling Yue, Hua Lu, Qian‐qian He, Jia‐hui Hou, Yu‐fei Chen, Hong Ye, Li‐Yong Wu   +11 more
wiley   +1 more source

EGFR and Prion protein promote signaling via FOXO3a‐KLF5 resulting in clinical resistance to platinum agents in colorectal cancer

Molecular Oncology, 2019
Epidermal growth factor receptor (EGFR) supports colorectal cancer progression via oncogenic signaling. Anti‐EGFR therapy is being investigated as a clinical option for colorectal cancer, and an observed interaction between EGFR and Prion protein has ...
Caroline J. Atkinson, Futoshi Kawamata, Cheng Liu, Sunyoung Ham, Balázs Győrffy, Alan L. Munn, Ming Q. Wei, Andreas Möller, Vicki Whitehall, Adrian P. Wiegmans   +9 more
doaj   +1 more source

Monomeric amyloid-β reduced amyloid-β oligomer-induced synapse damage in neuronal cultures

Neurobiology of Disease, 2018
Alzheimer's disease is a progressive neurodegenerative disease characterized by the accumulation of amyloid-β (Aβ) in the brain. Aβ oligomers are believed to cause synapse damage resulting in the memory deficits that are characteristic of this disease ...
Clive Bate, Alun Williams
doaj   +1 more source

Therapeutic Potential of Melatonin in Gastrointestinal Cancers: Molecular Mechanisms, Preclinical Evidence and Clinical Implications

Journal of Pineal Research, Volume 78, Issue 1, January 2026.
ABSTRACT Gastrointestinal (GI) cancers remain a leading cause of global morbidity and mortality, necessitating novel therapeutic strategies. Melatonin (MEL), an indoleamine with pleiotropic biological activities, has emerged as a promising adjuvant in oncology due to its antiproliferative, proapoptotic, and antioxidant properties.
Maciej Gonciarz, Benita Wiatrak, Iga Lombard, Łukasz Konecki, Joanna Sarbinowska   +4 more
wiley   +1 more source