Results 81 to 90 of about 5,869 (184)

Altered Ca2+ homeostasis induces Calpain-Cathepsin axis activation in sporadic Creutzfeldt-Jakob disease

Acta Neuropathologica Communications, 2017
Sporadic Creutzfeldt-Jakob disease (sCJD) is the most prevalent form of human prion disease and it is characterized by the presence of neuronal loss, spongiform degeneration, chronic inflammation and the accumulation of misfolded and pathogenic prion ...
Franc Llorens, Katrin Thüne, Beata Sikorska, Matthias Schmitz, Waqas Tahir, Natalia Fernández-Borges, Maria Cramm, Nadine Gotzmann, Margarita Carmona, Nathalie Streichenberger, Uwe Michel, Saima Zafar, Anna-Lena Schuetz, Ashish Rajput, Olivier Andréoletti, Stefan Bonn, Andre Fischer, Pawel P. Liberski, Juan Maria Torres, Isidre Ferrer, Inga Zerr   +20 more
doaj   +1 more source

Femtogram Electrochemical Sensing of Prion Proteins Using Quantum Dots

International Journal of Electrochemical Science, 2013
The prion protein (PrP) is involved in neurodegeneration via its conversion from the normal cellular form, PrPC, to the infectious form, PrPSc, which is the causative agent of the transmissible spongiform encephalopathies (TSEs) including Creutzfeldt ...
Pavlina Sobrova, Marketa Ryvolova, Vladimir Pekarik, Jaromir Hubalek, Vojtech Adam, Rene Kizek   +5 more
doaj   +1 more source

A comparative analysis between PrPc and PrPsc to determine the structure‐function relationship of protein misfolding in Scrapie prion disease

The FASEB Journal, 2019
The Minnetonka MSOE Center for BioMolecular Modeling SMART Team used 3D modeling and printing technology to examine structure‐function relationships of PrPsc. Scrapies is caused by prions, misfolded proteins in animals and humans, resulting in the development of fatal neurodegenerative encephalitis.
Alison Peterson, Catherine Borisova, Priscilla Bunday, Meili Gong, Daniela Hernandez Merlin, Nicholas Kachkovsky, Eli Quist, Ming Ying Yeoh   +7 more
openaire   +1 more source

Prominent Stress Response of Purkinje Cells in Creutzfeldt–Jakob Disease

Neurobiology of Disease, 2001
To examine the role of stress-related 70-kDa heat shock proteins (Hsp-s) in Creutzfeldt–Jakob disease (CJD), we performed immunocytochemistry to detect Hsp-72 and Hsp-73, together with the abnormal (PrPSc) and the presumed cellular form (PrPC) of the ...
Gábor G. Kovács, István Kurucz, Herbert Budka, Csaba Ádori, Ferenc Müller, Péter Ács, Stefan Klöppel, Hermann M. Schätzl, R.John Mayer, Lajos László   +9 more
doaj   +1 more source

Magnetic microparticle-based multimer detection system for the detection of prion oligomers in sheep

International Journal of Nanomedicine, 2015
Kuntaek Lim,1 Su Yeon Kim,2 Byoungsub Lee,1 Christiane Segarra,3 Sungmin Kang,1 Youngran Ju,2 Mary Jo Schmerr,4 Joliette Coste,3 Sang Yun Kim,5 Takashi Yokoyama,6 Seong Soo A An7 1Department of Research and Development, PeopleBio Inc., 2Department of ...
Lim K, Kim SY, Lee B, Segarra C, Kang S, Ju YR, Schmerr MJ, Coste J, Kim SY, Yokoyama T, An SSA   +10 more
doaj  

Molecular signatures in prion disease: altered death receptor pathways in a mouse model

Journal of Translational Medicine
Background Prion diseases are transmissible and fatal neurodegenerative diseases characterized by accumulation of misfolded prion protein isoform (PrPSc), astrocytosis, microgliosis, spongiosis, and neurodegeneration.
Ranjit Kumar Giri
doaj   +1 more source

Decontamination of surgical instruments from prion proteins: in vitro studies on the detachment, destabilization and degradation of PrPSc bound to steel surfaces

Journal of General Virology, 2004
Effective reprocessing of surgical instruments ensuring elimination of inadvertent contamination with infectious agents causing transmissible spongiform encephalopathies (TSEs) is essential for the prevention of iatrogenic transmission of Creutzfeldt-Jakob disease (CJD) or its new variant (vCJD) from asymptomatic carriers. In a search for effective yet
Karin, Lemmer, Martin, Mielke, Georg, Pauli, Michael, Beekes   +3 more
openaire   +2 more sources

RESEARCH AND DEVELOPMENT CONTROL METHOD PATHOGENIC PRION INFECTIONS SECONDARY RAW MEAT INDUSTRY

Теория и практика переработки мяса, 2016
Highly sensitive and specific method for identification of pathogenic prion protein was developed. It was found that the water-soluble fractions of beef proteins and plasma proteins of farm animals are normal prion proteins in cattle.
A. Y. Prosekov, O. V. Kriger
doaj   +1 more source

Investigating the relationship between abnormal prion protein (PrPSc) and the transmissible spongiform encephalopathy (TSE) infectious agent

, 2013
Transmissible spongiform encephalopathies (TSEs) are a group of fatal, neurodegenerative diseases that can affect both humans and animals. TSEs can be sporadic, familial, or acquired diseases. The prion hypothesis states that a misfolded form of the host glycoprotein, PrPC, acts as the infectious agent in TSE disease.
openaire   +2 more sources

Accumulation of Pathological Prion Protein PrPSc in the Skin of Animals with Experimental and Natural Scrapie

PLoS Pathogens, 2007
Prion infectivity and its molecular marker, the pathological prion protein PrP(Sc), accumulate in the central nervous system and often also in lymphoid tissue of animals or humans affected by transmissible spongiform encephalopathies. Recently, PrP(Sc) was found in tissues previously considered not to be invaded by prions (e.g., skeletal muscles). Here,
Thomzig, Achim, Schulz-Schaeffer, Walter, Wrede, Arne, Wemheuer, Wilhelm, Brenig, Bertram, Kratzel, Christine, Lemmer, Karin, Beekes, Michael   +7 more
openaire   +6 more sources