Results 191 to 200 of about 1,026,176 (295)

Microbiome—pancreatic cancer crosstalk: From tumor biology to therapeutic intervention

iMetaOmics, EarlyView.
The intratumoral microbiome acts as a critical regulator in pancreatic cancer progression and therapeutic resistance. This comprehensive review delineates the origins of pancreatic microbes, elucidates their multifaceted mechanisms in driving immune suppression, metabolic reprogramming, and stromal desmoplasia, and highlights the clinical potential of ...
Yuqin Xie, Jingyuan Ye, Sheng Wang, Maoyun Liu, Fengsheng Dai, Mingzhen Bai, Yi Wang, Athena Savoji, Yu Wang, Phillip B. Hylemon, Huiping Zhou, Hui Li, Dewei Li   +12 more
wiley   +1 more source

Artificial intelligence driven diet‐intestinal microbiota‐host health integration: A four‐dimensional paradigm for advancing host wellness research

iMetaOmics, EarlyView.
This graphical abstract presents a novel Diet‐Artificial Intelligence (AI)‐intestinal Microbiota–Host Health paradigm integrating microbiota‐centric pathways and an AI‐driven multi‐omics workflow. Diet shapes gut bacteria that regulate intestinal mucosal integrity, immune signaling, and gut–brain neurotransmitters to influence host health.
Tianle He, Shuobo Zhang, Jiaxin Chen, Xiaoling Zheng, Jixin Zhao, Huifeng Li, Jiani Mao, Ju Luo, Jundan Zheng, Dengjun Ma, Lihong Wang, Junhui Liu, Wen Tian, Shuangming Yang, Chengli Liu, Ke Tian, Zhenguo Yang   +16 more
wiley   +1 more source

Bacterial indole‐3‐butyric acid promotes fish PUFA synthesis

iMetaOmics, EarlyView.
Polyunsaturated fatty acids (PUFAs) are essential nutrients in aquatic products, yet the contribution of gut microbiota‐derived metabolites to PUFA biosynthesis remains largely unknown. In this study, a gut‐derived Bacillus strain was identified to enhance PUFA accumulation via indole‐3‐butyric acid (IBA) production.
Ruojing Li, Biao Yuan, Xin Yi, Jieyan Lin, Bi Huang, Ermei Yin, Jiayu Zhou, Qianwen Min, Meiqi Lv, Bo Zhang, Na Zhao   +10 more
wiley   +1 more source

Macrophage extracellular vesicles deliver Mef2d proteins to aggravate Bacteroides fragilis pathogenicity in type 2 diabetes arterial calcification

Interdisciplinary Medicine, EarlyView.
Bacteroides fragilis is associated with type 2 diabetes (T2D) arterial calcification and can be activated by macrophage‐derived extracellular vesicles (EVs). BF takes up EVs via receptor‐mediated endocytosis, and activation is induced by EV‐derived Mef2d, thereby inhibiting ArsR family transcriptional regulator transcription.
Cong Chen, Rong He, Jirong Luo, Zhengfeng Liang, Qunwen Pan, Shuangquan Liu, Jingsong Cao   +6 more
wiley   +1 more source

Metrnβ drives sepsis immunosuppression via macrophage reprogramming: A novel prognostic biomarker and therapeutic target

Interdisciplinary Medicine, EarlyView.
Metrnβ serves as a novel prognostic biomarker for sepsis and that targeted blockade of the Metrnβ‐c‐Kit axis represents a promising therapeutic strategy for sepsis. Abstract Sepsis is a heterogeneous syndrome critically driven by immunosuppression, yet lacking personalized prognostic markers and therapeutic targets. Here, we provide evidence to support
Xiao Li, Ai Chen, Chen Zhang, Meihong Da, Yonghui Liu, Zhi He, Chenyan Yuan, Shuo Ma, Yuming Yao, Dawen Chen, Meiling Zhou, Zhixin Song, Wenjing Lu, Chun‐Kwok Wong, Guoqiu Wu, Xun Gao   +15 more
wiley   +1 more source

Targeting the intratumoral microbiota to overcome cancer immunotherapy resistance

Interdisciplinary Medicine, EarlyView.
This review delineates the mechanisms of intratumoral microbiota in cancer immunotherapy resistance, and offers strategies for microbiota‐targeted precision immunotherapy. Abstract Cancer remains a significant global health threat. The tumor microenvironment (TME) is a sophisticated ecological niche that exerts a pivotal effect on treatment outcomes ...
Bufu Tang, Tong Jiang, Yaling Lin, Wei Zhang, Hongjie Fan, Minjie Yang, Bingzhe Li, Yaozu Liu, Changyu Li, Xuran Jin, Wen Zhang, Zhiping Yan, Qianqian Zhao, Xuefeng Kan, Xudong Qu   +14 more
wiley   +1 more source

Organ‐Specific Human Microbiomes and Dysbiosis: Mechanistic Links to Disease and Emerging Therapeutic Strategies

Journal of Clinical Laboratory Analysis, EarlyView.
Schematic overview of the human microbiome and major microbiota‐derived metabolites across body sites, highlighting the gut–brain, gut–heart, and gut–kidney axes in host physiology and disease. ABSTRACT Background The human microbiome is a dynamic and diverse community of microorganisms that affects susceptibility to illness and promotes wellness ...
Awadh Alanazi
wiley   +1 more source

Factors associated with discharge on higher respiratory support for children with tracheostomy hospitalized with bacterial tracheostomy‐associated infections: A prospective, multicenter cohort study

Journal of Hospital Medicine, EarlyView.
Abstract We conducted a multicenter prospective cohort study to identify factors associated with discharge on higher respiratory support in children with tracheostomy hospitalized for bacterial tracheostomy‐associated infections (bTRAINs). We included children 0–21 years with tracheostomy hospitalized for bTRAIN at six freestanding children's hospitals
Krystal S. Jin, Naoko Kono, Jonathan D. Cogen, Sarah Hofman DeYoung, Catherine S. Forster, Andrea Hahn, Margaret Rush, John M. Morrison, Joanna E. Thomson, Sukhada V. Mairal, Michael N. Neely, Wendy J. Mack, Tamara D. Simon, Christopher J. Russell   +13 more
wiley   +1 more source

Robust Spectroscopic Analysis Through Image‐Based Spectral Representation and Deep Learning Techniques

Journal of Raman Spectroscopy, EarlyView.
This study addresses calibration drift in Raman spectroscopy by transforming 1D spectra into 2D spider plot images processed by pretrained convolutional neural networks. This visualization strategy effectively converts detrimental spectral wavenumber shifts into simple image rotations, allowing the deep learning model to maintain high classification ...
Azadeh Mokari, Oleg Ryabchykov, Thomas Bocklitz   +2 more
wiley   +1 more source

Microbial communities and functional diversity in seafood

JSFA reports, EarlyView.
Abstract Functional diversity encompasses ecosystem processes that enhance adaptability to environmental change. This study explores the diversity of microorganisms associated with seafood. In this paper, we present our knowledge of microbial diversity in relation to seafood.
Christian Larbi Ayisi, Samuel Ayeh Osei, Grace Afumwaa Boamah, Gertrude Dzifa Mensah   +3 more
wiley   +1 more source