Results 11 to 20 of about 8,243 (225)

Pseudorabies virus (PRV) strain with defects in gE, gC, and TK genes protects piglets against an emerging PRV variant. [PDF]

J Vet Med Sci, 2020
The prevalence of an emerging variant of the pseudorabies virus (PRV) has been causing serious losses to farmers in China. Moreover, the commercially available PRV vaccine often fails to provide thorough protection. Therefore, in this study, we generated a PRV-∆gC\gE∆TK strain with defects in gC, gE, and TK of PRV.
Lin J, Li Z, Feng Z, Fang Z, Chen J, Chen W, Liang W, Chen Q.   +7 more
europepmc   +4 more sources

Implication of the Identification of an Earlier Pseudorabies Virus (PRV) Strain HLJ-2013 to the Evolution of Chinese PRVs. [PDF]

Front Microbiol, 2020
Pseudorabies viruses (PRVs) pose a great threat to the pig industry of many countries around the world. Human infections with PRV have also been reported occasionally in China. Therefore, understanding the epidemiology and evolution of PRVs is of great importance for disease control in the pig populations and humans as well.
Liu H, Shi Z, Liu C, Wang P, Wang M, Wang S, Liu Z, Wei L, Sun Z, He X, Wang J.   +10 more
europepmc   +5 more sources

Generation of Premature Termination Codon (PTC)-Harboring Pseudorabies Virus (PRV) via Genetic Code Expansion Technology. [PDF]

Viruses, 2022
Despite many efforts and diverse approaches, developing an effective herpesvirus vaccine remains a great challenge. Traditional inactivated and live-attenuated vaccines always raise efficacy or safety concerns. This study used Pseudorabies virus (PRV), a swine herpes virus, as a model.
Wang TY, Sang GJ, Wang Q, Leng CL, Tian ZJ, Peng JM, Wang SJ, Sun MX, Meng FD, Zheng H, Cai XH, Tang YD.   +11 more
europepmc   +4 more sources

Rosmarinic Acid inhibits Pseudorabies Virus (PRV) infection by activating the cGAS-STING signaling pathway. [PDF]

BMC Microbiol
Pseudorabies virus (PRV), a swine alphaherpesvirus, is a double-stranded DNA virus. It may infect various animals, especially pigs. PRV infection in pigs leads to high mortality rates, and causes huge economic lose for swine industry. Currently, there are few effective antiviral treatments available.
Hu T, Gao S, Yu Z, Liu Y, Tang H, Xu Z, Zhu L, Zhao L, Ye G, Shi F.   +9 more
europepmc   +4 more sources

Functional analysis of prv-miR-LLT11a encoded by pseudorabies virus [PDF]

Journal of Veterinary Science, 2019
Viral-encoded microRNAs (miRNAs) have vital roles in the regulation of virus replications and host immune responses. The results of previous studies have indicated that miRNA clusters are involved in the replication and virulence of the pseudorabies virus (PRV), which may potentially lead to immune escape or facilitation of PRV replication.
Huimin Liu, Li Yang, Zhibin Shi, Ruiqi Lv, Xia Yang, Chuanqing Wang, Lu Chen, Hongtao Chang   +7 more
openaire   +2 more sources

Multimodal Imaging Reveals Cerebral Microcirculation Dynamics and Mechanisms in Mouse Central Nervous System After Intranasal Infection With Recombinant Pseudorabies Virus. [PDF]

Adv Sci (Weinh)
Multi‐modality imaging strategy applied to PRV‐induced central nervous system infection enables dynamic visualization of cerebrovascular dysfunction, including hyperemia, hypoperfusion, and vascular remodeling. These changes are linked to microglial activation and impaired angiogenesis, providing mechanistic insight into PRV neuropathogenesis and ...
Ling S, Wu C, Gui M, Chen K, Yang Y, Xing J, Du F, Liao W, Yang L, Jin Z, Xia N, Wang G, Chen Y, Zhao Q.   +13 more
europepmc   +2 more sources

Recombinant pseudorabies virus with gI/gE deletion generated by overlapping polymerase chain reaction and homologous recombination technology induces protection against the PRV variant PRV-GD2013

BMC Veterinary Research, 2021
Background Since 2011, numerous highly virulent and antigenic variant viral strains have been reported in pigs that were vaccinated against the swine pseudorabies virus.
Wenhui Li, Dijing Zhuang, Hong Li, Mengpo Zhao, Erpeng Zhu, Baoming Xie, Jinding Chen, Mingqiu Zhao   +7 more
doaj   +1 more source

CRISPR/Cas9-based generation of a recombinant double-reporter pseudorabies virus and its characterization in vitro and in vivo

Veterinary Research, 2021
Pseudorabies, caused by pseudorabies virus (PRV) variants, has broken out among commercial PRV vaccine-immunized swine herds and resulted in major economic losses to the pig industry in China since late 2011.
Peng-Fei Fu, Xuan Cheng, Bing-Qian Su, Li-Fang Duan, Cong-Rong Wang, Xin-Rui Niu, Jiang Wang, Guo-Yu Yang, Bei-Bei Chu   +8 more
doaj   +1 more source

Pseudorabies gD protein protects mice and piglets against lethal doses of pseudorabies virus

Frontiers in Microbiology, 2023
IntroductionPseudorabies (PR) is a highly contagious viral disease caused by the pseudorabies virus (PRV), which can cause disease in a wide range of domestic and wild animals.
Mengpo Zhao, Mengpo Zhao, Jing Chen, Shengjun Luo, Renhe Yan, Pian Zhang, Zhaowen Ren, Zhaowen Ren, Xiaofan Chen, Xiaofan Chen, Gang Wang, Hua Xiang, Rujian Cai, Yuan Huang, Na Li, Na Li, Hongwei Li, Zi-Guo Yuan, Xiaohu Wang   +18 more
doaj   +1 more source

Vaccine resistant pseudorabies virus causes mink infection in China

BMC Veterinary Research, 2018
Background Pseudorabies, a highly contagious infectious disease of swine is caused by pseudorabies virus (PRV). PRV can cause fatal infection in other animal species. Results We report a deadly outbreak of pseudorabies that killed 87.2% (3522/4028) minks
Gui-sheng Wang, Yijun Du, Jia-qiang Wu, Fu-lin Tian, Xue-jie Yu, Jin-bao Wang   +5 more
doaj   +1 more source