Results 31 to 40 of about 8,213 (212)

A gD&gC-substituted pseudorabies virus vaccine strain provides complete clinical protection and is helpful to prevent virus shedding against challenge by a Chinese pseudorabies variant

BMC Veterinary Research, 2019
Background Since 2011, pseudorabies caused by a variant PRV has re-emerged in many Chinese Bartha-K61-vaccinated pig farms. An efficacious vaccine is necessary to control this disease.
Chuanjian Zhang, Yamei Liu, Saisai Chen, Yongfeng Qiao, Mingpeng Guo, Yating Zheng, Mengwei Xu, Zhisheng Wang, Jibo Hou, Jichun Wang   +9 more
doaj   +1 more source

Design of live-attenuated animal vaccines based on pseudorabies virus platform

Animal Diseases, 2022
Pseudorabies virus (PRV) is a double-stranded DNA virus with a genome approximating 150 kb in size. PRV contains many non-essential genes that can be replaced with genes encoding heterogenous antigens without affecting viral propagation. With the ability
Zhen Liu, Zhengjie Kong, Meng Chen, Yingli Shang   +3 more
doaj   +1 more source

Pseudorabies virus (PRV)-specific antibodies suppress intracellular viral protein levels in PRV-infected monocytes

Journal of General Virology, 2003
Blood monocytes infected with pseudorabies virus (PRV), a swine alphaherpesvirus, are not eliminated efficiently by antibody-dependent immunity and may occasionally transport PRV to the pregnant uterus of vaccinated animals. This study examines in vitro the long-term fate of PRV-infected monocytes cultivated in the presence of porcine PRV-specific ...
Herman W, Favoreel, Gerlinde R, Van de Walle, Hans J, Nauwynck, Thomas C, Mettenleiter, Maurice B, Pensaert   +4 more
openaire   +2 more sources

Host-virus interactions in PK-15 cells infected with Pseudorabies virus Becker strain based on RNA-seq

Virus Research, 2022
Pseudorabies is a highly contagious viral disease caused by the pseudorabies virus (PRV), and it is one of the most devastating diseases for the swine industry worldwide.
Aishao Shangguan, Jingjin Li, Yumei Sun, Zhongzhu Liu, Shujun Zhang   +4 more
doaj   +1 more source

Mechanism of Pruritus and Peracute Death in Mice Induced by Pseudorabies Virus(PRV) Infection.

Journal of Veterinary Medical Science, 1993
Mechanisms of postinfectious pruritus and peracute death in mice by pseudorabies virus (PRV) were investigated by inoculating the Yamagata-S81 strain of PRV peripherally or intracerebrally into 4-week-old ICR and BALB/c mice. Clinical signs developed most rapidly in mice inoculated intracerebrally, with intermediate speed in mice inoculated ...
H, Takahashi, Y, Yoshikawa, C, Kai, K, Yamanouchi   +3 more
openaire   +3 more sources

A novel recombinant pseudorabies virus expressing parvovirus VP2 gene: Immunogenicity and protective efficacy in swine

Virology Journal, 2011
Background Porcine parvovirus (PPV) VP2 gene has been successfully expressed in many expression systems resulting in self-assembly of virus-like particles (VLPs) with similar morphology to the native capsid.
Chen Dishi, Shi Qian, Luo Yan, Yan Qigui, Xu Zhiwen, Guo Wanzhu, Chen Yang, Zhu Ling, Wang Xiaoyu   +8 more
doaj   +1 more source

Varicellovirus UL 49.5 proteins differentially affect the function of the transporter associated with antigen processing, TAP [PDF]

, 2008
Cytotoxic T-lymphocytes play an important role in the protection against viral infections, which they detect through the recognition of virus-derived peptides, presented in the context of MHC class I molecules at the surface of the infected cell.
Bienkowska-Szewczyk, Krystyna, Chowdhury, Shafiqul I., Daus, Franz, Heemskerk, Mirjam H. M., Koch, Joachim, Koppers-Lalic, Danijela, Lipinska, Andrea D., Loch, Sandra, Marcondes Rezende, Marisa, Mettenleiter, Thomas C., Neefjes, Jacques J., Osterrieder, Nikolaus, Quinten, Edwin, Reits, Eric A., Ressing, Maaike E., Rijsewijk, Frans A. M., Tampé, Robert, Verweij, Marieke C., Wang, Ying, Wiertz, Emmanuel J. H. J.   +19 more
core   +4 more sources

Ex vivo infection of human embryonic spinal cord neurons prior to transplantation into adult mouse cord [PDF]

, 2010
Background Genetically modified pseudorabies virus (Prv) proved suitable for the delivery of foreign genes to rodent embryonic neurons ex vivo and maintaining foreign gene expression after transplantation into spinal cord in our earlier study.
Gábor Márton, Dóra Tombácz, Judit S Tóth, András Szabó, Zsolt Boldogköi, Ádám Dénes, Ákos Hornyák, Antal Nógrádi   +7 more
core   +2 more sources

Tegument Assembly and Secondary Envelopment of Alphaherpesviruses. [PDF]

, 2015
Alphaherpesviruses like herpes simplex virus are large DNA viruses characterized by their ability to establish lifelong latent infection in neurons. As for all herpesviruses, alphaherpesvirus virions contain a protein-rich layer called "tegument" that ...
Crump, Colin M, Graham, Stephen C, Owen, Danielle J   +2 more
core   +6 more sources

Comprehensive evaluation of the safety and immunogenicity of a gene-deleted variant pseudorabies virus attenuated vaccine

Veterinary Research, 2022
Pseudorabies virus (PRV) variant infections have caused a substantial economic impact on swine production in the absence of new powerful candidate vaccines.
Ling Li, Yongfeng Du, Yanbin Zhang, Pengyu Li, Xinyue Liu, Xin Zhang, Jing Li, Tong Zhang, Xin Li, Dong Xiao, Peng Liu, Peng Qi, Jin Xiao   +12 more
doaj   +1 more source