Results 11 to 20 of about 8,213 (212)

Persistent Circulation of Pseudorabies Virus Variants in China: Genomic Features, Pathogenic Characteristics, and Cross-Protective Efficacy of Variant Strain Vaccines. [PDF]

Transbound Emerg Dis
The continuous circulation of pseudorabies virus (PRV) variants persists in causing substantial economic losses within China’s swine industry. Nevertheless, the molecular characteristics and pathogenic potential of the recently emerged variants remain poorly understood, and the cross‐protective effectiveness of the newly developed vaccines based on ...
Guo Z, Kang H, Feng Z, Zhang X, Shi J, Li J, Song Z, Xiang L, Gong B, Xu H, Leng C, Zhou G, Wang Q, Tang Y, An T, Cai X, Tian Z, Peng J, Zhang H.   +18 more
europepmc   +2 more sources

Rosmarinic Acid inhibits Pseudorabies Virus (PRV) infection by activating the cGAS-STING signaling pathway. [PDF]

BMC Microbiol
Pseudorabies virus (PRV), a swine alphaherpesvirus, is a double-stranded DNA virus. It may infect various animals, especially pigs. PRV infection in pigs leads to high mortality rates, and causes huge economic lose for swine industry. Currently, there are few effective antiviral treatments available.
Hu T, Gao S, Yu Z, Liu Y, Tang H, Xu Z, Zhu L, Zhao L, Ye G, Shi F.   +9 more
europepmc   +4 more sources

Genome editing of pseudorabies virus in the CRISPR/Cas9 era: a mini-review

Frontiers in Veterinary Science, 2023
Pseudorabies virus (PRV) is an important swine virus that has a significant impact on the global swine industry. PRV is a member of the herpesvirus family, specifically the alphaherpesvirus subfamily, and has been extensively utilized as a prototype ...
Hai-Ming Wang, Yang-Yang Qiao, Bing-Yan Cai, Ju Tan, Lei Na, Lei Na, Yu Wang, Hui Lu, Yan-Dong Tang, Yan-Dong Tang   +9 more
doaj   +1 more source

Functional analysis of prv-miR-LLT11a encoded by pseudorabies virus [PDF]

Journal of Veterinary Science, 2019
Viral-encoded microRNAs (miRNAs) have vital roles in the regulation of virus replications and host immune responses. The results of previous studies have indicated that miRNA clusters are involved in the replication and virulence of the pseudorabies virus (PRV), which may potentially lead to immune escape or facilitation of PRV replication.
Huimin Liu, Li Yang, Zhibin Shi, Ruiqi Lv, Xia Yang, Chuanqing Wang, Lu Chen, Hongtao Chang   +7 more
openaire   +2 more sources

Cross species transmission of pseudorabies virus leads to human encephalitis and visual impairment: A case report

Frontiers in Neurology, 2022
Pseudorabies virus (PRV) is a common pig infectious disease. There have been few reports of PRV infection in humans. The patient in this article had acute onset, which was manifested by fever, epilepsy, disturbance of consciousness, and other symptoms ...
Hui Huang, Na Wang, Zhi-Bing Ai, Jun Chen, Wei Huang, Yi Bao   +5 more
doaj   +1 more source

A case report of long-delayed diagnosis of pseudorabies virus encephalitis with endophthalmitis: lessons from metagenomic next generation sequencing

BMC Neurology, 2023
Background Pseudorabies virus (PRV) was thought to only infect animals. Recent studies have shown that it can also infect human. Case presentation We report a case of pseudorabies virus encephalitis and endophthalmitis, diagnosed 89 days after onset ...
Yi Zhang, Lei Fang, Yi Zhou, Yongqing Zhang, Bing Liang, Chuanzhu Yan, Ling Li   +6 more
doaj   +1 more source

Identification of Inputs to Olivocochlear Neurons Using Transneuronal Labeling with Pseudorabies Virus (PRV) [PDF]

Journal of the Association for Research in Otolaryngology, 2013
Olivocochlear (OC) neurons respond to sound and provide descending input that controls processing in the cochlea. The identities of neurons in the pathways providing inputs to OC neurons are incompletely understood. To explore these pathways, the retrograde transneuronal tracer pseudorabies virus (Bartha strain, expressing green fluorescent protein ...
M Christian, Brown, Sudeep, Mukerji, Marie, Drottar, Alanna M, Windsor, Daniel J, Lee   +4 more
openaire   +2 more sources

Recombinant pseudorabies virus with gI/gE deletion generated by overlapping polymerase chain reaction and homologous recombination technology induces protection against the PRV variant PRV-GD2013

BMC Veterinary Research, 2021
Background Since 2011, numerous highly virulent and antigenic variant viral strains have been reported in pigs that were vaccinated against the swine pseudorabies virus.
Wenhui Li, Dijing Zhuang, Hong Li, Mengpo Zhao, Erpeng Zhu, Baoming Xie, Jinding Chen, Mingqiu Zhao   +7 more
doaj   +1 more source

CRISPR/Cas9-based generation of a recombinant double-reporter pseudorabies virus and its characterization in vitro and in vivo

Veterinary Research, 2021
Pseudorabies, caused by pseudorabies virus (PRV) variants, has broken out among commercial PRV vaccine-immunized swine herds and resulted in major economic losses to the pig industry in China since late 2011.
Peng-Fei Fu, Xuan Cheng, Bing-Qian Su, Li-Fang Duan, Cong-Rong Wang, Xin-Rui Niu, Jiang Wang, Guo-Yu Yang, Bei-Bei Chu   +8 more
doaj   +1 more source

Vaccine resistant pseudorabies virus causes mink infection in China

BMC Veterinary Research, 2018
Background Pseudorabies, a highly contagious infectious disease of swine is caused by pseudorabies virus (PRV). PRV can cause fatal infection in other animal species. Results We report a deadly outbreak of pseudorabies that killed 87.2% (3522/4028) minks
Gui-sheng Wang, Yijun Du, Jia-qiang Wu, Fu-lin Tian, Xue-jie Yu, Jin-bao Wang   +5 more
doaj   +1 more source