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Transcriptome-wide dynamics of RNA pseudouridylation [PDF]
Nature Reviews Molecular Cell Biology, 2015 Pseudouridylation is the most abundant internal post-transcriptional modification of stable RNAs, with fundamental roles in the biogenesis and function of spliceosomal small nuclear RNAs (snRNAs) and ribosomal RNAs (rRNAs). Recently, the first transcriptome-wide maps of RNA pseudouridylation were published, greatly expanding the catalogue of known ...
John Joseph Karijolich +2 more
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Posttranscriptional RNA Pseudouridylation [PDF]
The Enzymes, 2017 Pseudouridine (Ψ) is the most abundant posttranscriptional modification in noncoding RNAs. Pseudouridines are often clustered in important regions of rRNAs (ribosomal RNAs), snRNAs (small nuclear RNAs), and tRNAs (transfer RNAs), contributing to RNA function. Pseudouridylation is governed by two independent mechanisms. The first involves single protein
Yi-Tao Yu, Meemanage D de Zoysa
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Characterizing RNA Pseudouridylation by Convolutional Neural Networks
Genomics, Proteomics and Bioinformatics, 2021 Abstract Pseudouridine (Ψ) is the most prevalent post-transcriptional RNA modification and is widespread in small cellular RNAs and mRNAs. However, the functions, mechanisms, and precise distribution of Ψs (especially in mRNAs) still remain largely unclear. The landscape of Ψs across the transcriptome has not yet been fully delineated.
Sai Zhang, Yanqing Zhang, Tao Jiang
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The importance of pseudouridylation: human disorders related to the fifth nucleoside
Biologia Futura, 2023 AbstractPseudouridylation is one of the most abundant RNA modifications in eukaryotes, making pseudouridine known as the “fifth nucleoside.” This highly conserved alteration affects all non-coding and coding RNA types. Its role and importance have been increasingly widely researched, especially considering that its absence or damage leads to serious ...
Magdolna Keszthelyi, Kálmán Tory
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Relevance of 2′-O-Methylation and Pseudouridylation for the Malignant Melanoma [PDF]
Cancers, 2021 The two RNA modifications 2′-O-methylation and pseudouridylation occur on several RNA species including ribosomal RNAs leading to an increased translation as well as cell proliferation associated with distinct functions. Using malignant melanoma (MM) as a model system the proteins mediating these RNA modifications were for the first time analyzed by ...
Simon Jasinski-Bergner +2 more
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2021
Pseudouridine profiling has revealed many previously unknown sites of the RNA modification pseudouridine (Ψ) in cellular RNAs. All organisms express multiple pseudouridine synthases (PUS) whose RNA targets and mechanisms of targeting remain to be elucidated.
Nicole M, Martinez, Wendy V, Gilbert
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Pseudouridine profiling has revealed many previously unknown sites of the RNA modification pseudouridine (Ψ) in cellular RNAs. All organisms express multiple pseudouridine synthases (PUS) whose RNA targets and mechanisms of targeting remain to be elucidated.
Nicole M, Martinez, Wendy V, Gilbert
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Functions and therapeutic applications of pseudouridylation
Nature Reviews Molecular Cell BiologyThe success of using pseudouridine (Ψ) and its methylation derivative in mRNA vaccines against SARS-CoV-2 has sparked a renewed interest in this RNA modification, known as the 'fifth nucleotide' of RNA. In this Review, we discuss the emerging functions of pseudouridylation in gene regulation, focusing on how pseudouridine in mRNA, tRNA and ribosomal ...
Chengqi Yi, Meiling Zhang, Nan Luo
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Mechanisms and Clinical Applications of RNA Pseudouridylation
RNA Technologies, 2021Pseudouridylation is perhaps the most common epitranscriptomic modification among over 170 known chemical RNA modifications. Pseudouridine (Ψ) is highly conserved in various stable RNAs of all organisms. RNA pseudouridylation can be catalyzed by an RNA-independent mechanism by which stand-alone enzymes, known as pseudouridine synthases, recognize the ...
Pedro Morais, Yi-Tao Yu, Hironori Adachi
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Glioblastoma Is Dependent on tRNA Pseudouridylation
Cancer Discovery, 2021Abstract The pseudouridine synthase PUS7 is upregulated in glioblastoma and is required for GSC tumorigenesis.
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Quantitative profiling of pseudouridylation landscape in the human transcriptome
Nature Chemical Biology, 2023Pseudouridine (Ψ) is an abundant post-transcriptional RNA modification in ncRNA and mRNA. However, stoichiometric measurement of individual Ψ sites in human transcriptome remains unaddressed. Here we develop 'PRAISE', via selective chemical labeling of Ψ by bisulfite to induce nucleotide deletion signature during reverse transcription, to realize ...
Meiling Zhang +8 more
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