Results 151 to 160 of about 22,716 (169)
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Tackling PTEN induced putative kinase 1 in angiotensin II-induced myocardial injury
International Journal of Cardiology, 2021Hong Xie
exaly +3 more sources
Meta Gene, 2020
Abstract PINK1 codes for a serine/threonine-protein kinase located in the mitochondria. This protein contributes in the pathophysiology of both neurodegenerative diseases and cancer. Its transcription has been shown to be regulated by a natural occurring antisense (AS) RNA named PINK1-AS.
Hajar Yaghoobi +4 more
openaire +1 more source
Abstract PINK1 codes for a serine/threonine-protein kinase located in the mitochondria. This protein contributes in the pathophysiology of both neurodegenerative diseases and cancer. Its transcription has been shown to be regulated by a natural occurring antisense (AS) RNA named PINK1-AS.
Hajar Yaghoobi +4 more
openaire +1 more source
Physiology, 2023
PTEN-induced putative kinase 1 (PINK1) is an essential molecule in mitophagy process in mammalian cells. The primary purpose of this study was to determine the expression and subcellular localization of PINK1 under physiological fluidic conditions in endothelial cells (ECs) and elucidate the implication these phenomena in the endothelial homeostasis ...
Joon-Young Park +5 more
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PTEN-induced putative kinase 1 (PINK1) is an essential molecule in mitophagy process in mammalian cells. The primary purpose of this study was to determine the expression and subcellular localization of PINK1 under physiological fluidic conditions in endothelial cells (ECs) and elucidate the implication these phenomena in the endothelial homeostasis ...
Joon-Young Park +5 more
openaire +1 more source
Physiology
Cardiovascular (CVD) is the leading cause of death, afflicting 1 in 5 American adults, CVD a primary outcome of metabolic syndrome (MetS). MetS is defined as a cluster factor of conditions including obesity, hypertension, dyslipidemia, glucose intolerance with or without insulin resistance, and a proinflammatory or prothrombotic state. Thyroid hormone (
Jenifer Hernandez Garcia +2 more
openaire +1 more source
Cardiovascular (CVD) is the leading cause of death, afflicting 1 in 5 American adults, CVD a primary outcome of metabolic syndrome (MetS). MetS is defined as a cluster factor of conditions including obesity, hypertension, dyslipidemia, glucose intolerance with or without insulin resistance, and a proinflammatory or prothrombotic state. Thyroid hormone (
Jenifer Hernandez Garcia +2 more
openaire +1 more source
Circulation, 2012
Introduction: Oxidative damage (OxD) determined as protein adducts of 4-hydroxy-2-nonenal (HNE) is increased in gastrocnemius myofibers of patients with peripheral arterial disease (PAD) and correlates with disease progression. Mitochondria in PAD gastrocnemius exhibit structural damage and respiratory dysfunction; however, the
Panagiotis Koutakis +8 more
openaire +1 more source
Introduction: Oxidative damage (OxD) determined as protein adducts of 4-hydroxy-2-nonenal (HNE) is increased in gastrocnemius myofibers of patients with peripheral arterial disease (PAD) and correlates with disease progression. Mitochondria in PAD gastrocnemius exhibit structural damage and respiratory dysfunction; however, the
Panagiotis Koutakis +8 more
openaire +1 more source
International Journal of Biological Macromolecules
PTEN-induced putative kinase 1 (PINK1) is a key regulator of mitophagy, however, the relevant information remains poorly understood on aquatic animals. Here, a PINK1 gene was cloned, characterized and functionally studied in yellow catfish. PINK1 encoded a protein containing 570 amino acids, 2 functional domains.
Lanfei, Xiao +7 more
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PTEN-induced putative kinase 1 (PINK1) is a key regulator of mitophagy, however, the relevant information remains poorly understood on aquatic animals. Here, a PINK1 gene was cloned, characterized and functionally studied in yellow catfish. PINK1 encoded a protein containing 570 amino acids, 2 functional domains.
Lanfei, Xiao +7 more
openaire +2 more sources
2016
Stroke results from disturbance in blood flow to an area of the brain, leading to neuronal dysfunction and loss. Mitochondrial dysfunction and oxidative stress are critical factors in neuropathology of stroke. They have also been implicated in Parkinson's disease (PD). Select cases of PD are caused by homozygous mutations in the PINK1 gene. Critically,
openaire +1 more source
Stroke results from disturbance in blood flow to an area of the brain, leading to neuronal dysfunction and loss. Mitochondrial dysfunction and oxidative stress are critical factors in neuropathology of stroke. They have also been implicated in Parkinson's disease (PD). Select cases of PD are caused by homozygous mutations in the PINK1 gene. Critically,
openaire +1 more source
Journal of Ethnopharmacology
Chronic heart failure (CHF) is characterized by complex pathogenesis involving various pathogenic mechanisms such as dysregulated autophagy, mitochondrial dysfunction, cardiomyocyte apoptosis, and chronic inflammation. Ershen Zhenwu Decoction (ESZWD) is a traditional Chinese herbal formulation.
Xinyue Wang +8 more
openaire +2 more sources
Chronic heart failure (CHF) is characterized by complex pathogenesis involving various pathogenic mechanisms such as dysregulated autophagy, mitochondrial dysfunction, cardiomyocyte apoptosis, and chronic inflammation. Ershen Zhenwu Decoction (ESZWD) is a traditional Chinese herbal formulation.
Xinyue Wang +8 more
openaire +2 more sources
Phytomedicine
Adolescent depression is a prevalent and escalating public health concern. Z-Ligustilide (Z-LIG), a bioactive phthalide extracted from Angelica sinensis (Oliv.) Diels-a Chinese herbal medicine commonly used for its antidepressant effects-exhibits significant anti-inflammatory properties, extensive brain distribution, and low cytotoxicity. Nevertheless,
Tao Yi +13 more
openaire +2 more sources
Adolescent depression is a prevalent and escalating public health concern. Z-Ligustilide (Z-LIG), a bioactive phthalide extracted from Angelica sinensis (Oliv.) Diels-a Chinese herbal medicine commonly used for its antidepressant effects-exhibits significant anti-inflammatory properties, extensive brain distribution, and low cytotoxicity. Nevertheless,
Tao Yi +13 more
openaire +2 more sources