Results 11 to 20 of about 8,569 (252)

Pteridines in the Assessment of Neoplasia [PDF]

cclm, 1982
Biological processes which might explain the association of pteridine excretion with proliferation are still unknown. Difficulties in the analysis and the determination of naturally occurring pteridines are described. The best quantitative estimations were achieved when measurement of non-reduced forms was attempted.
HAUSEN, A., Wachter, H.
openaire   +4 more sources

Prospects for the use of sulfur-containing pteridines in toxic liver damage

Regulatory Mechanisms in Biosystems
The presented material describes the results of the purposeful search for the novel hepatoprotective agents among synthetic sulfur-containing pteridines. The studied compounds were obtained using previously described synthetic procedures.
N. Lohvinenko, V. Shvets, G. Berest, I. Nosulenko, O. Voskoboinik, H. Severina, S. Okovytyy, S. Kovalenko   +7 more
exaly   +3 more sources

New Syntheses of a Pteridine

Chemischer Informationsdienst, 1981
AbstractDie Uracilderivate (I) und (IV) reagieren mit Acetylendicarbonsäuredimethylester (II) zum Bis‐methoxycarbonyl‐dimethyl‐lumazin (III).
K. SENGA, Sadao Nishigaki, Kiyoko Fukami, M. ICHIBA, Hashime Kanazawa, Keiko Matsuyama, Shinobu Ogusu, Fumio Yoneda, Ryosuke Koga, Toyoko Ueno   +9 more
openalex   +3 more sources

In silico and in vivo screening of triamterene synthetic analogues as promising diuretics

Medičnì Perspektivi, 2022
The modification of lead-compound aimed to the increasing of activity, decrement of toxicity or improvement of selectivity is one of the most important methods used for elaboration of novel medications.
K.V. Sokolova, V.V. Stavytskyi , O.Yu. Voskoboinik , O.A. Podpletnya , S.I. Kovalenko   +4 more
doaj   +1 more source

Pteridine determination in human serum with special emphasis on HPLC methods with fluorimetric detection

Pteridines, 2017
Conjugated and unconjugated pteridines and their derivatives are important cofactors in cellular metabolism. Hence, the amount of unconjugated pteridines in biological fluids has been found to be modified as a result of several disorders. It is necessary
Espinosa-Mansilla Anunciación, Durán-Merás Isabel   +1 more
doaj   +1 more source

Synthesis, Anti-inflammatory and Antibacterial Activities of Novel Pyrazolo[4,3-g]pteridines.

Chemical and pharmaceutical bulletin, 2016
A novel series of 6-substituted pyrazolo[3,4-g]pteridines 2-9 and pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pteridin-2(3H)-one (thione) 10 and 11 was synthesized using the starting compound 3,7-dimethyl-1-phenylpyrazolo[4',3':5,6]pyrazino[2,3-d][1,3]oxazin-5 ...
Shawkat A. Abdel-Mohsen, T. El‐Emary, H. El-kashef   +2 more
semanticscholar   +1 more source

Age-dependance of pteridines in the malaria vector, Anopheles stephensi

Pteridines, 2017
Determining the accurate age of malaria vectors is crucial to measure the risk of malaria transmission. A group of fluorescent chemicals derived from a pyrimidine-pyrazine ring structure known as pteridines from the head, thorax and whole body of adult ...
Edalat Hamideh, Akhoundi Mohammad, Basseri Hamidreza   +2 more
doaj   +1 more source

Studies and Comparison of Urinary Pteridine Patterns in Dogs and Cats and their Alteration in Various Neoplasias and Virus Infections

Pteridines, 1989
Urinary excretion levels of five pteridines in healthy cats and dogs and in 14 groups of animals with tumours or virus infections were determined by HPLC after partial purification by ion exchange chromatography.
Goldberg M., Gassner F., Merkenschlager M.   +2 more
doaj   +1 more source

Novel Aminopyrimidine-2,4-diones, 2-Thiopyrimidine-4-ones, and 6-Arylpteridines as Dual-Target Inhibitors of BRD4/PLK1: Design, Synthesis, Cytotoxicity, and Computational Studies

Pharmaceuticals, 2023
Structural-based drug design and solvent-free synthesis were combined to obtain three novel series of 5-arylethylidene-aminopyrimidine-2,4-diones (4, 5a–c, 6a,b), 5-arylethylidene-amino-2-thiopyrimidine-4-ones (7,8), and 6-arylpteridines (9,10) as dual ...
Samar El-Kalyoubi, Samiha A. El-Sebaey, Sherin M. Elfeky, Hanan A. AL-Ghulikah, Mona S. El-Zoghbi   +4 more
doaj   +1 more source

Homology Cloning of GTP-cydohydrolase I from Fungi and Plants by Reverse-transcription PCR Using a General Set of Degenerate Primers

Pteridines, 1995
Unconjugated pteridines are present in fungi, algae and plants. However, the functions of pteridines in these organisms are not thoroughly investigated. The biosynthesis follows the same steps as were shown for animals and eubacteria.
Maier Josef, Werner Thomas, Ninnemann Helga   +2 more
doaj   +1 more source