Results 11 to 20 of about 8,074 (264)
Pteridines, 2004 2,4-Disubstituted pteridine derivatives (1-3) react with acyl radicals very selectively in position 7 by a nucleophilic Substitution mechanism (4-10).
Döring Thomas +2 more
exaly +2 more sources
In silico and in vivo screening of triamterene synthetic analogues as promising diuretics
Medičnì Perspektivi, 2022 The modification of lead-compound aimed to the increasing of activity, decrement of toxicity or improvement of selectivity is one of the most important methods used for elaboration of novel medications.
K.V. Sokolova +4 more
doaj +1 more source
Pteridines in the Assessment of Neoplasia [PDF]
cclm, 1982 Biological processes which might explain the association of pteridine excretion with proliferation are still unknown. Difficulties in the analysis and the determination of naturally occurring pteridines are described. The best quantitative estimations were achieved when measurement of non-reduced forms was attempted.
HAUSEN, A., Wachter, H.
openaire +4 more sources
Diversity oriented synthesis : substitution at C5 in unreactive pyrimidines by Claisen rearrangement and reactivity in nucleophilic substitution at C2 and C4 in pteridines and pyrido[2,3-d]pyrimidines [PDF]
, 2011 Diversity oriented synthesis of fused pyrimidines leads to scaffolds with many biological activities. In the case of the preparation of pyrido[2,3-d]pyrimidines from 2-alkylthiopyrimidines, the formation of a new carbon-carbon bond at C5 is required, a ...
Adcock, Jonathan Paul +3 more
core +1 more source
Pteridines, 2017 Conjugated and unconjugated pteridines and their derivatives are important cofactors in cellular metabolism. Hence, the amount of unconjugated pteridines in biological fluids has been found to be modified as a result of several disorders. It is necessary
Espinosa-Mansilla Anunciación +1 more
doaj +1 more source
Pteridine-2,4-diamine derivatives as radical scavengers and inhibitors of lipoxygenase that can possess anti-inflammatory properties [PDF]
, 2015 BACKGROUND: Reactive oxygen species are associated with inflammation implicated in cancer, atherosclerosis and autoimmune diseases. The complex nature of inflammation and of oxidative stress suggests that dual-target agents may be effective in combating ...
Hadjipavlou-Litina, D +4 more
core +1 more source
Age-dependance of pteridines in the malaria vector, Anopheles stephensi
Pteridines, 2017 Determining the accurate age of malaria vectors is crucial to measure the risk of malaria transmission. A group of fluorescent chemicals derived from a pyrimidine-pyrazine ring structure known as pteridines from the head, thorax and whole body of adult ...
Edalat Hamideh +2 more
doaj +1 more source
Pteridines, 1989 Urinary excretion levels of five pteridines in healthy cats and dogs and in 14 groups of animals with tumours or virus infections were determined by HPLC after partial purification by ion exchange chromatography.
Goldberg M. +2 more
doaj +1 more source
An Efficient Synthesis of 2'-O-(β-D-Ribofuranosyl)biopterin [PDF]
, 2008 N(2)-(N,N-Dimethylaminomethylene)-3-[2-(4-nitrophenyl)ethyl]-1',2'-di-O (trimethylsilyl)biopterin (4) was prepared from biopterin (1a, 86% overall yield) in 5 steps. Glycosylation of 4 with 1,2,3,5-tetra-O-acetyl-β D-ribofuranose (5a) and its 2,3,5-tri-O-
Fujita, Hiroshi +5 more
core +1 more source