Structural and mechanistic insights into the divergence of pterin deaminase and sepiapterin deaminase [PDF]
Applied Microbiology and BiotechnologyPterin deaminase and sepiapterin deaminase are key members of the amidohydrolase superfamily and play essential roles in pteridine metabolism across a wide range of biological systems.
Nivetha Shanmuganathan +7 more
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Comparative routes to 7-carboxymethyl-pterin: A useful medicinal chemistry building block
Pteridines, 2022 Pterins, such as folate and biopterin, and their derivatives hold significant importance given their biological relevance, as well as the numerous pterin-based inhibitors developed for targeting various biological targets. For this reason, pterins can be
Bennett Zachary +2 more
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Mechanism of soil bacteria (Cupriavidus sp. LA-1) for degrading natural pterin and lumazine pigments [PDF]
Communications BiologyDiverse microbial metabolic mechanisms help maintain the environmental dynamics of natural compounds in biogeochemical cycles. This study revealed the bacterial mechanism for degrading pterin and lumazine compounds, which are natural cofactors and ...
Yuki Doi, Norifumi Maeda, Naoki Takaya
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A virtual screening and molecular dynamics approach in search of novel antibiotic chemotypes. [PDF]
PLoS ONEDue to the constantly evolving threat of antibiotic resistance, there is a dire need for novel antibacterial agents. Dihydropteroate synthase (DHPS) is a key bacterial enzyme which has been targeted for nearly a century as a means of selective treatment ...
Tahira Noor +9 more
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Synthesis, Redox and Spectroscopic Properties of Pterin of Molybdenum Cofactors
Molecules, 2022 Pterins are bicyclic heterocycles that are found widely across Nature and are involved in a variety of biological functions. Notably, pterins are found at the core of molybdenum cofactor (Moco) containing enzymes in the molybdopterin (MPT) ligand that ...
Partha Basu, Kyle J. Colston
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Theoretical Study on the Relative Energies of Neutral Pterin Tautomers
Pteridines, 2008 Current literature lists the lactam and lactim tautomers as the only major contributors to aqueous pterin structures. Density functional theory calculations were used to determine whether there are other significant neutral tautomers of pterin ...
Christopher Martin, Michael Soniat
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Comparative metabolism of conjugated and unconjugated pterins in Crithidia, Leishmania and African trypanosomes. [PDF]
PLoS Neglected Tropical DiseasesMammalian cells synthesise tetrahydrobiopterin de novo, an essential cofactor for hydroxylation of aromatic amino acids, cleavage of ether lipids and the synthesis of nitric oxide.
Han B Ong, Susan Wyllie, Alan H Fairlamb
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Theoretical Study on the Relative Energies of Anionic Pterin Tautomers
Pteridines, 2009 Pterins exist as several tautomeric forms and behave as weak acids in aqueous solutions. Therefore, several acidbase equilibria may be present. For several pterin derivatives, the range of the experimental pKa lies in the range 6-8.
Christopher Martin, Michael Soniat
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Pterin-Based Red Coloration Predicts the Outcome of Male–Male Competition in Guinan Toad-Headed Lizard [PDF]
AnimalsAnimal coloration offers a unique opportunity to explore the evolutionary mechanisms underlying phenotypic diversity. Conspicuous coloration caused by pigments plays a crucial role in social signaling across multiple species by conveying information ...
Xiao Xiao +8 more
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Metabolic reprogramming of endothelial-related pathways in COVID-19 patients treated with hyperbaric oxygen therapy: a randomized clinical trial [PDF]
Scientific ReportsCOVID-19, caused by SARS-CoV-2, is increasingly recognized as a systemic disorder with inflammation, endothelial dysfunction, and metabolic perturbations.
Natalia Jermakow +8 more
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