Results 11 to 20 of about 9,547 (224)
Inactivation of tyrosinase photoinduced by pterin
Biochemical and Biophysical Research Communications, 2012 Tyrosinase catalyzes in mammals the first and rate-limiting step in the biosynthesis of the melanin, the main pigment of the skin. Pterins, heterocyclic compounds able to photoinduce oxidation of DNA and its components, accumulate in the skin of patients suffering from vitiligo, a chronic depigmentation disorder in which the protection against UV ...
María Laura Dántola, Andrés H Thomas
exaly +4 more sources
Age-Dependent Variation in Blood Biopterin Peaks Following Oral Tetrahydrobiopterin Administration in Phenylketonuria. [PDF]
J Inherit Metab DisABSTRACT The correct diagnosis of tetrahydrobiopterin (BH4, sapropterin dihydrochloride)‐responsive phenylketonuria (PKU) and treatment with BH4 are important for prognosis and quality of life. We examined whether age affects biopterin bioavailability following oral BH4 administration in PKU and whether this influences BH4 responsiveness.
Kitayama K +5 more
europepmc +2 more sources
Pterin-based pigmentation in animals [PDF]
Biology Letters, 2021 Pterins are one of the major sources of bright coloration in animals. They are produced endogenously, participate in vital physiological processes and serve a variety of signalling functions. Despite their ubiquity in nature, pterin-based pigmentation has received little attention when compared to other major pigment classes.
Pedro Andrade, Miguel Carneiro
openaire +2 more sources
Synthesis, Characterization and Chlorination of 4-(Pentyloxy)-7-(prop-2-yn-1-yloxy)pteridin-2-amine
Molbank, 2023 A new alkyne functionalized pterin derivative was synthesized through a reaction of 7-chloropterin with propargyl alcohol in the presence of sodium hydride.
Jevy V. Correia +2 more
doaj +1 more source
Comparison of Pteridine Normalization Methods in Urine for Detection of Bladder Cancer
Diagnostics, 2020 Pterin compounds belong to the group of biomarkers for which an increase in interest has been observed in recent years. Available literature data point to this group of compounds as potential biomarkers for cancer detection, although the biochemical ...
Piotr Kośliński +6 more
doaj +1 more source
Exploring the scope of DBU-promoted amidations of 7-methoxycarbonylpterin
Beilstein Journal of Organic Chemistry, 2020 The synthetic utility of pterins is often hampered by the notorious insolubility of this heterocycle, slowing the development of medicinally relevant pteridine derivatives.
Anna R. Bockman, Jeffrey M. Pruet
doaj +1 more source
Ethnic Bridging of Sepiapterin in Chinese and Korean Populations Based on Predictions From Genetic Polymorphism of Breast Cancer Resistance Protein. [PDF]
Clin Transl SciABSTRACT Ethnic differences are crucial when considering the efficacy, safety, and dose of pharmaceuticals across diverse populations. The International Council for Harmonization of Technical Requirements for Pharmaceuticals for Human Use (ICH) guideline E5 addresses the acceptability of extrapolating foreign clinical data taking ethnic factors into ...
Gao L, Smith N, Kong R.
europepmc +2 more sources
Results in Chemistry, 2023 Antimicrobial resistance has rendered the sulfonamide class of antibiotics obsolete. An additional binding site on the dihydropteroate synthase (DHPS) enzyme, i.e., the pterin binding site, has been shown to be a valid alternative to the well-known para ...
Maryké Shaw +3 more
doaj +1 more source
Acta Crystallographica Section E, 2013 In the title complex, [Ni(C8H5N5O3)(C2H8N2)(C3N2H4)]·2H2O, a tridentate 2-amino-7-methyl-4-oxidopteridine-6-carboxylate (pterin) ligand, a bidentate ancillary ethane-1,2-diamine (en) ligand and a monodentate 1H-imidazole (im) ligand complete a ...
Siddhartha S. Baisya, Parag S. Roy
doaj +1 more source
Making Moco: A Personal History
Molecules, 2023 This contribution describes the path of my nearly forty-year quest to understand the special ligand coordinated to molybdenum and tungsten ions in their respective enzymes.
Sharon J. Nieter Burgmayer
doaj +1 more source