Results 51 to 60 of about 4,628 (262)

Analysis of Synaptic Proteins in the Cerebrospinal Fluid as a New Tool in the Study of Inborn Errors of Neurotransmission [PDF]

, 2011
In a few rare diseases, specialised studies in cerebrospinal fluid (CSF) are required to identify the underlying metabolic disorder. We aimed to explore the possibility of detecting key synaptic proteins in the CSF, in particular dopaminergic and ...
A García-Cazorla, A García-Cazorla, A García-Cazorla, A Ormazabal, A Rustom, A Zougman, Ana Pérez, Angels García-Cazorla, C Mei De, Carlos Ortez, D Biou, E Thouvenot, EA Bolan, EA Cartier, FA Witzmann, I Corradini, I Marín-Valencia, J Eriksen, JA Kauer, JC Heyden Van Der, KE Sorra, LA Egaña, M Serrano, MA Willemsen, MG Harrington, Rafael Artuch, SB Glickstein, Sofia T. Duarte, TC Südhof, TC Südhof, TJ Volz, TJ Volz   +31 more
core   +1 more source

Binding affinities of folic acid and related pterins with biological macromolecules under physiological conditions

Pteridines, 2015
Folic acid and pterin derivatives are important heterocyclic compounds found in a variety of biological systems and have been shown to be photochemically active. Understanding the amount of binding that various pterins have with biological macromolecules
Soniat Michael, Martin Christopher B.
doaj   +1 more source

Drug Discovery Applications of Nitroso (Hetero)Arene Derivatives

ChemPlusChem, Volume 90, Issue 12, December 10, 2025.
Nitroso (hetero)aromatic compounds are bioactive molecules with antiviral, anticancer, neuroprotective, and antimicrobial properties. This review highlights their mechanisms of action—oxidative stress, DNA damage, and enzyme inhibition—alongside synthesis, structure–activity relationships, and toxicity challenges, offering insight into their ...
Silvia Roscales, Aurelio G. Csáky
wiley   +1 more source

First Synthesis of Asperopterin A, an Isoxanthopterin Glycoside from Aspergillus Oryzae [PDF]

, 2013
The key precursor, N-2-(N,N -dimethylaminomethylene)-6-hydroxymethyl-8-methyl-3-[2-(4-nitrophenyl)ethyl]-7-xanthopterin (16) was efficiently prepared from 2,5-diamino-6-methylamino-3H-pyrimidin-4-one (5) and ethyl 3-(tert-butyldimethylsilyloxy)-2 ...
Hanaya, Tadashi, Yamamoto, Hiroshi
core   +1 more source

Diagnosis of tetrahydrobiopterin deficiency using filter paper blood spots: further development of the method and 5 years experience [PDF]

, 2018
In every newborn with even mild hyperphenylalaninemia (HPA) tetrahydrobiopterin (BH4) deficiencies need to be excluded as soon as possible. Differential diagnosis is most commonly performed by analysis of urinary neopterin and biopterin.
Abu Seda, Bettina, Blau, Nenad, Hoffmann, Georg, Opladen, Thomas, Rassi, Anahita, Thöny, Beat   +5 more
core  

Effects of Germination on the Fatty Acid, Folate, and Mineral Levels in Quinoa

Food Science &Nutrition, Volume 13, Issue 12, December 2025.
This study analyzed the change of the key nutrients in quinoa during its short‐term germination process. The results showed that germination significantly increases the content of folate, protein, and trace minerals, thereby maximizing its nutritional properties for promoting neural development.
Boyuan Li, Ting Wang, Muhui Wang, Yueying Zhang, Pak‐Ho Wong, Yi Wang   +5 more
wiley   +1 more source

Biochemistry and biosynthesis of insect pigments

European Journal of Entomology, 2014
The functional role and commercial importance of insect pigments have been studied for well over a century. They are classified into those synthesized by insects, which include anthraquinones, aphins, pterins, tetrapyrroles, ommochromes, melanins and ...
Gulsaz SHAMIM, Sanjeev K. RANJAN, Dev M. PANDEY, Ranganathan RAMANI   +3 more
doaj   +1 more source

Reversal Potential of Multidrug Antibiotic Resistance in Cutibacterium acnes by Ethanol Extracts of Rhubarb

MicrobiologyOpen, Volume 14, Issue 6, December 2025.
1. Ethanol extract of Rhubarb effectively reversed regular clinical antibiotic resistance, and was confirmed by growth curves and oxidative markers. 2. Reversal effects were observed with erythromycin (1000‐fold), clindamycin (250‐fold) and tetracycline (2–4‐fold). 3.
Doudou Yang, Yu Cui, Sen Zhu, Ruoliang Wang, Haijun Xu, Guanjie Zhao, Dandan Zhang, Yinku Liang   +7 more
wiley   +1 more source

Eumelanin and pheomelanin are predominant pigments in bumblebee (Apidae: Bombus) pubescence [PDF]

, 2017
Background: Bumblebees (Hymenoptera: Apidae: Bombus) are well known for their important inter- and intra-specific variation in hair (or pubescence) color patterns, but the chemical nature of the pigments associated with these patterns is not fully ...
Alberto, Jorge, Ornosa Gallego, Concepción, Polidori, Carlo   +2 more
core   +2 more sources

RRP12 Variants Are Associated With Autosomal Recessive Brain Calcifications

Movement Disorders, Volume 40, Issue 12, Page 2792-2803, December 2025.
Abstract Background Primary brain calcifications are observed in several inherited diseases due to different pathogenic mechanisms, including the disruption of the neurovascular unit, mitochondrial dysfunction, and impaired nucleic acid metabolism.
Edoardo Monfrini, Paola Rinchetti, Mathieu Anheim, Anna Klingseisen, Ouhaid Lagha‐Boukbiza, Zhidong Cen, Dehao Yang, Xinhui Chen, Reza Maroofian, Henry Houlden, Gioia Cappelletti, Anne‐Claire Richard, Olivier Quenez, Camilo Toro, Steven J. Frucht, Francesco Lotti, Wei Luo, David Hunt, Gael Nicolas, Giulietta M. Riboldi   +19 more
wiley   +1 more source