Direct coordination of pterin to Fe II enables neurotransmitter biosynthesis in the pterin-dependent hydroxylases [PDF]
Proceedings of the National Academy of Sciences, 2021 Significance The mononuclear pterin-dependent nonheme iron enzymes catalyze the rate-limiting step in neurotransmitter biosynthesis and are essential in maintaining proper brain function. These enzymes utilize molecular oxygen, a redox active pterin cofactor, and a ferrous active site to generate an Fe
Shyam R. Iyer +13 more
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Major Reference Works., 2011 Wiley is pleased to announce the recent acquisition of the prestigious Encyclopedia of Life Sciences (ELS) from the Nature Publishing Group.
"The most ambitious single source reference source ever produced in the biological sciences"
—American Reference Books Annual
Spanning the entire spectrum of life science ...
Peter Hegemann, Carol Dieckmann
wiley +1 more source
Angewandte Chemie, EarlyView.This review highlights an emerging anticancer approach integrating platinum agents into photodynamic therapy (PDT) and photoactivated chemotherapy (PACT) systems, further augmented by cancer cell membrane‐ and organelle‐targeting. By directing photoactivated platinum complexes from nontargeted distribution to cancer cells or defined subcellular sites ...
Shu Chen +3 more
wiley +2 more sources
Pteridines, 1999 A series of new 6-substituted 2,4-diaminopteridines (3-23) and pterins (26-43) have been synthesized by nucleophilic displacement reactions at the side chain of 6-bromomethyl-2,4-diaminopteridine (2) and 6- bromomethylpterin (25) using various types of 0-
Traub Hermann, Pfleiderer Wolfgang
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A model to understand type I oxidations of biomolecules photosensitized by pterins [PDF]
, 2023 Photosensitized oxidations, in part responsible for the harmful effect of UV and visible radiation on biological systems, can take place through type I (generation of radicals) and type II (singlet oxygen) mechanisms.
Lorente, Carolina +4 more
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Pterins and affective disorders [PDF]
, 2007 The pathophysiology of affective disorders is largely unknown. In patients with various affective disorders the activity of pterins and related amino acids were investigated before and after clinical treatment.
Hoekstra, R (Rosa), Hoekstra, R. (Rocco)
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Tryptophan oxidation photosensitized by pterin
Free Radical Biology and Medicine, 2013 Pterins are normal components of cells and they have been previously identified as good photosensitizers under UV-A irradiation, inducing DNA damage and oxidation of nucleotides. In this work, we have investigated the ability of pterin (Ptr), the parent compound of oxidized pterins, to photosensitize the oxidation of another class of biomolecules ...
Thomas, Andrés Héctor +6 more
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The Journal of Infectious Diseases, 2021 Abstract Background Cerebral malaria (CM) pathogenesis remains incompletely understood. Having shown low systemic levels of tetrahydrobiopterin (BH4), an enzymatic cofactor for neurotransmitter synthesis, we hypothesized that BH4 and BH4-dependent neurotransmitters would likewise be low in ...
Matthew P Rubach +13 more
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Photosensitization of peptides and proteins by pterin derivatives
Pteridines, 2017 Proteins are one of the preferential targets of the photosensitized damaging effects of ultraviolet (UV) radiation on biological system. Pterins belong to a family of heterocyclic compounds, which are widespread in living systems and participate in ...
Dantola Maria Laura +5 more
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Unveiling Photodegradation and Photosensitization Mechanisms of Unconjugated Pterins
, 2023 Unconjugated pterins are ubiquitous molecules that participate in countless enzymatic processes and are potentially involved in the photosensitization of singlet oxygen, amino acids, and nucleotides.
Corral, Ines, +5 more
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