Results 31 to 40 of about 2,236 (202)
Pterin determination in cerebrospinal fluid: state of the art
Pteridines, 2017 The analysis of pterins in the cerebrospinal fluid (CSF) is mandatory for the etiologic diagnosis of inborn errors of dopamine and serotonin metabolism.
Guibal Pierre +3 more
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Exploring the scope of DBU-promoted amidations of 7-methoxycarbonylpterin
Beilstein Journal of Organic Chemistry, 2020 The synthetic utility of pterins is often hampered by the notorious insolubility of this heterocycle, slowing the development of medicinally relevant pteridine derivatives.
Anna R. Bockman, Jeffrey M. Pruet
doaj +1 more source
Direct coordination of pterin to Fe II enables neurotransmitter biosynthesis in the pterin-dependent hydroxylases [PDF]
Proceedings of the National Academy of Sciences, 2021 Significance The mononuclear pterin-dependent nonheme iron enzymes catalyze the rate-limiting step in neurotransmitter biosynthesis and are essential in maintaining proper brain function. These enzymes utilize molecular oxygen, a redox active pterin cofactor, and a ferrous active site to generate an Fe
Shyam R. Iyer +13 more
openaire +2 more sources
Angewandte Chemie, EarlyView.This review highlights an emerging anticancer approach integrating platinum agents into photodynamic therapy (PDT) and photoactivated chemotherapy (PACT) systems, further augmented by cancer cell membrane‐ and organelle‐targeting. By directing photoactivated platinum complexes from nontargeted distribution to cancer cells or defined subcellular sites ...
Shu Chen +3 more
wiley +2 more sources
Pteridines, 1999 A series of new 6-substituted 2,4-diaminopteridines (3-23) and pterins (26-43) have been synthesized by nucleophilic displacement reactions at the side chain of 6-bromomethyl-2,4-diaminopteridine (2) and 6- bromomethylpterin (25) using various types of 0-
Traub Hermann, Pfleiderer Wolfgang
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A model to understand type I oxidations of biomolecules photosensitized by pterins [PDF]
, 2023 Photosensitized oxidations, in part responsible for the harmful effect of UV and visible radiation on biological systems, can take place through type I (generation of radicals) and type II (singlet oxygen) mechanisms.
Lorente, Carolina +4 more
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Pterins and affective disorders [PDF]
, 2007 The pathophysiology of affective disorders is largely unknown. In patients with various affective disorders the activity of pterins and related amino acids were investigated before and after clinical treatment.
Hoekstra, R (Rosa), Hoekstra, R. (Rocco)
core +1 more source
Tryptophan oxidation photosensitized by pterin
Free Radical Biology and Medicine, 2013 Pterins are normal components of cells and they have been previously identified as good photosensitizers under UV-A irradiation, inducing DNA damage and oxidation of nucleotides. In this work, we have investigated the ability of pterin (Ptr), the parent compound of oxidized pterins, to photosensitize the oxidation of another class of biomolecules ...
Thomas, Andrés Héctor +6 more
openaire +3 more sources
The Journal of Infectious Diseases, 2021 Abstract Background Cerebral malaria (CM) pathogenesis remains incompletely understood. Having shown low systemic levels of tetrahydrobiopterin (BH4), an enzymatic cofactor for neurotransmitter synthesis, we hypothesized that BH4 and BH4-dependent neurotransmitters would likewise be low in ...
Matthew P Rubach +13 more
openaire +5 more sources
Photosensitization of peptides and proteins by pterin derivatives
Pteridines, 2017 Proteins are one of the preferential targets of the photosensitized damaging effects of ultraviolet (UV) radiation on biological system. Pterins belong to a family of heterocyclic compounds, which are widespread in living systems and participate in ...
Dantola Maria Laura +5 more
doaj +1 more source