Results 61 to 70 of about 113,584 (291)

Acute Hypercapnia/Ischemia Alters the Esterification of Arachidonic Acid and Docosahexaenoic Acid Epoxide Metabolites in Rat Brain Neutral Lipids. [PDF]

, 2020
In the brain, approximately 90% of oxylipins are esterified to lipids. However, the significance of this esterification process is not known. In the present study, we (1) validated an aminopropyl solid phase extraction (SPE) method for separating ...
Bazinet, Richard P, Hammock, Bruce D, Metherel, Adam H, Newman, John W, Otoki, Yurika, Pedersen, Theresa, Taha, Ameer Y, Yang, Jun   +7 more
core   +1 more source

Web-enabled knowledge-based analysis of genetic data [PDF]

, 2001
We present a web-based implementation of GenePath, an intelligent assistant tool for data analysis in functional genomics. GenePath considers mutant data and uses expert-defined patterns to find gene-to-gene or gene-to-outcome relations.
Bratko, Ivan, Demšar, Janez, Halter, John A., Juvan, Peter, Kuspa, Adam, Shaulsky, Gad, Zupan, Blaz   +6 more
core   +2 more sources

T Cell Exhaustion in Cancer Immunotherapy: Heterogeneity, Mechanisms, and Therapeutic Opportunities

Advanced Science, EarlyView.
T cell exhaustion limits immunotherapy efficacy. This article delineates its progression from stem‐like to terminally exhausted states, governed by persistent antigen, transcription factors, epigenetics, and metabolism. It maps the exhaustion landscape in the TME and proposes integrated reversal strategies, providing a translational roadmap to overcome
Yang Yu, Xiaoyu Yao, Qingyang Wang, Mengrui Yang, Runze Li, Jiangjiang Qin, Jing Zhuang, Changgang Sun   +7 more
wiley   +1 more source

Influence of dietary linseed and sunflower oil on sensory characteristics of rainbow trout (Oncorhynchus mykiss)

Czech Journal of Animal Science, 2006
This study describes the effects of dietary linseed and sunflower oil on the sensory characteristics of rainbow trout (Oncorhynchus mykiss) fillets. Rainbow trout were fed a diet containing either 2.5% or 5% of linseed or sunflower oil or 5% mixture of ...
Z. Drobná, J. Zelenka, E. Mrkvicová, D. Kladroba   +3 more
doaj   +1 more source

The ethanolamide metabolite of DHA, docosahexaenoylethanolamine, shows immunomodulating effects in mouse peritoneal and RAW264.7 macrophages: evidence for a new link between fish oil and inflammation [PDF]

, 2011
Several mechanisms have been proposed for the positive health effects associated with dietary consumption of long-chain n-3 PUFA (n-3 LC-PUFA) including DHA (22 : 6n-3) and EPA (20 : 5n-3).
Attya, M., Balvers, M.G.J., Gabriele, B., Gruppen, H., Meijerink, J., Plastina, P., Poland, M.C.R., Vincken, J.P., Witkamp, R.F.   +8 more
core   +3 more sources

Dysregulation of Oral Microbial Eicosapentaenoic Acid Induced by Chronic Restraint Stress Exacerbates Periodontitis via M1 Macrophage Polarization

Advanced Science, EarlyView.
ABSTRACT The intricate interplay between chronic psychological stress and periodontitis, mediated by oral microbiota and macrophage polarization, remains largely enigmatic. Here, we demonstrate that chronic restraint stress (CRS) exacerbates periodontitis by inducing oral microbial dysbiosis and a consequential shift in host metabolism.
Shihong Luo, Fangzhi Lou, Peiran Yang, Yu Zhang, Li Yan, Yunmei Dong, Bing Yang, Haiyang Wang, Yiyun Liu, Juncai Pu, Richard D. Cannon, Peng Xie, Ping Ji, Xin Jin   +13 more
wiley   +1 more source

Influence of n-3 and n-6 polyunsaturated fatty acids on sensory characteristics of chicken meat

Czech Journal of Animal Science, 2008
The relationship between different levels of n-6 and n-3 PUFA in chicken breast and thigh meat and sensory characteristics of meat was studied. Chickens were fed diets containing 1, 3, 5 or 7 percent of oil made of seeds either of the linseed cultivar ...
J. Zelenka, A. Jarošová, D. Schneiderová   +2 more
doaj   +1 more source

Assessment of the Consequences of Dental Caries on the Body Mass Index in Children using the Pufa Index [PDF]

Journal of Clinical and Diagnostic Research, 2018
Introduction: Dental caries continues to exert a significant influence on children’s overall health and the effect of untreated dental caries impacts dental health more than the presence of caries itself. Aim: To investigate the effect of consequences of
Nikita Vinod Dandekar, J Jasmin Winnier, Uma B Dixit   +2 more
doaj   +1 more source

Polyunsaturated fatty acid-derived lipid mediators and T cell function [PDF]

, 2014
Copyright © 2014 Nicolaou, Mauro, Urquhart and Marelli-Berg . This is an open- access article distributed under the terms of the Creative Commons Attribution License (CC BY) .
Marelli-Berg, F, Mauro, C, Nicolaou, A, Urquhart, P   +3 more
core   +3 more sources

TrxR2 Lactylation Facilitates Mitochondrial Protection and Endothelial Ferroptosis Resistance in Diabetic Cardiomyopathy

Advanced Science, EarlyView.
TrxR2 deletion in diabetic mice suppresses TUFM‐AMPK‐FUNDC1‐dependent mitophagy in endothelial cells, resulting in SCP2 upregulation and mitochondrial translocation of ACSL4. Mitochondrial ACSL4 promotes mitochondrial eicosanoid biosynthesis and ferroptosis, thereby aggravating cardiac microvascular injury and diabetic cardiomyopathy.
Su Li, Muyin Liu, Chao Chen, Xinyan Li, Xiaopei Yan, Wentao Zhu, Wenyan Qiu, Qiyu Li, Xiangyu Sun, Chao Huang, Ming Yin, Zhangwei Chen, Yao Lu, Junbo Ge, Xiangqing Kong, Juying Qian, Yuqiong Chen   +16 more
wiley   +1 more source