Results 221 to 230 of about 8,097,471 (281)

A novel interaction between aquaporin 1 and caspase-3 in pulmonary arterial smooth muscle cells.

Am J Physiol Lung Cell Mol Physiol
Niedermeyer S, Yun X, Trujillo M, Jiang H, Andrade MR, Kolb TM, Suresh K, Damarla M, Shimoda LA.   +8 more
europepmc   +1 more source

Dual‐Targeting Biomimetic Nanozymes Loaded Microneedle Patch Promotes Scarless Wound Healing Through Anti‐Inflammatory and Anti‐Fibrotic Effects

Advanced Science, Volume 13, Issue 62, 9 November 2026.
This study developed a dual‐targeting biomimetic nanozyme hybrid system (Cu‐CeO2@ABs‐FTP) and integrated it with HAMA hydrogel to fabricate a microneedle patch (CAF@MN). The patch promotes fibroblast‐mediated wound repair, targets macrophages to induce M2 polarization, and targets myofibroblasts to exert anti‐fibrotic effects, thereby enabling rapid ...
Hongyi Zhang, Jinwei Li, Shan Hua, Shengming Wu, Chenlong He, Yuan Zhu, Ming Yin, Han Zhou, Huawei Liu, Chika Hasegawa, Jun Lyu, Keyue Xiao, Hua Jiang, Yilong Wang, Yuxin Qian   +14 more
wiley   +1 more source

Mechanism of anti-remodelling action of treprostinil in human pulmonary arterial smooth muscle cells. [PDF]

PLoS One, 2018
Lambers C, Kornauth C, Oberndorfer F, Boehm PM, Tamm M, Klepetko W, Roth M.   +6 more
europepmc   +1 more source

Establishment and Validation of a Model of Indwelling Nasogastric Tube in Patients After Acute Ischemic Stroke

Brain and Behavior, Volume 16, Issue 11, November 2026.
ABSTRACT Background Dysphagia is common after stroke, and accurately predicting its duration is essential for guiding therapeutic decisions. Timely indwelling nasogastric tube (NGT) placement is critical for patient prognosis. The purpose of this study was to develop and validate a predictive model for indwelling NGT requirements in patients with acute
Yaying Zeng, Wenbo Zhang, Yudi Han, Yijia Ye, Peiliang Zhang, Wujie Shi, Jianbin Weng, Zhipeng Shen, Zhi‐Lin Chen   +8 more
wiley   +1 more source

Giant Cervicothoracic Ganglioneuroma Misdiagnosed as Neurofibroma on Core Needle Biopsy: Transcervical Resection and Postoperative Neurological Sequelae: A Case Report

Clinical Case Reports, Volume 14, Issue 11, November 2026.
ABSTRACT Ganglioneuroma (GN) may be misdiagnosed as neurofibroma when core needle biopsy samples only contain Schwannian stroma without mature ganglion cells. Even giant cervicothoracic GNs may be resectable through a transcervical approach alone.
Omar Daas, Somaya Al Kiswani, Mohammad Z. Al‐Qaisi, Ahmad Daas, Ashjan Al Shakkah, Sohaib Salahat, Abdullah Nofal   +6 more
wiley   +1 more source

In Silico Clinical Trials in Drug Development: Virtual Patients, Applications, and Regulatory Convergence

Clinical Pharmacology &Therapeutics, Volume 120, Issue 5, Page 1181-1194, November 2026.
Conventional clinical trials remain the benchmark for evaluating therapeutic safety and efficacy, yet they are constrained by escalating costs, withdrawal over the extended follow‐up periods, recruitment difficulties, ethical limits, and a restricted ability to characterize heterogeneous populations.
Maximilian Balmus, Sheng‐Ya Wang, Edward W. G. Ashton, Rosie K. Barrows, Molly Monks, Yuzhang Ge, Arthur Lefebvre, Steven A. Niederer   +7 more
wiley   +1 more source

FSP1 as the convergent hub of autophagy and ubiquitination governing ferroptosis in monocrotaline‐induced pulmonary arterial hypertension

Clinical and Translational Medicine, Volume 16, Issue 11, November 2026.
Background: The crosstalk between autophagy and ferroptosis in pulmonary arterial hypertension (PAH) remains unclear. We investigated the role of FSP1 as a critical link between these processes. Methods and Findings: Mechanistically, we identified that FSP1 degradation is dually regulated by NBR1‐mediated autophagic flux and RNFT1‐dependent K63‐linked ...
Dandan Chen, Qi Jin, Lei Zhang, Wenzhi Pan, Daxin Zhou, Junbo Ge, Lihua Guan   +6 more
wiley   +1 more source

Inactivation of carboxyl terminus of Hsc70-interacting protein prevents hypoxia-induced pulmonary arterial smooth muscle cells proliferation by reducing intracellular Ca²⁺ concentration. [PDF]

Pulm Circ, 2019
Dong F, Zhang J.
europepmc   +1 more source

Quercetin and Cardiovascular Health: An Evidence‐Based Review of Risk Factors and Treatments

Food Science &Nutrition, Volume 14, Issue 11, November 2026.
Quercetin is a naturally occurring polyphenolic phytochemical distributed in fruits and vegetables. Quercetin, as a flavonoid, showed significant antioxidant capabilities and potential therapeutic effects on CVD risk factors. Quercetin reduces cardiac hypertrophy and apoptosis in cardiomyocytes by modulating critical signaling pathways.
Mohammad Reza Khazdair, Shima Jafari, Melika Shoghi   +2 more
wiley   +1 more source