Results 251 to 260 of about 8,097,471 (281)
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Sodium–Calcium Exchanger in Pulmonary Artery Smooth Muscle Cells
Annals of the New York Academy of Sciences, 2007Abstract: The expression and function of the Na+/Ca2+ exchanger (NCX) in the regulation of intracellular Ca2+ homeostasis have been well studied in cardiac, skeletal, and systemic vascular myocytes, but not in pulmonary artery smooth muscle cells (SMCs).
Yun-Min, Zheng, Yong-Xiao, Wang
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Membrane properties of smooth muscle cells in pulmonary arteries of the rat
American Journal of Physiology-Heart and Circulatory Physiology, 1982Electrical properties of the membrane of smooth muscle cells in the rat main pulmonary artery (MPA) and a small pulmonary artery (SPA) were compared. MPA and SPA differed in several important respects, suggesting characteristic quantitative and qualitative differences in membrane properties.
H, Suzuki, B M, Twarog
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Effect of cold preservation on pulmonary arterial smooth muscle cells
American Journal of Physiology-Lung Cellular and Molecular Physiology, 1996The efficacy of preservation fluids on the cytoskeleton and contractile function of porcine pulmonary arterial smooth muscle (SM) cells during cooling and rewarming was evaluated, using EuroCollins solution (EC), University of Wisconsin solution (UW), Marshall's solution (MS), and tissue culture growth medium (GM).
S M, Hall, S G, Haworth
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Paxillin Regulates Pulmonary Arterial Smooth Muscle Cell Function in Pulmonary Hypertension
The American Journal of Pathology, 2012Pulmonary hypertension (PH) is a fatal disease characterized by remodeling processes such as increased migration and proliferation of pulmonary arterial smooth muscle cells (PASMC), enhanced matrix deposition, and dysregulation of cytoskeletal proteins. However, the contribution of cytoskeletal proteins in PH is still not fully understood.
Christine, Veith +6 more
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Antiproliferative effect of sildenafil on human pulmonary artery smooth muscle cells
Basic Research in Cardiology, 2004Pulmonary arterial hypertension (PAH) is characterized by vasoconstriction and by obstructive changes of the pulmonary vasculature including smooth muscle cell proliferation which leads to medial hypertrophy and subsequent luminal narrowing. Sildenafil, an orally active inhibitor of cGMP phosphodiesterase-type-5, exerts pulmonary vasodilator activity ...
TANTINI, BENEDETTA +7 more
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Effects of Trimethoxystilbene on Proliferation and Apoptosis of Pulmonary Artery Smooth Muscle Cells
Cell Biochemistry and Biophysics, 2012Proliferation of pulmonary artery smooth muscle cells (PASMC) is an important contributor to the progress of pulmonary arterial hypertension (PAH). Anti-inflammatory therapies may have therapeutic applicability for PAH. Resveratrol (RES) has prominent anti-inflammatory effects in vitro, but in vivo its beneficial effects are limited by short systemic ...
Ge, Gao +7 more
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Sustained membrane depolarization and pulmonary artery smooth muscle cell proliferation
American Journal of Physiology-Cell Physiology, 2000Pulmonary vasoconstriction and vascular medial hypertrophy greatly contribute to the elevated pulmonary vascular resistance in patients with pulmonary hypertension. A rise in cytosolic free Ca2+([Ca2+]cyt) in pulmonary artery smooth muscle cells (PASMC) triggers vasoconstriction and stimulates cell growth. Membrane potential ( Em) regulates [Ca2+]cytby
O, Platoshyn +8 more
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Regulation of ornithine decarboxylase by hypoxia in pulmonary artery smooth muscle cells
American Journal of Physiology-Lung Cellular and Molecular Physiology, 1996The polyamines are a family of low-molecular-weight organic cations that play essential intracellular regulatory roles in cell growth and differentiation. Elevations in cellular polyamine contents necessary for most physiological and pathological events in the lung appear to be driven by increase de novo synthesis.
K S, Harrod, J W, Olson, M N, Gillespie
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GPCRs as novel targets in pulmonary artery smooth muscle cells in pulmonary arterial hypertension
The FASEB Journal, 2016There is an unmet need for new therapeutics to treat pulmonary arterial hypertension (PAH): currently approved therapy has limited benefit in terms of overall mortality and many such treatments not only reduce vascular resistance in the pulmonary arterial tree but also have side‐effects, including systemic ...
Krishna Sriram +3 more
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Nitric oxide and the pulmonary artery smooth muscle cell.
Seminars in pediatric surgery, 1997Nitric oxide (NO) is produced by the enzyme nitric oxide synthase (NOS), which exists in different isoforms in various tissues. The inducible NOS (iNOS) isoform of the enzyme is expressed in vascular smooth muscle in response to lipopolysaccharide and inflammatory mediators.
A C, Degnim, D K, Nakayama
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