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Ubiquitination‐Related Diagnostic Biomarkers for Diabetic Nephropathy: Insights From Multiomic Analysis, Drug Docking, and Experimental Validation

The FASEB Journal, Volume 40, Issue 14, 31 July 2026.
The Graphical Abstract demonstrates our research approach. Use GEO database to screen differentially expressed genes (DEGs), and weighted gene co expression network analysis (WGCNA) to identify ubiquitination related gene modules. The LASSO logistic regression and support vector machine recursive feature elimination (SVM‐RFE) algorithm is used to ...
Ting Dong, Miao Hu, Haibo Yu, Ling Zhou, Qing Qiao   +4 more
wiley   +1 more source

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Apoptosis of pulmonary microvascular endothelial cells stimulates vascular smooth muscle cell growth

American Journal of Physiology - Lung Cellular and Molecular Physiology, 2006
We have previously hypothesized that the development of severe angioproliferative pulmonary hypertension is associated with not only initial endothelial cell (EC) apoptosis followed by the emergence of apoptosis-resistant proliferating EC but also with proliferation of vascular smooth muscle cells (VSMC).
Seiichiro Sakao, Laimute Taraseviciene-Stewart   +1 more
exaly   +3 more sources

Culture and characterization of pulmonary microvascular endothelial cells

In Vitro Cellular & Developmental Biology - Animal, 1992
Surface proteins were compared in endothelial cells (EC) obtained from bovine peripheral lung, pulmonary artery and vein, and dorsal aorta using sodium dodecyl sulfate (SDS) polyacrylamide gel electrophoresis. Galactose-containing glycoproteins [molecular weight (M(r)) 160-220 and 40 kDa] binding to the Ricinus communis agglutinin (RCA) and peanut ...
P J, Del Vecchio, A, Siflinger-Birnboim, P N, Belloni, L A, Holleran, H, Lum, A B, Malik   +5 more
openaire   +2 more sources

Proproliferative phenotype of pulmonary microvascular endothelial cells

American Journal of Physiology-Lung Cellular and Molecular Physiology, 2007
Endothelial cells perform a number of important functions including release of vasodilators, control of the coagulation cascade, and restriction of solutes and fluid from the extravascular space. Regulation of fluid balance is of particular importance in the microcirculation of the lung where the loss of endothelial barrier function can lead to ...
Victor, Solodushko, Brian, Fouty
openaire   +2 more sources

Transcriptomic Analysis of Pulmonary Microvascular Endothelial Cells with IQGAP1 Knockdown

DNA and Cell Biology, 2020
Pulmonary microvascular endothelium barrier plays a critical role in protecting the pulmonary tissue from inflammatory injury in acute respiratory distress syndrome and acute lung injury (ARDS/ALI). The dysregulation of IQ-GTPase-activating protein 1 (IQGAP1) was an important etiology of endothelium barrier injury.
Shihong, Su, Aihui, Xu, Yang, Chen, Wanzhen, Li, Xiaojun, Zha, Yani, Wang, Gengyun, Sun   +6 more
openaire   +2 more sources

Transcriptomic analysis of human pulmonary microvascular endothelial cells treated with LPS

Cellular Signalling, 2023
Acute respiratory distress syndrome (ARDS) has a rapid onset and progression, which lead to the severity and complexity of the primary disease and significantly increase the fatality rate of patients. Transcriptomics provides some ideas for clarifying the mechanism of ARDS, exploring prevention and treatment targets, and searching for related specific ...
Kaili, Li, Zuotian, Huang, Chang, Liu, Yuanyuan, Xu, Wei, Chen, Lu, Shi, Can, Li, Fawei, Zhou, Fachun, Zhou   +8 more
openaire   +2 more sources

Microparticle Uptake by Pulmonary Microvascular Endothelial Cells

The FASEB Journal, 2017
Microparticles (MPs) are important for the exchange of information between cells. MPs are extracellular vesicles that range in size from 0.1 to 1 μm in diameter. They are constitutively released from many cell types and are thought to play a role in vascular homeostasis.
April K Scruggs, Thomas C Rich, Natalie N Bauer   +2 more
openaire   +1 more source

Penehyclidine effects the angiogenic potential of pulmonary microvascular endothelial cells

Pulmonary Pharmacology & Therapeutics, 2019
The present study sought to determine the pharmacological effects of penehyclidine, an anticholinergic agent, on the angiogenic capacity of pulmonary microvascular endothelial cells (PMVECs). In vitro Matrigel network formation assay, cell proliferation assay, cell-matrix adhesion assay, and wound-healing assay were performed in PMVECs with or without ...
Peilin, Xie, Zhen, Zheng, Lihua, Jiang, Songwei, Wu   +3 more
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Haemostatic Properties of Human Pulmonary and Cerebral Microvascular Endothelial Cells

Thrombosis and Haemostasis, 1997
SummaryLittle is known on the haemostatic profiles of human microvascular endothelial cells (MVEC) from different tissues. In addition it is not known whether MVEC from patients display the same haemostatic pattern as MVEC coming from healthy controls.
G E, Grau, P, de Moerloose, O, Bulla, J, Lou, Z, Lei, G, Reber, N, Mili, B, Ricou, D R, Morel, P M, Suter   +9 more
openaire   +2 more sources

Involvement of PKCδ and PKD in pulmonary microvascular endothelial cell hyperpermeability

American Journal of Physiology-Cell Physiology, 2004
The involvement of PKC, the isoforms of which are categorized into three subtypes: conventional (α, βI, βII, and γ), novel [δ, ϵ, η, and μ (also known as PKD),θ], and atypical (ζ and ι/λ), in the regulation of endothelial monolayer integrity is well documented. However, isoform activity varies among different cell types. Our goal was to reveal isoform-
John H, Tinsley, Nicole R, Teasdale, Sarah Y, Yuan   +2 more
openaire   +2 more sources