Results 121 to 130 of about 169,884 (264)

Blood Immunopathology of Tuberculosis Patients Disrupts Monocyte‐Dependent T‐Cell Activation and Cytokine Expression

open access: yesImmunology, EarlyView.
TB serum selectively disrupts monocyte‐dependent PHA T cell activation and cytokines associated with proliferation while preserving SEB T cell and Pam3/PHA monocyte cytokine responses. ABSTRACT Pulmonary tuberculosis in humans is characterised by features of immunopathology, which influence both antimycobacterial therapy and the long‐term prognosis. In
Joseph F. Arthur   +20 more
wiley   +1 more source

Safety of upadacitinib in atopic dermatitis in randomized clinical trials across 6 years

open access: yesJournal of the European Academy of Dermatology and Venereology, EarlyView.
The current study found no evidence of cumulative increased safety risks with upadacitinib 15 or 30 mg for up to 6 years and over 9000 patient‐years of safety data in adults and adolescents. There were low rates of adjudicated major adverse cardiovascular events, adjudicated thromboembolic events and malignancies. Abstract Background Atopic dermatitis (
Christopher G. Bunick   +13 more
wiley   +1 more source

Excessive Daytime Sleepiness, but Not Insomnia Is Associated With Dyslipidaemia in Patients With Obstructive Sleep Apnoea Participating in ESADA

open access: yesJournal of Sleep Research, EarlyView.
ABSTRACT Excessive daytime sleepiness (EDS) as well as insomnia have been associated with a higher risk for cardiovascular disease in patients with obstructive sleep apnoea (OSA). The link is not fully understood but may involve dyslipidaemia. The aim of the study was to analyse if the EDS and insomnia phenotypes were associated with deranged serum ...
Andras Bikov   +61 more
wiley   +1 more source

Electromyography Frequency Spectrum Is a Better Indicator of Sleep Bruxism Severity Related to Temporomandibular Disorder Pain Than Conventional Masticatory Muscle Activation and Bruxism Time Indices—A Pilot Study

open access: yesJournal of Sleep Research, EarlyView.
ABSTRACT Sleep bruxism (SB) has been reportedly associated with temporomandibular disorder (TMD); however, solid evidence is lacking. Previous studies have primarily used traditional metrics, such as the masticatory muscle activity (MMA) index and bruxism time index (BTI) to investigate the link between SB and TMD.
Minna Pitkänen   +8 more
wiley   +1 more source

Acidic pH Restricts Non‐Tuberculous Mycobacteria Replication

open access: yesMolecular Microbiology, EarlyView.
Different nontuberculous mycobacteria (NTM) species display unique replication profiles in acidic pH in vitro which correlates to their replication within human macrophages. Inhibition of the acidic environments within the macrophage enhances bacterial viability emphasising the role of acidic pH during NTM infections.
Parise K. Lockwood   +3 more
wiley   +1 more source

Differences in pulmonary cavity features among drug-sensitive pulmonary tuberculosis and multidrug/extensively-resistant pulmonary tuberculosis: a multi-national multi-center computed tomography-based study. [PDF]

open access: yesJ Thorac Dis
Tang SN   +33 more
europepmc   +1 more source

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