Results 61 to 70 of about 3,218,405 (297)

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Factors Effecting Phone Brand’s Purchase Decision, Mediated By Purchase Intention

At-Tadbir: Jurnal Ilmiah Manajemen
As the global market continues to change dynamically, smartphone brands industry constantly developing and innoovate new features to fulfill the market demands.
Yandi Suprapto, Wiliana Halim, Eriliana Kesumahati   +2 more
doaj   +1 more source

INSURANCE SERVICE PURCHASE DECISION-MAKING RATIONALE: EXPERT-BASED EVIDENCE FROM LITHUANIA

Ekonomika, 2013
. This paper deals with the examination of the rationale for insurance service purchase decision making with a focus on Lithuania and its possible implications for both Lithuania and other developing insurance markets.
Aurelija Ulbinaitė, Marija Kučinskienė   +1 more
doaj   +1 more source

Does perceived quality mediate the relationship between country of origin image and consumer buying behaviour in Nigerian hypermarkets?

PLoS ONE, 2023
The aim of this study was to examine the relationship between the country of origin image of a product and consumers' purchasing behavior in Nigerian hypermarkets, as well as the mediating role of perceived price in this relationship.
José Moleiro Martins, Shedrack Chinwuba Moguluwa, João Luis Lucas, Chiemelie Benneth Iloka, Mário Nuno Mata   +4 more
doaj   +1 more source

Consumer purchase decision: factors that influence impulsive purchasing

Revista Brasileira de Marketing, 2020
Objective: The aim of this study was to identify whether spending self-control and long-term orientation influence impulsive buying behavior, and also to understand the variables that may cause individuals to decrease impulsivity.Method: A quantitative survey was carried out to gather data regarding how individuals think and what they consider when ...
Lehmann, Thayná Aparecida, Krug, Juliano, Falaster, Christian Daniel   +2 more
openaire   +3 more sources

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Editorial: Addressing the sexually transmitted infections epidemic in the United States: a sociomedical perspective

Frontiers in Public Health, 2023
Christopher Williams, Keith L. Gray, Keith L. Gray, Laura A. Skrip, Laura A. Skrip, Darren L. Whitfield   +5 more
doaj   +1 more source

A multi-attribute model of Japanese consumer's purchase intention for GM foods

Agricultural Economics (AGRICECON), 2010
This study illustrates that consumers' GM food purchase decision is determined by a set of correlated variables. The interrelationship among the GM food purchase decision determinants is examined conceptually and empirically with a multi-attribute model,
Renee B. KIM
doaj   +1 more source

GREEN MARKETING: STRENGTHEN THE BRAND IMAGE AND INCREASE THE CONSUMERS’ PURCHASE DECISION

MIX: Jurnal Ilmiah Manajemen, 2020
This study aims to determine how much influence green marketing toward consumers’ purchase decision mediated by brand image of Ades mineral water in Jabodetabek. The type of research used in this study is descriptive with a quantitative approach.
Genoveva Genoveva, Dian Ridho Samukti
doaj   +1 more source