Results 1 to 10 of about 311,690 (329)

Hybrid Molecules with Purine and Pyrimidine Derivatives for Antitumor Therapy: News, Perspectives, and Future Directions [PDF]

Molecules
Cancer is a leading cause of death globally, claiming millions of lives each year. Despite the availability of numerous anticancer drugs, the need for new treatment options remains essential. Many current therapies come with significant toxicity, lead to
Simona Iacob (Ciobotaru), Claudia-Simona Stefan, Aurel Nechita, Madalina-Nicoleta Matei, Elena-Lacramioara Lisa, Dana Tutunaru, Iuliu Fulga, Ana Fulga, Alina-Georgiana Cristea (Hohota), Oana-Maria Dragostin   +9 more
doaj   +2 more sources

Temozolomide-Derived AIC Is Incorporated into Purine Synthesis in Glioblastoma. [PDF]

Chem Res Toxicol
Sowers ML, Baljinnyam T, Herring JL, Chang-Gu B, Hackfeld LC, Tang H, Hatch S, Valdes P, Zhang K, Sowers LC.   +9 more
europepmc   +3 more sources

Associations between purine metabolites and clinical symptoms in schizophrenia [PDF]

, 2012
Background: The antioxidant defense system, which is known to be dysregulated in schizophrenia, is closely linked to the dynamics of purine pathway. Thus, alterations in the homeostatic balance in the purine pathway may be involved in the pathophysiology
Debra M. Montrose, George G. Dougherty, Jeffrey K. Yao, Joseph McEvoy, Kenji Hashimoto, Matcheri S. Keshavan, Ravinder D. Reddy, Rima Kaddurah-Daouk, Ruth Condray, Wayne R. Matson   +9 more
core   +13 more sources

The major role of Listeria monocytogenes folic acid metabolism during infection is the generation of N-formylmethionine

mBio, 2023
Folic acid and its derivatives (folates) play central roles in one-carbon metabolism, necessary for the synthesis of purines, pyrimidines, and some amino acids.
Ying Feng, Shannon K. Chang, Daniel A. Portnoy   +2 more
doaj   +1 more source

Ferrocenoyl-adenines: substituent effects on regioselective acylation

Beilstein Journal of Organic Chemistry, 2022
A series of N6-substituted adenine–ferrocene conjugates was prepared and the reaction mechanism underlying the synthesis was explored. The SN2-like reaction between ferrocenoyl chloride and adenine anions is a regioselective process in which the product ...
Mateja Toma, Gabrijel Zubčić, Jasmina Lapić, Senka Djaković, Davor Šakić, Valerije Vrček   +5 more
doaj   +1 more source

Assessment of the temporal trend and daily profiles of the dietary purine intake among Chinese residents during 2014 to 2021

Frontiers in Nutrition, 2023
The incidence of hyperuricemia is on the rise in China, primarily due to dietary habits. However, limited data exists regarding dietary purine intake in the country.
Shiwen Li, Xin Liu, Xiwu Jia, Min Fang, Qing Yang, Zhiyong Gong   +5 more
doaj   +1 more source

Structure-Based Design of 2-Aminopurine Derivatives as CDK2 Inhibitors for Triple-Negative Breast Cancer

Frontiers in Pharmacology, 2022
Cyclin-dependent kinase 2 (CDK2) regulates the progression of the cell cycle and is critically associated with tumor growth. Selective CDK2 inhibition provides a potential therapeutic benefit against certain tumors. Purines and related heterocycle (e.g.,
Hanzhi Liang, Yue Zhu, Zhiyuan Zhao, Jintong Du, Xinying Yang, Hao Fang, Xuben Hou   +6 more
doaj   +1 more source

Synthesis and Cytotoxic Activity of the Derivatives of N-(Purin-6-yl)aminopolymethylene Carboxylic Acids and Related Compounds

Molecules, 2023
Testing a number of N-[omega-(purin-6-yl)aminoalkanoyl] derivatives of 7,8-difluoro-3,4-dihydro-3-methyl-2H-[1,4]benzoxazine in a panel of nine tumor cell lines has shown that the studied compounds exhibit high cytotoxic activity, especially against 4T1 ...
Victor P. Krasnov, Olga A. Vozdvizhenskaya, Maria A. Baryshnikova, Alexandra G. Pershina, Vera V. Musiyak, Tatyana V. Matveeva, Kseniya V. Nevskaya, Olga Y. Brikunova, Dmitry A. Gruzdev, Galina L. Levit   +9 more
doaj   +1 more source

Purine and Purine Isostere Derivatives of Ferrocene: An Evaluation of ADME, Antitumor and Electrochemical Properties

Molecules, 2020
Novel purine and purine isosteres containing a ferrocene motif and 4,1-disubstituted (11a−11c, 12a−12c, 13a−13c, 14a−14c, 15a−15c, 16a, 23a−23c, 24a−24c, 25a−25c) and 1,4-disubstituted (34a−34c and 35a−35c) 1,2,3-triazole rings were synthesized. The most
Valentina Rep, Martina Piškor, Helena Šimek, Petra Mišetić, Petra Grbčić, Jasna Padovan, Vesna Gabelica Marković, Dijana Jadreško, Krešimir Pavelić, Sandra Kraljević Pavelić, Silvana Raić-Malić   +10 more
doaj   +1 more source

Structure of purine nucleoside phosphorylase (DeoD) from Bacillus anthracis [PDF]

, 2005
Protein structures from the causative agent of anthrax (Bacillus anthracis) are being determined as part of a structural genomics programme. Amongst initial candidates for crystallographic analysis are enzymes involved in nucleotide biosynthesis, since ...
Blagova, E V, Brannigan, J A, Fogg, M J, Grenha, R, Levdikov, V M, Wilkinson, A.J., Wilson, K S   +6 more
core   +3 more sources