Results 1 to 10 of about 148,463 (294)

An Enterococcus faecalis isolate harboring both aerobic and anaerobic uric acid metabolic pathways alleviates hyperuricemia in mice

Food Science and Human Wellness
Probiotics have been demonstrated to be effective and safe for hyperuricemia (HUA) and gout treatment. Hence, identifying microbes with high uric acid- or purine-metabolizing ability is highly important. Due to the high load of uric acid in chicken feces,
Depeng Li, Xinyue Yang, A La Teng Zhu La, Meihong Zhang, Zhengtian Lü, Yuqing Feng, Dan Liu, Yuming Guo, Yongfei Hu   +8 more
doaj   +1 more source

Synthesis of purines and adenines containing the hexafluoroisopropyl group

Beilstein Journal of Organic Chemistry, 2020
Several new derivatives of adenine, purine, and theophylline containing the (CF3)2CH group connected to a nitrogen atom of the imidazole ring were prepared by the reaction of 2,2,4,4-tetrakis(trifluoromethyl)-1,3-dithietane (1) with the corresponding ...
Viacheslav Petrov, Rebecca J. Dooley, Alexander A. Marchione, Elizabeth L. Diaz, Brittany S. Clem, William Marshall   +5 more
doaj   +1 more source

Synthesis a Number of Triazene Compounds Derived From Purine and Studying their Biological Activity on Pathogenic Bacteria [PDF]

مجلة جامعة الانبار للعلوم الصرفة, 2012
In this research a number of compounds were prepared by coupling dizonium salts with purine bases. The structures of the prepared compounds were identified by ultra violet ,infra red spectra and Elemental (C.H.N) analysis .The biological activity of ...
Ahmed .M. Mohamed, Hameed H.Ali, Yousif. H. Khalaf   +2 more
doaj   +1 more source

Hybrid Molecules with Purine and Pyrimidine Derivatives for Antitumor Therapy: News, Perspectives, and Future Directions

Molecules
Cancer is a leading cause of death globally, claiming millions of lives each year. Despite the availability of numerous anticancer drugs, the need for new treatment options remains essential. Many current therapies come with significant toxicity, lead to
Simona Iacob (Ciobotaru), Claudia-Simona Stefan, Aurel Nechita, Madalina-Nicoleta Matei, Elena-Lacramioara Lisa, Dana Tutunaru, Iuliu Fulga, Ana Fulga, Alina-Georgiana Cristea (Hohota), Oana-Maria Dragostin   +9 more
doaj   +1 more source

Efficient Synthesis of α-Branched Purine-Based Acyclic Nucleosides: Scopes and Limitations of the Method

Molecules, 2020
An efficient route to acylated acyclic nucleosides containing a branched hemiaminal ether moiety is reported via three-component alkylation of N-heterocycle (purine nucleobase) with acetal (cyclic or acyclic, variously branched) and anhydride ...
Jan Frydrych, Lenka Poštová Slavětínská, Martin Dračínský, Zlatko Janeba   +3 more
doaj   +1 more source

Comprehensive measurement of purines in biological samples

Frontiers in Analytical Science
Defects in numerous aspects of purine metabolism are well-recognized causes for human diseases. The applicability of ultra performance liquid chromatography (UPLC) with photodiode array (PDA) detection for analysis of the most abundant biological ...
Rong Fu, Diane J. Sutcliffe, Ashok R. Dinasarapu, Ellen J. Hess, Ellen J. Hess, H. A. Jinnah, H. A. Jinnah   +6 more
doaj   +1 more source

The Key Role of Purine Metabolism in the Folate-Dependent Phenotype of Autism Spectrum Disorders: An In Silico Analysis

Metabolites, 2020
Folate deficiency in the critical developmental period has been repeatedly associated with an increased risk of Autism spectrum disorders (ASD), but the key pathophysiological mechanism has not yet been identified. In this work, we focused on identifying
Jan Geryk, Daniel Krsička, Markéta Vlčková, Markéta Havlovicová, Milan Macek, Radka Kremlíková Pourová   +5 more
doaj   +1 more source

5-Aminoimidazole-4-carboxamide-1-beta-D-ribofuranosyl 5'-Monophosphate (AICAR), a Highly Conserved Purine Intermediate with Multiple Effects

Metabolites, 2012
AICAR (5-Aminoimidazole-4-carboxamide-1-beta-D-ribofuranosyl 5'-monophosphate) is a natural metabolic intermediate of purine biosynthesis that is present in all organisms.
Bertrand Daignan-Fornier, Benoît Pinson
doaj   +1 more source

Parallel purine‐pyrimidine‐purine triplex: experimental evidence for existence [PDF]

FEBS Letters, 1995
Oligonucleotides 5′‐d(CT)5‐L‐d(AG)5‐L‐d(GA)5‐3′ and 5′‐d(GA)5‐L‐d(TC)5‐L‐d(GA)5‐3′ [L = pO(CH2CH2O)3p] were studied by thermal denaturation, chemical modification and binding of fluorescent dyes. Both oligonucleotides are shown to fold back on itself twice forming at pH 7 a sufficiently stable triplex ether with antiparallel‐oriented oligopurine ...
Shchyolkina, Anna K., Borisova, Olga F., Minyat, Elvira E., Timofeev, Edward N., Il'icheva, Irina A., Khomyakova, Elena B., Florentiev, Vladimir L.   +6 more
openaire   +2 more sources

The Safeguarding Microglia: Central Role for P2Y12 Receptors

Frontiers in Pharmacology, 2021
Si-Si Lin, Si-Si Lin, Yong Tang, Yong Tang, Peter Illes, Peter Illes, Peter Illes, Alexei Verkhratsky, Alexei Verkhratsky, Alexei Verkhratsky   +9 more
doaj   +1 more source