Results 1 to 10 of about 18,780 (231)

Recent advances in understanding and managing adenosine deaminase and purine nucleoside phosphorylase deficiencies

Current Opinion in Allergy and Clinical Immunology, 2013
E. Grunebaum, A. Cohen, C. Roifman
semanticscholar   +1 more source

Purine nucleoside phosphorylase deficiency presenting as severe combined immune deficiency

Immunologic research, 2013
R. Somech, A. Lev, G. Grisaru-Soen, S. Shiran, A. Simon, E. Grunebaum   +5 more
semanticscholar   +1 more source

Purine nucleoside phosphorylase: A target for drug design

Medicinal Research Reviews, 1993
openaire   +3 more sources

Immobilized purine nucleoside phosphorylase from Schistosoma mansoni for specific inhibition studies

Analytical and Bioanalytical Chemistry, 2013
M. C. Moraes, C. Cardoso, Q. Cass
semanticscholar   +1 more source

Mycoplasma hyorhinis–Encoded Purine Nucleoside Phosphorylase: Kinetic Properties and Its Effect on the Cytostatic Potential of Purine-Based Anticancer Drugs

Molecular Pharmacology, 2013
J. Vande Voorde, S. Liekens, J. Balzarini   +2 more
semanticscholar   +1 more source

Purine Nucleoside Phosphorylase: Kinetics, Mechanism, and Specificity

Molecular Pharmacology, 1967
openaire   +2 more sources

The purine nucleoside phosphorylase pnp-1 regulates epithelial cell resistance to infection in C. elegans. [PDF]

PLoS Pathogens, 2021
Intestinal epithelial cells are subject to attack by a diverse array of microbes, including intracellular as well as extracellular pathogens. While defense in epithelial cells can be triggered by pattern recognition receptor-mediated detection of microbe-
Eillen Tecle, Crystal B Chhan, Latisha Franklin, Ryan S Underwood, Wendy Hanna-Rose, Emily R Troemel   +5 more
doaj   +3 more sources

Purine nucleoside phosphorylase enables dual metabolic checkpoints that prevent T cell immunodeficiency and TLR7-associated autoimmunity [PDF]

The Journal of Clinical Investigation, 2022
Purine nucleoside phosphorylase (PNP) enables the breakdown and recycling of guanine nucleosides. PNP insufficiency in humans is paradoxically associated with both immunodeficiency and autoimmunity, but the mechanistic basis for these outcomes is ...
Evan R. Abt, Khalid Rashid, Thuc M. Le, Suwen Li, Hailey R. Lee, Vincent Lok, Luyi Li, Amanda L. Creech, Amanda N. Labora, Hanna K. Mandl, Alex K. Lam, Arthur Cho, Valerie Rezek, Nanping Wu, Gabriel Abril-Rodriguez, Ethan W. Rosser, Steven D. Mittelman, Willy Hugo, Thomas Mehrling, Shanta Bantia, Antoni Ribas, Timothy R. Donahue, Gay M. Crooks, Ting-Ting Wu, Caius G. Radu   +24 more
doaj   +3 more sources

Efficient Synthesis of Purine Nucleoside Analogs by a New Trimeric Purine Nucleoside Phosphorylase from Aneurinibacillus migulanus AM007 [PDF]

Molecules, 2019
Purine nucleoside phosphorylases (PNPs) are promising biocatalysts for the synthesis of purine nucleoside analogs. Although a number of PNPs have been reported, the development of highly efficient enzymes for industrial applications is still in high ...
Gaofei Liu, Tiantong Cheng, Jianlin Chu, Sui Li, Bingfang He   +4 more
doaj   +3 more sources

Purine nucleoside phosphorylase inhibition ameliorates age-associated lower urinary tract dysfunctions [PDF]

JCI Insight, 2020
In the aging population, lower urinary tract (LUT) dysfunction is common and often leads to storage and voiding difficulties classified into overlapping symptom syndromes.
Lori A. Birder, Amanda Wolf-Johnston, Alan J. Wein, Fangzhou Cheng, Mara Grove-Sullivan, Anthony J. Kanai, Alan M. Watson, Donna Stoltz, Simon C. Watkins, Anne M. Robertson, Diane Newman, Roger R. Dmochowski, Edwin K. Jackson   +12 more
doaj   +3 more sources