Purine nucleoside phosphorylase as a target for the treatment of interstitial cystitis/bladder pain syndrome with and without Hunner lesions [PDF]
Scientific ReportsChronic visceral pain disorders, such as interstitial cystitis/bladder pain syndrome (IC/BPS), are difficult to treat, and therapies are limited in number and efficacy.
Lori A. Birder +6 more
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Radical Dehalogenation and Purine Nucleoside Phosphorylase E. coli: How Does an Admixture of 2′,3′-Anhydroinosine Hinder 2-fluoro-cordycepin Synthesis [PDF]
Biomolecules, 2021 During the preparative synthesis of 2-fluorocordycepin from 2-fluoroadenosine and 3′-deoxyinosine catalyzed by E. coli purine nucleoside phosphorylase, a slowdown of the reaction and decrease of yield down to 5% were encountered.
Alexey L. Kayushin +12 more
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Crystallographic snapshots of ligand binding to hexameric purine nucleoside phosphorylase and kinetic studies give insight into the mechanism of catalysis. [PDF]
Sci Rep, 2018 Purine nucleoside phosphorylase (PNP) catalyses the cleavage of the glycosidic bond of purine nucleosides using phosphate instead of water as a second substrate.
Štefanić Z +5 more
europepmc +2 more sources
Use of E. coli Purine Nucleoside Phosphorylase in the Treatment of Solid Tumors. [PDF]
Curr Pharm Des, 2017 BACKGROUND The selective expression of non-human genes in tumor tissue to activate non-toxic compounds (Gene Directed Prodrug Enzyme Therapy, GDEPT) is a novel strategy designed for killing tumor cells in patients with little or no systemic toxicity ...
Parker WB, Sorscher EJ.
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Propolis Exerts an Anti-Inflammatory Effect on PMA-Differentiated THP-1 Cells via Inhibition of Purine Nucleoside Phosphorylase. [PDF]
Metabolites, 2019 Previous research has shown that propolis has immunomodulatory activity. Propolis extracts from different geographic origins were assessed for their anti-inflammatory activities by investigating their ability to alter the production of tumour necrosis ...
Alqarni AM +6 more
europepmc +2 more sources
Conservation of structure and activity in Plasmodium purine nucleoside phosphorylases [PDF]
BMC Structural Biology, 2009 Background Purine nucleoside phosphorylase (PNP) is central to purine salvage mechanisms in Plasmodium parasites, the causative agents of malaria. Most human malaria results from infection either by Plasmodium falciparum (Pf), the deadliest form of the ...
Brady, R Leo, Chaikuad, Apirat
core +8 more sources
Catalytic-site design for inverse heavy-enzyme isotope effects in human purine nucleoside phosphorylase. [PDF]
Proc Natl Acad Sci U S A, 2017 Significance Protein design from first principles is developing rapidly for structural elements, binding domains, and protein–protein interactions. Design of structural elements to generate predictable changes in the fundamental properties of enzymatic ...
Harijan RK +4 more
europepmc +2 more sources
Purine nucleoside phosphorylase deficiency
Atlas of Inherited Metabolic Diseases, 2020 People with purine nucleoside phosphorylase deficiency have low numbers of immune system cells called T cells, which normally recognize and attack foreign invaders to prevent infection.
C. Staufner
semanticscholar +2 more sources
Purine Nucleoside Phosphorylase as a Cytosolic Arsenate Reductase [PDF]
Toxicological Sciences, 2002 The findings of the accompanying paper (Németi and Gregus, Toxicol: Sci. 70, 4-12) indicate that the arsenate (AsV) reductase activity of rat liver cytosol is due to an SH enzyme that uses phosphate (or its analogue, arsenate, AsV) and a purine nucleoside (guanosine or inosine) as substrates. Purine nucleoside phosphorylase (PNP) is such an enzyme.
Zoltán Gregus
openalex +4 more sources
Immunodeficiency, motor delay, and hypouricemia caused by a novel mutation of purine nucleoside phosphorylase gene in an Indian infant [PDF]
Annals of Indian Academy of Neurology, 2019 We describe an 11-month-old boy who presented with recurrent respiratory infections from 6 months of age. His elder sister died at 10 months with severe septicemia and meningitis. The boy had a mild motor delay.
Nikit Shah +5 more
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