Nicotinamide riboside-amino acid conjugates that are stable to purine nucleoside phosphorylase. [PDF]
Org Biomol Chem, 2020 Hayat F, Migaud ME.
europepmc +3 more sources
Journal of Advanced Biotechnology and Experimental Therapeutics, 2023 Purine Nucleoside Phosphorylase (PNP) is an enzyme involved in biosynthetic pathway of purine nucleosides. Purine nucleoside phosphorylase catalyzes the cleavage of the glycosidic bond of ribo- or deoxyribonucleosides to form the purine base and ...
Jaloliddin Abdurakhmanov +12 more
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Molecules, 2023 To explore the anti-hyperuricemia components in sunflower (Helianthus annuus L.) calathide extract (SCE), we identified abietic acid (AA) via liquid chromatography–mass spectrometry and found an excellent inhibitor of xanthine oxidase (IC50 = 10.60 µM ...
Huining Dai +5 more
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Structural determinants of the 5'-methylthioinosine specificity of Plasmodium purine nucleoside phosphorylase. [PDF]
PLoS ONE, 2014 Plasmodium parasites rely upon purine salvage for survival. Plasmodium purine nucleoside phosphorylase is part of the streamlined Plasmodium purine salvage pathway that leads to the phosphorylysis of both purines and 5'-methylthiopurines, byproducts of ...
Teraya M Donaldson +6 more
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Efficient Biocatalytic Synthesis of Dihalogenated Purine Nucleoside Analogues Applying Thermodynamic Calculations [PDF]
, 2020 The enzymatic synthesis of nucleoside analogues has been shown to be a sustainable and efficient alternative to chemical synthesis routes. In this study, dihalogenated nucleoside analogues were produced by thermostable nucleoside phosphorylases in ...
Giessmann, Robert T. +9 more
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Thermodynamic reaction control of nucleoside phosphorolysis [PDF]
, 2020 Nucleoside analogs represent a class of important drugs for cancer and antiviral treatments. Nucleoside phosphorylases (NPases) catalyze the phosphorolysis of nucleosides and are widely employed for the synthesis of pentose‐1‐phosphates and nucleoside ...
Giessmann, Robert T. +4 more
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PNP inhibitors selectively kill cancer cells lacking SAMHD1
Molecular & Cellular Oncology, 2020 Purine nucleoside phosphorylase inhibitors (PNP-Is) were developed to ablate transformed lymphocytes. However, only some patients with leukemia benefit from PNP-Is. We provide a molecular explanation: the deoxyribonucleoside triphosphate (dNTP) hydrolase
Tamara Davenne, Jan Rehwinkel
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An Enzymatic Flow-Based Preparative Route to Vidarabine
Molecules, 2020 The bi-enzymatic synthesis of the antiviral drug vidarabine (arabinosyladenine, ara-A), catalyzed by uridine phosphorylase from Clostridium perfringens (CpUP) and a purine nucleoside phosphorylase from Aeromonas hydrophila (AhPNP), was re-designed under ...
Lucia Tamborini +10 more
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Functional and Structural Characterization of Purine Nucleoside Phosphorylase from Kluyveromyces lactis and Its Potential Applications in Reducing Purine Content in Food. [PDF]
PLoS ONE, 2016 Consumption of foods and beverages with high purine content increases the risk of hyperuricemia, which causes gout and can lead to cardiovascular, renal, and other metabolic disorders.
Durga Mahor +3 more
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Purine nucleoside phosphorylase: A new marker for free oxygen radical injury to the endothelial cell [PDF]
, 1990 The effect of ischemia and reperfusion on purine nucleoside phosphorylase was studied in an isolated perfused rat liver model. This enzyme is localized primarily in the cytoplasm of the endothelial and Kupffer cells; some activity is associated with the ...
Abouna +32 more
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