Results 111 to 120 of about 124,162 (316)

Harnessing molecular recognition for small molecule‐mediated, reversible photochemical control over mRNA translation

Angewandte Chemie International Edition, Accepted Article.
Chemical probes that control the function of complex RNA molecules offer unique opportunities to interrogate biological systems. In this study, we demonstrate that a small molecule ligand selectively recognizes and undergoes traceless, reversible photocrosslinking to PreQ1 RNA aptamers.
Shaifaly Parmar, Logan Tenney, Xiao Liang, John T. Routzahn, Christopher D. Sibley, John Schneekloth   +5 more
wiley   +1 more source

Heterocyclic Nitrogen Compounds as Potential PDE4B Inhibitors in Activated Macrophages

Applied Sciences
Cyclic-nucleotide phosphodiesterases (PDEs) represent a superfamily of enzymes playing a pivotal role in cell signaling by controlling cAMP and cGMP levels in response to receptor activation.
Simona Todisco, Vittoria Infantino, Anna Caruso, Anna Santarsiero, Paolo Convertini, Hussein El-Kashef, Federica Giuzio, Maria Stefania Sinicropi, Carmela Saturnino   +8 more
doaj   +1 more source

Purine and pyrimidine nucleotide metabolism in Mollicutes

Genetics and Molecular Biology, 2007
Several mollicute genome projects are underway, offering unique opportunities to study genes and metabolic pathways on a genome-wide scale. Here, we have analyzed the conservation and diversity of purine and pyrimidine metabolism in mycoplasmas.
Cristiano Valim Bizarro, Desirée Cigaran Schuck   +1 more
doaj   +1 more source

PURINE SYNTHESIS IN SUSPENSIONS OF MUCOSA FROM THE SMALL INTESTINE OF THE RAT [PDF]

, 1958
A. R. P. Paterson, S. H. Zbarsky
openalex   +1 more source

Histochemical indications for a chemically complex signal produced by the cervical gill slit gland of the pygmy sperm whale (Kogia breviceps)

The Anatomical Record, EarlyView.
Abstract The pygmy sperm whale (Kogia breviceps) possesses an exocrine gland associated with its false gill slit pigmentation pattern. The cervical gill slit gland is a compound tubuloalveolar gland that produces a holocrine secretion and displays maturational changes in size and secretory histology. While the morphology of the cervical gill slit gland
Tiffany F. Keenan, William A. McLellan, Sentiel A. Rommel, Alexander M. Costidis, Craig A. Harms, J. G. M. Thewissen, Susan J. Rehorek, David S. Rotstein, Mark D. Gay, Alison R. Taylor, Heather N. Koopman, Ying Wang, Stephanie Kamel, D. Ann Pabst   +13 more
wiley   +1 more source

Probiotics in Alleviating Hyperuricemia: Research Status, Mechanism of Action and Challenges

Shipin gongye ke-ji
Hyperuricemia (HUA) is a chronic metabolic disease, characterized by excessive uric acid in the blood, caused by purine metabolism disorders. Studies show that conventional clinical treatment methods have certain limitations, while probiotics have the ...
Xinru YANG, Jiayue TANG, Xiaoqun ZENG, Zhen WU, Qiwei DU, Maolin TU   +5 more
doaj   +1 more source

Characterization of the pattern of development of key compounds contributing to aroma quality of chicken meat and their metabolic markers

Animal Research and One Health, EarlyView.
The graphical abstract shows the principal results of this study. Eight major aroma‐contributing compounds (nonanal, octanal, dimethyl tetrasulfide, hexanal, 1‐octen‐3‐ol, (E)‐2‐nonenal, heptanal, and (E,E)‐2,4‐decadienal) were identified by electronic nose and GC‐O‐MS analysis, and their content increased with age.
Yanke Wang, Xiaojing Liu, Yongli Wang, Zhengxiao He, Guiping Zhao, Jie Wen, Huanxian Cui   +6 more
wiley   +1 more source

Probiotics administration alleviates cognitive impairment and circadian rhythm disturbance induced by sleep deprivation

Food Science and Human Wellness
Gut microbiome is indispensable for maintaining normal brain function. Specifically, gut microbiota plays a causal role in sleep deprivation (SD)-induced cognitive impairment.
Peijun Tian, Yunfei Hou, Zheng Wang, Jiaona Jiang, Xin Qian, Zhihao Qu, Jianxin Zhao, Gang Wang, Wei Chen   +8 more
doaj   +1 more source

The Genetic Code Boolean Lattice [PDF]

Published in MATCH Commun. Math. Comput. Chem 52, 29-46. (2004), 2004
The algebraic structures of the genetic code are most important to obtain additional information about the semantic code and its applications. In this paper we define two dual Boolean codon lattices of the genetic code using hydrogen bond numbers and the chemical types of bases: purines and pyrimidines.
arxiv  

Severe myelosuppression and alopecia after thiopurine initiation in a patient with NUDT15 deficiency

British Journal of Clinical Pharmacology, EarlyView.
Thiopurines are a class of immunosuppressant and antineoplastic agents. They are widely used in the treatment of inflammatory bowel disease, haematological malignancies and autoimmune diseases, but can cause significant toxicity. Inherited gene mutations are now recognized as independent risk factors for severe adverse drug reactions to thiopurines ...
Annie Siyu Wu, Lee Mozessohn, Richard B. Kim, Jonathan S. Zipursky   +3 more
wiley   +1 more source