Results 131 to 140 of about 124,162 (316)

FLOT1 Is a Novel Serum Biomarker of Ovarian Cancer Targeted by N6‐methyladenosine Modification Inhibition

Cell Biology International, EarlyView.
ABSTRACT Ovarian cancer (OC) is a deadly disease and lacks a precise marker for diagnosis worldwide. Our previous work has shown the overexpression of flotillin‐1 (FLOT1) in OC tissue. To improve diagnostic sensitivity and accuracy, we evaluated the serum level of FLOT1 in OC patients and found that the serum concentration of FLOT1 as well as CA125 was
Bin Guan, Qi Lu, Junyu Chen, Jingyi Fang, Zhenyu Liu, Wei Li, Lingyun Zhang, Guoxiong Xu   +7 more
wiley   +1 more source

BIOSYNTHESIS OF THE PURINES

, 1957
Leonard Warren, John M. Buchanan
openalex   +2 more sources

Synthesis, Antiproliferative Activity, and ADME Profiling of Novel Racemic and Optically Pure Aryl-Substituted Purines and Purine Bioisosteres

Biomolecules
The aim of this study was to synthesize new racemic and optically pure aryl-substituted purine bioisosteres using ultrasound-assisted Cu(I)-catalyzed Huisgen 1,3-dipolar cycloaddition.
Martina Piškor, Astrid Milić, Sanja Koštrun, Maja Majerić Elenkov, Petra Grbčić, Sandra Kraljević Pavelić, Krešimir Pavelić, Silvana Raić-Malić   +7 more
doaj   +1 more source

Contemporary Perspectives on Chronic Renal Disorders

Chronic Diseases and Translational Medicine, EarlyView.
ABSTRACT The prevalence of renal diseases and its associated burden on healthcare have tremendously risen in the past few years. From simple markers assessing kidney function, current renal research delves into understanding the diseases at the cellular and molecular levels and not just at treating, but at improving quality of life, arresting ...
Deenadhayalan Ashok, Poornima Ajay Manjrekar, Bhushan C. Shetty, Sujina S. S, Rukmini Mysore Srikantiah, Sowndarya Kollampare   +5 more
wiley   +1 more source

RESEARCHES ON PURINES

, 1913
Carl O. Johns
openalex   +2 more sources

A proteome‐scale analysis of vertebrate protein amino acid occurrence: Thermoadaptation shows a correlation with protein solvation but less so with dynamics

Proteins: Structure, Function, and Bioinformatics, Volume 91, Issue 1, Page 3-15, January 2023., 2023
Abstract Despite differences in behaviors and living conditions, vertebrate organisms share the great majority of proteins, often with subtle differences in amino acid sequence. Here, we present a simple way to analyze the difference in amino acid occurrence by comparing highly homologous proteins on a subproteome level between several vertebrate model
Zhen‐Lu Li, Matthias Buck
wiley   +1 more source

A Cytotoxic Indazole‐based Gold(III) Carboxamide Pincer Complex Targeting DNA Through Dual Binding Modes of Groove Binding and Alkylation

Chemistry – A European Journal, EarlyView.
Toward new gold(III) anticancer agents. Herein, we report on an indazole‐based gold(III) carboxamide pincer complex exhibiting significant cytotoxicity, likely mediated through dual interactions with DNA. Mechanistic investigations suggest that the complex binds to the DNA and forms specific interactions with nucleotide bases.
Rufaro Razuwika, Sheldon Sookai, Ruth Aronson, Mandeep Kaur, Orde Q. Munro   +4 more
wiley   +1 more source

Design and Evaluation of Bivalent K‐Ras Inhibitors that Target the CAAX Binding Site and the Acidic Surface of Farnesyltransferase and Geranylgeranyltransferase I

Chemistry – A European Journal, Accepted Article.
Mutant K‐Ras drives cancer through its membrane localization, which requires post‐translational modification by farnesyltransferase (FTase). FTase attaches farnesyl to the K‐Ras C‐terminal CVIM tetrapeptide, enabling membrane binding. However, K‐Ras can also undergo compensatory geranylgeranylation by geranylgeranyltransferase I (GGTase I), making ...
Junko Ohkanda, Naomi Horiuchi, Rania Omer, Fumitoshi Sugino, Naomi Ogino, Yoshihisa Inoue, Kazi Aslamuzzaman, Takeyuki Suzuki, Said Sebti   +8 more
wiley   +1 more source

A Robust Strategy for Introducing Amino‐Modifiers in Nucleic Acids: Enabling Novel Amino Tandem Oligonucleotide Synthesis in DNA and RNA

Chemistry – A European Journal, EarlyView.
We report a simple, efficient, and cost‐effective methodology for introducing amino‐modifiers into DNA and RNA using a commercially available solid support. By incorporating a base‐labile sulfonyl linker within the strand, we developed an amino‐containing tandem oligonucleotide synthesis (aTOS) methodology, which enables the introduction of multiple ...
Jagandeep S. Saraya, Nicholas G. Horton, Scott R. Sammons, Derek K. O′Flaherty   +3 more
wiley   +1 more source

CAQ Corner: Basic concepts of transplant immunology

, 2022
Liver Transplantation, EarlyView.
Amanda Cheung, Josh Levitsky
wiley   +1 more source