Results 171 to 180 of about 151,646 (288)

Harnessing energy metabolism for enhanced bone defect repair: Mechanisms and therapeutic strategies

VIEW, EarlyView.
This review addresses the critical challenge of bone defect repair by focusing on the underexplored role of cellular energy metabolism. It synthesizes regulatory mechanisms in bone‐forming cells and sums up innovative strategies—leveraging cell derivatives, active factors, and biomimetic scaffolds—to modulate metabolism for enhanced regeneration.
Junting Li, Yulan Liu, Yuran Li, Yingjie Hua, Xinquan Jiang, Mingliang Zhou   +5 more
wiley   +1 more source

ppAT drives glutamine-dependent purine biosynthesis and malignant progression in hepatocellular carcinoma. [PDF]

BMC Cancer
Zhou J, Dong C, Xu S, Wang J, Ye H, Fan X, Li S, Wang S.   +7 more
europepmc   +1 more source

Below‐ground drivers of rhizosphere functional gene assembly during Moso bamboo expansion

Functional Ecology, EarlyView.
Read the free Plain Language Summary for this article on the Journal blog. Abstract Moso bamboo (Phyllostachys edulis) expansion threatens subtropical forest biodiversity, yet how intraspecific root trait variation shapes rhizosphere microbial functional potential remains unclear.
Yaoxing Wu, Zhiying Tang, Jiahuan Guo, Lizheng Fang, Huilin Shu, Lin Yu, Gong Zhang, Jun Deng, Lianghua Qi   +8 more
wiley   +1 more source

Design and Synthesis of Novel Purine Analogues as Potential IL-1β Inhibitors Targeting Vascular Inflammation. [PDF]

Chem Biodivers
Pournara DT, Fotopoulou T, Paramel G, Lindkvist M, Grenegård M, Fransén K, Koufaki M.   +6 more
europepmc   +1 more source

Congenital CMV Infection: Determination of Transplacental Passage of Aciclovir by Ex Vivo Placental Perfusion

BJOG: An International Journal of Obstetrics &Gynaecology, EarlyView.
ABSTRACT Objective To quantify the transplacental transfer of aciclovir at an amount equivalent to 2 g of valaciclovir corresponding to the fractionated dosing regimen given four times daily used to reduce congenital cytomegalovirus (CMV) transmission and to treat the CMV‐infected fetus. Design Experimental ex vivo study.
Helyett Ollivier, Valentine Faure Bardon, Leo Froelicher Bournaud, Isidore Gaubert, Tiffany Guilleminot, Marianne Leruez‐Ville, Jean‐Marc Treluyer, Yves Ville, Gabrielle Lui, Julien Stirnemann   +9 more
wiley   +1 more source

Metabolic and neurobehavioral disturbances induced by purine recycling deficiency in Drosophila

Céline Petitgas, Laurent Seugnet, Amina Dulac, Giorgio Matassi, Ali Mteyrek, Rebecca Fima, Marion Strehaiano, Joana Dagorret, Baya Chérif‐Zahar, Sandrine Marie, Irène Ceballos-Picot, Serge Birman   +11 more
openalex   +1 more source

Electrostatic and Hydrophobic Interactions Mediate Single‐Stranded DNA Recognition and Acta2 Repression by Purine‐Rich Element Binding Protein B

, 2016
Lauren Ferris, Amy E. Rumora, Tamar Wheeler, Robert J. Kelm   +3 more
openalex   +2 more sources

Lactobacillus paragasseri LG-1 Alleviates Urticaria-Like Symptoms in Mice via Modulation of Gut Microbiota, Hypoxanthine and Uric Acid. [PDF]

Microb Biotechnol
Wang Q, Hu Z, Wang Y, Guo S, Zhang X, Ren Y, Li J, Li X, Cui H.   +8 more
europepmc   +1 more source

Molecular characterization of transformer, transformer‐2, and doublesex genes in the carambola fruit fly, Bactrocera carambolae, revealing potential for genetic pest management

Insect Science, EarlyView.
Abstract Globalization and climate change may be driving the spread of the quarantine fruit fly, Bactrocera carambolae, highlighting the need for ecofriendly control methods like the Sterile Insect Technique (SIT), which relies on releasing sterile males to reduce wild populations.
Kamoltip Laohakieat, Thanalai Poonsiri, Nidchaya Aketarawong   +2 more
wiley   +1 more source

DIPG-17. DYSREGULATED PURINE METABOLISM IN A LETHAL CHILDHOOD BRAINSTEM TUMOR REVEALS NEW TREATMENT STRATEGIES WITH OLD DRUGS [PDF]

Ian Mersich, Sunny Congrove, Matthew J. Horchar, Román Cáceres, Janki Desai, Pankaj B. Desai, Larry Sallans, Julie Haines, Ranjith Menon, Charles B. Stevenson, Peter de Blank, Natasha Pillay‐Smiley, Trent R. Hummel, Ali Tavassoli, Angelo D’Alessandro, Timothy N. Phoenix, Biplab Dasgupta   +16 more
openalex   +1 more source