Results 11 to 20 of about 148,463 (294)

Purine-Furan and Purine-Thiophene Conjugates [PDF]

Molbank, 2018
Furyl and thienyl moieties were introduced into a purine structure to elevate its fluorescence properties, while a trityl group was used to increase the amorphous properties of the purine compounds.
Zigfrīds Kapilinskis, Irina Novosjolova, Māris Turks   +2 more
doaj   +2 more sources

Protonated pyrimidine-purine-purine triplex [PDF]

Nucleic Acids Research, 1993
We have studied a protonated pyrimidine-purine-purine (Py-Pu-Pu) triplex, which is formed between the d(C)nd(G)n duplex and the d(AG)m oligonucleotide as the third strand and carries the CG*A+ protonated base-triads. We have observed such an intermolecular complex between a plasmid carrying the d(C)18 d(G)18 insert and the d(AG)5 oligonucleotide ...
V A, Malkov, O N, Voloshin, A G, Veselkov, V M, Rostapshov, I, Jansen, V N, Soyfer, M D, Frank-Kamenetskii   +6 more
openaire   +2 more sources

The major role of Listeria monocytogenes folic acid metabolism during infection is the generation of N-formylmethionine

mBio, 2023
Folic acid and its derivatives (folates) play central roles in one-carbon metabolism, necessary for the synthesis of purines, pyrimidines, and some amino acids.
Ying Feng, Shannon K. Chang, Daniel A. Portnoy   +2 more
doaj   +1 more source

Ferrocenoyl-adenines: substituent effects on regioselective acylation

Beilstein Journal of Organic Chemistry, 2022
A series of N6-substituted adenine–ferrocene conjugates was prepared and the reaction mechanism underlying the synthesis was explored. The SN2-like reaction between ferrocenoyl chloride and adenine anions is a regioselective process in which the product ...
Mateja Toma, Gabrijel Zubčić, Jasmina Lapić, Senka Djaković, Davor Šakić, Valerije Vrček   +5 more
doaj   +1 more source

Assessment of the temporal trend and daily profiles of the dietary purine intake among Chinese residents during 2014 to 2021

Frontiers in Nutrition, 2023
The incidence of hyperuricemia is on the rise in China, primarily due to dietary habits. However, limited data exists regarding dietary purine intake in the country.
Shiwen Li, Xin Liu, Xiwu Jia, Min Fang, Qing Yang, Zhiyong Gong   +5 more
doaj   +1 more source

Structure-Based Design of 2-Aminopurine Derivatives as CDK2 Inhibitors for Triple-Negative Breast Cancer

Frontiers in Pharmacology, 2022
Cyclin-dependent kinase 2 (CDK2) regulates the progression of the cell cycle and is critically associated with tumor growth. Selective CDK2 inhibition provides a potential therapeutic benefit against certain tumors. Purines and related heterocycle (e.g.,
Hanzhi Liang, Yue Zhu, Zhiyuan Zhao, Jintong Du, Xinying Yang, Hao Fang, Xuben Hou   +6 more
doaj   +1 more source

Synthesis and Cytotoxic Activity of the Derivatives of N-(Purin-6-yl)aminopolymethylene Carboxylic Acids and Related Compounds

Molecules, 2023
Testing a number of N-[omega-(purin-6-yl)aminoalkanoyl] derivatives of 7,8-difluoro-3,4-dihydro-3-methyl-2H-[1,4]benzoxazine in a panel of nine tumor cell lines has shown that the studied compounds exhibit high cytotoxic activity, especially against 4T1 ...
Victor P. Krasnov, Olga A. Vozdvizhenskaya, Maria A. Baryshnikova, Alexandra G. Pershina, Vera V. Musiyak, Tatyana V. Matveeva, Kseniya V. Nevskaya, Olga Y. Brikunova, Dmitry A. Gruzdev, Galina L. Levit   +9 more
doaj   +1 more source

Purine and Purine Isostere Derivatives of Ferrocene: An Evaluation of ADME, Antitumor and Electrochemical Properties

Molecules, 2020
Novel purine and purine isosteres containing a ferrocene motif and 4,1-disubstituted (11a−11c, 12a−12c, 13a−13c, 14a−14c, 15a−15c, 16a, 23a−23c, 24a−24c, 25a−25c) and 1,4-disubstituted (34a−34c and 35a−35c) 1,2,3-triazole rings were synthesized. The most
Valentina Rep, Martina Piškor, Helena Šimek, Petra Mišetić, Petra Grbčić, Jasna Padovan, Vesna Gabelica Marković, Dijana Jadreško, Krešimir Pavelić, Sandra Kraljević Pavelić, Silvana Raić-Malić   +10 more
doaj   +1 more source

Synthesis, Acidity Constants and Tautomeric Structure of the Diazonium Coupling Products of 2-(Benzylsulfanyl)-7H-purin-6-one in Its Ground and Excited States

Molecules, 2011
A series of new 8-arylhydrazono-2-(benzylsulfanyl)-7H-purin-6-ones 6 were synthesized, their electronic absorption spectra in different organic solvents of varying polarities were investigated and their acid dissociation constants in both the ground and ...
Hosam A. Saad, Farag M. Altalbawy, Elham S. Darwish, Mosselhi A. Mosselhi   +3 more
doaj   +1 more source

Influência do nitrogênio degradável no rúmen sobre a degradabilidade in situ, os parâmetros ruminais e a eficiência de síntese microbiana em novilhos alimentados com cana-de-açúcar Ruminal degradable nitrogen for steers fed sugar cane: in situ degradability, ruminal parameters and microbial synthesis efficiency

Revista Brasileira de Zootecnia, 2009
Objetivou-se avaliar o efeito da deficiência de nitrogênio degradável no rúmen (NDR), utilizando como volumoso cana-de-açúcar suplementada com uréia, farelo de soja ou farelo de glúten de milho - 60, sobre a eficiência de síntese microbiana e a ...
Roselene Nunes da Silveira, Telma Teresinha Berchielli, Roberta Carrilho Canesin, Juliana Duarte Messana, Juliano José de Resende Fernandes, Alexandre Vaz Pires   +5 more
doaj   +1 more source