Results 11 to 20 of about 209,598 (340)

Potential Mechanisms Connecting Purine Metabolism and Cancer Therapy

Frontiers in Immunology, 2018
Unrestricted cell proliferation is a hallmark of cancer. Purines are basic components of nucleotides in cell proliferation, thus impaired purine metabolism is associated with the progression of cancer.
Jie Yin, Jie Yin, Jie Yin, Wenkai Ren, Xingguo Huang, Xingguo Huang, Jinping Deng, Tiejun Li, Yulong Yin, Yulong Yin   +9 more
doaj   +2 more sources

Comprehensive measurement of purines in biological samples [PDF]

Frontiers in Analytical Science
Defects in numerous aspects of purine metabolism are well-recognized causes for human diseases. The applicability of ultra performance liquid chromatography (UPLC) with photodiode array (PDA) detection for analysis of the most abundant biological ...
Rong Fu, Diane J. Sutcliffe, Ashok R. Dinasarapu, Ellen J. Hess, Ellen J. Hess, H. A. Jinnah, H. A. Jinnah   +6 more
doaj   +2 more sources

Purine-Furan and Purine-Thiophene Conjugates [PDF]

Molbank, 2018
Furyl and thienyl moieties were introduced into a purine structure to elevate its fluorescence properties, while a trityl group was used to increase the amorphous properties of the purine compounds.
Zigfrīds Kapilinskis, Irina Novosjolova, Māris Turks   +2 more
doaj   +2 more sources

Purine Metabolism Dysfunctions: Experimental Methods of Detection and Diagnostic Potential

International Journal of Molecular Sciences, 2023
Purines, such as adenine and guanine, perform several important functions in the cell. They are found in nucleic acids; are structural components of some coenzymes, including NADH and coenzyme A; and have a crucial role in the modulation of energy ...
A. Cicero, F. Fogacci, Valentina Di Micoli, C. Angeloni, M. Giovannini, C. Borghi   +5 more
semanticscholar   +1 more source

Protonated pyrimidine-purine-purine triplex [PDF]

Nucleic Acids Research, 1993
We have studied a protonated pyrimidine-purine-purine (Py-Pu-Pu) triplex, which is formed between the d(C)nd(G)n duplex and the d(AG)m oligonucleotide as the third strand and carries the CG*A+ protonated base-triads. We have observed such an intermolecular complex between a plasmid carrying the d(C)18 d(G)18 insert and the d(AG)5 oligonucleotide ...
V A, Malkov, O N, Voloshin, A G, Veselkov, V M, Rostapshov, I, Jansen, V N, Soyfer, M D, Frank-Kamenetskii   +6 more
openaire   +2 more sources

Targeting purine metabolism in ovarian cancer

Journal of Ovarian Research, 2022
Purine, an abundant substrate in organisms, is a critical raw material for cell proliferation and an important factor for immune regulation. The purine de novo pathway and salvage pathway are tightly regulated by multiple enzymes, and dysfunction in ...
Jingchun Liu, Sha-sha Hong, Jiang Yang, Xiaoyi Zhang, Ying Wang, Haoyu Wang, Jiaxin Peng, L. Hong   +7 more
semanticscholar   +1 more source

Purine nucleotide depletion prompts cell migration by stimulating the serine synthesis pathway

Nature Communications, 2022
Purine nucleotides are necessary for various biological processes related to cell proliferation. Despite their importance in DNA and RNA synthesis, cellular signaling, and energy-dependent reactions, the impact of changes in cellular purine levels on ...
Mona H Soflaee, R. Kesavan, Umakant Sahu, Alpaslan Tasdogan, Elodie Villa, Zied Djabari, Feng Cai, Diem H. Tran, Hieu S Vu, Eunus S. Ali, Halie Rion, Brendan P. O’Hara, Sherwin Kelekar, James Hughes Hallett, Misty Martin, Thomas P. Mathews, Peng Gao, John M. Asara, Brendan D. Manning, I. Ben-Sahra, G. Hoxhaj   +20 more
semanticscholar   +1 more source

The major role of Listeria monocytogenes folic acid metabolism during infection is the generation of N-formylmethionine

mBio, 2023
Folic acid and its derivatives (folates) play central roles in one-carbon metabolism, necessary for the synthesis of purines, pyrimidines, and some amino acids.
Ying Feng, Shannon K. Chang, Daniel A. Portnoy   +2 more
doaj   +1 more source

Ferrocenoyl-adenines: substituent effects on regioselective acylation

Beilstein Journal of Organic Chemistry, 2022
A series of N6-substituted adenine–ferrocene conjugates was prepared and the reaction mechanism underlying the synthesis was explored. The SN2-like reaction between ferrocenoyl chloride and adenine anions is a regioselective process in which the product ...
Mateja Toma, Gabrijel Zubčić, Jasmina Lapić, Senka Djaković, Davor Šakić, Valerije Vrček   +5 more
doaj   +1 more source

Evolutionary impacts of purine metabolism genes on mammalian oxidative stress adaptation

Zoological Research, 2022
Many mammals risk damage from oxidative stress stemming from frequent dives (i.e., cycles of ischemia/reperfusion and hypoxia/reoxygenation), high altitude and subterranean environments, or powered flight.
Ran Tian, Chenju Yang, Simin Chai, Han Guo, I. Seim, Guang Yang   +5 more
semanticscholar   +1 more source