Results 11 to 20 of about 186,546 (339)
Potential Mechanisms Connecting Purine Metabolism and Cancer Therapy
Frontiers in Immunology, 2018 Unrestricted cell proliferation is a hallmark of cancer. Purines are basic components of nucleotides in cell proliferation, thus impaired purine metabolism is associated with the progression of cancer.
Jie Yin +9 more
doaj +2 more sources
Purine Metabolism Dysfunctions: Experimental Methods of Detection and Diagnostic Potential
International Journal of Molecular Sciences, 2023 Purines, such as adenine and guanine, perform several important functions in the cell. They are found in nucleic acids; are structural components of some coenzymes, including NADH and coenzyme A; and have a crucial role in the modulation of energy ...
A. Cicero +5 more
semanticscholar +1 more source
Targeting purine metabolism in ovarian cancer
Journal of Ovarian Research, 2022 Purine, an abundant substrate in organisms, is a critical raw material for cell proliferation and an important factor for immune regulation. The purine de novo pathway and salvage pathway are tightly regulated by multiple enzymes, and dysfunction in ...
Jingchun Liu +7 more
semanticscholar +1 more source
Metabolomics and mass spectrometry imaging reveal channeled de novo purine synthesis in cells
Science, 2020 Signs of a metabolon in action Eukaryotic cells have a heterogeneous cytoplasm, with compartments large and small, membrane bound or not. Enzymes that catalyze the de novo synthesis of purine nucleotides, which are needed in rapidly dividing cells, are ...
V. Pareek +3 more
semanticscholar +1 more source
The Intersection of Purine and Mitochondrial Metabolism in Cancer
Cells, 2021 Nucleotides are essential to cell growth and survival, providing cells with building blocks for DNA and RNA, energy carriers, and cofactors. Mitochondria have a critical role in the production of intracellular ATP and participate in the generation of ...
Humberto de vitto +3 more
semanticscholar +1 more source
Nature Communications, 2021 Coagulase-negative staphylococci and Staphylococcus aureus colonize similar niches in mammals and conceivably compete for space and nutrients. Here, we report that a coagulase-negative staphylococcus, Staphylococcus chromogenes ATCC43764, synthesizes and
Denny Chin +6 more
semanticscholar +1 more source
bioRxiv, 2021 Intestinal epithelial cells are subject to attack by a diverse array of microbes, including intracellular as well as extracellular pathogens. While defense in epithelial cells can be triggered by pattern recognition receptor-mediated detection of microbe-
Eillen Tecle +5 more
semanticscholar +1 more source
Theranostics, 2020 Background: Gut microbiota, which plays a crucial role in inflammatory bowel diseases (IBD), might have therapeutic benefits for ulcerative colitis or Crohn's disease. Targeting gut microbiota represents a new treatment strategy for IBD patients.
Jiawei Wu +9 more
semanticscholar +1 more source
Purine metabolism regulates DNA repair and therapy resistance in glioblastoma
Nature Communications, 2020 Intratumoral genomic heterogeneity in glioblastoma (GBM) is a barrier to overcoming therapy resistance. Treatments that are effective independent of genotype are urgently needed.
Weihua Zhou +27 more
semanticscholar +1 more source
Molecules, 2020 Novel purine and purine isosteres containing a ferrocene motif and 4,1-disubstituted (11a−11c, 12a−12c, 13a−13c, 14a−14c, 15a−15c, 16a, 23a−23c, 24a−24c, 25a−25c) and 1,4-disubstituted (34a−34c and 35a−35c) 1,2,3-triazole rings were synthesized. The most
Valentina Rep +10 more
doaj +1 more source