Results 11 to 20 of about 151,646 (288)

A Novel Purine and Uric Metabolism Signature Predicting the Prognosis of Hepatocellular Carcinoma [PDF]

Frontiers in Genetics, 2022
Background: Hepatocellular carcinoma (HCC) is regarded as one of the most common cancers in the world with a poor prognosis. Patients with HCC often have abnormal purine and uric acid metabolism, but their relationship with prognosis is unclear.Methods ...
Shengjie Yang, Baoying Zhang, Weijuan Tan, Lu Qi, Xiao Ma, Xinghe Wang   +5 more
doaj   +2 more sources

Comprehensive measurement of purines in biological samples [PDF]

Frontiers in Analytical Science
Defects in numerous aspects of purine metabolism are well-recognized causes for human diseases. The applicability of ultra performance liquid chromatography (UPLC) with photodiode array (PDA) detection for analysis of the most abundant biological ...
Rong Fu, Diane J. Sutcliffe, Ashok R. Dinasarapu, Ellen J. Hess, Ellen J. Hess, H. A. Jinnah, H. A. Jinnah   +6 more
doaj   +2 more sources

Purine-Furan and Purine-Thiophene Conjugates [PDF]

Molbank, 2018
Furyl and thienyl moieties were introduced into a purine structure to elevate its fluorescence properties, while a trityl group was used to increase the amorphous properties of the purine compounds.
Zigfrīds Kapilinskis, Irina Novosjolova, Māris Turks   +2 more
doaj   +2 more sources

Protonated pyrimidine-purine-purine triplex [PDF]

Nucleic Acids Research, 1993
We have studied a protonated pyrimidine-purine-purine (Py-Pu-Pu) triplex, which is formed between the d(C)nd(G)n duplex and the d(AG)m oligonucleotide as the third strand and carries the CG*A+ protonated base-triads. We have observed such an intermolecular complex between a plasmid carrying the d(C)18 d(G)18 insert and the d(AG)5 oligonucleotide ...
V A, Malkov, O N, Voloshin, A G, Veselkov, V M, Rostapshov, I, Jansen, V N, Soyfer, M D, Frank-Kamenetskii   +6 more
openaire   +2 more sources

The major role of Listeria monocytogenes folic acid metabolism during infection is the generation of N-formylmethionine

mBio, 2023
Folic acid and its derivatives (folates) play central roles in one-carbon metabolism, necessary for the synthesis of purines, pyrimidines, and some amino acids.
Ying Feng, Shannon K. Chang, Daniel A. Portnoy   +2 more
doaj   +1 more source

Ferrocenoyl-adenines: substituent effects on regioselective acylation

Beilstein Journal of Organic Chemistry, 2022
A series of N6-substituted adenine–ferrocene conjugates was prepared and the reaction mechanism underlying the synthesis was explored. The SN2-like reaction between ferrocenoyl chloride and adenine anions is a regioselective process in which the product ...
Mateja Toma, Gabrijel Zubčić, Jasmina Lapić, Senka Djaković, Davor Šakić, Valerije Vrček   +5 more
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Assessment of the temporal trend and daily profiles of the dietary purine intake among Chinese residents during 2014 to 2021

Frontiers in Nutrition, 2023
The incidence of hyperuricemia is on the rise in China, primarily due to dietary habits. However, limited data exists regarding dietary purine intake in the country.
Shiwen Li, Xin Liu, Xiwu Jia, Min Fang, Qing Yang, Zhiyong Gong   +5 more
doaj   +1 more source

Structure-Based Design of 2-Aminopurine Derivatives as CDK2 Inhibitors for Triple-Negative Breast Cancer

Frontiers in Pharmacology, 2022
Cyclin-dependent kinase 2 (CDK2) regulates the progression of the cell cycle and is critically associated with tumor growth. Selective CDK2 inhibition provides a potential therapeutic benefit against certain tumors. Purines and related heterocycle (e.g.,
Hanzhi Liang, Yue Zhu, Zhiyuan Zhao, Jintong Du, Xinying Yang, Hao Fang, Xuben Hou   +6 more
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Purine and Purine Isostere Derivatives of Ferrocene: An Evaluation of ADME, Antitumor and Electrochemical Properties

Molecules, 2020
Novel purine and purine isosteres containing a ferrocene motif and 4,1-disubstituted (11a−11c, 12a−12c, 13a−13c, 14a−14c, 15a−15c, 16a, 23a−23c, 24a−24c, 25a−25c) and 1,4-disubstituted (34a−34c and 35a−35c) 1,2,3-triazole rings were synthesized. The most
Valentina Rep, Martina Piškor, Helena Šimek, Petra Mišetić, Petra Grbčić, Jasna Padovan, Vesna Gabelica Marković, Dijana Jadreško, Krešimir Pavelić, Sandra Kraljević Pavelić, Silvana Raić-Malić   +10 more
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Synthesis, Acidity Constants and Tautomeric Structure of the Diazonium Coupling Products of 2-(Benzylsulfanyl)-7H-purin-6-one in Its Ground and Excited States

Molecules, 2011
A series of new 8-arylhydrazono-2-(benzylsulfanyl)-7H-purin-6-ones 6 were synthesized, their electronic absorption spectra in different organic solvents of varying polarities were investigated and their acid dissociation constants in both the ground and ...
Hosam A. Saad, Farag M. Altalbawy, Elham S. Darwish, Mosselhi A. Mosselhi   +3 more
doaj   +1 more source