Results 21 to 30 of about 209,598 (340)

Assessment of the temporal trend and daily profiles of the dietary purine intake among Chinese residents during 2014 to 2021

Frontiers in Nutrition, 2023
The incidence of hyperuricemia is on the rise in China, primarily due to dietary habits. However, limited data exists regarding dietary purine intake in the country.
Shiwen Li, Xin Liu, Xiwu Jia, Min Fang, Qing Yang, Zhiyong Gong   +5 more
doaj   +1 more source

Structure-Based Design of 2-Aminopurine Derivatives as CDK2 Inhibitors for Triple-Negative Breast Cancer

Frontiers in Pharmacology, 2022
Cyclin-dependent kinase 2 (CDK2) regulates the progression of the cell cycle and is critically associated with tumor growth. Selective CDK2 inhibition provides a potential therapeutic benefit against certain tumors. Purines and related heterocycle (e.g.,
Hanzhi Liang, Yue Zhu, Zhiyuan Zhao, Jintong Du, Xinying Yang, Hao Fang, Xuben Hou   +6 more
doaj   +1 more source

Metabolomics and mass spectrometry imaging reveal channeled de novo purine synthesis in cells

Science, 2020
Signs of a metabolon in action Eukaryotic cells have a heterogeneous cytoplasm, with compartments large and small, membrane bound or not. Enzymes that catalyze the de novo synthesis of purine nucleotides, which are needed in rapidly dividing cells, are ...
V. Pareek, Hua Tian, N. Winograd, S. Benkovic   +3 more
semanticscholar   +1 more source

Rhein modulates host purine metabolism in intestine through gut microbiota and ameliorates experimental colitis

Theranostics, 2020
Background: Gut microbiota, which plays a crucial role in inflammatory bowel diseases (IBD), might have therapeutic benefits for ulcerative colitis or Crohn's disease. Targeting gut microbiota represents a new treatment strategy for IBD patients.
Jiawei Wu, Zhonghong Wei, P. Cheng, C. Qian, Fang-Yuan Xu, Yu Yang, Aiyun Wang, Wenxing Chen, Zhiguang Sun, Yin Lu   +9 more
semanticscholar   +1 more source

Purine metabolism regulates DNA repair and therapy resistance in glioblastoma

Nature Communications, 2020
Intratumoral genomic heterogeneity in glioblastoma (GBM) is a barrier to overcoming therapy resistance. Treatments that are effective independent of genotype are urgently needed.
Weihua Zhou, Yangyang Yao, A. Scott, K. Wilder-Romans, Joseph Dresser, C. Werner, Hanshi Sun, D. Pratt, Peter Sajjakulnukit, Shuang G Zhao, Mary A Davis, Barbara S Nelson, Christopher J. Halbrook, Li Zhang, F. Gatto, Y. Umemura, Angela K. Walker, M. Kachman, J. Sarkaria, J. Xiong, M. Morgan, Alnawaz Rehemtualla, M. Castro, P. Lowenstein, Sriram Chandrasekaran, T. Lawrence, C. Lyssiotis, D. Wahl   +27 more
semanticscholar   +1 more source

Purine and Purine Isostere Derivatives of Ferrocene: An Evaluation of ADME, Antitumor and Electrochemical Properties

Molecules, 2020
Novel purine and purine isosteres containing a ferrocene motif and 4,1-disubstituted (11a−11c, 12a−12c, 13a−13c, 14a−14c, 15a−15c, 16a, 23a−23c, 24a−24c, 25a−25c) and 1,4-disubstituted (34a−34c and 35a−35c) 1,2,3-triazole rings were synthesized. The most
Valentina Rep, Martina Piškor, Helena Šimek, Petra Mišetić, Petra Grbčić, Jasna Padovan, Vesna Gabelica Marković, Dijana Jadreško, Krešimir Pavelić, Sandra Kraljević Pavelić, Silvana Raić-Malić   +10 more
doaj   +1 more source

The Intersection of Purine and Mitochondrial Metabolism in Cancer

Cells, 2021
Nucleotides are essential to cell growth and survival, providing cells with building blocks for DNA and RNA, energy carriers, and cofactors. Mitochondria have a critical role in the production of intracellular ATP and participate in the generation of ...
Humberto de vitto, Danushka Arachchige, B. Richardson, J. French   +3 more
semanticscholar   +1 more source

Coagulase-negative staphylococci release a purine analog that inhibits Staphylococcus aureus virulence

Nature Communications, 2021
Coagulase-negative staphylococci and Staphylococcus aureus colonize similar niches in mammals and conceivably compete for space and nutrients. Here, we report that a coagulase-negative staphylococcus, Staphylococcus chromogenes ATCC43764, synthesizes and
Denny Chin, Mariya I. Goncheva, Ronald S. Flannagan, Shayna R. Deecker-Simon, Veronica Guariglia-Oropeza, Alexander W. Ensminger, D. Heinrichs   +6 more
semanticscholar   +1 more source

Synthesis, Acidity Constants and Tautomeric Structure of the Diazonium Coupling Products of 2-(Benzylsulfanyl)-7H-purin-6-one in Its Ground and Excited States

Molecules, 2011
A series of new 8-arylhydrazono-2-(benzylsulfanyl)-7H-purin-6-ones 6 were synthesized, their electronic absorption spectra in different organic solvents of varying polarities were investigated and their acid dissociation constants in both the ground and ...
Hosam A. Saad, Farag M. Altalbawy, Elham S. Darwish, Mosselhi A. Mosselhi   +3 more
doaj   +1 more source

Synthesis and Cytotoxic Activity of the Derivatives of N-(Purin-6-yl)aminopolymethylene Carboxylic Acids and Related Compounds

Molecules, 2023
Testing a number of N-[omega-(purin-6-yl)aminoalkanoyl] derivatives of 7,8-difluoro-3,4-dihydro-3-methyl-2H-[1,4]benzoxazine in a panel of nine tumor cell lines has shown that the studied compounds exhibit high cytotoxic activity, especially against 4T1 ...
Victor P. Krasnov, Olga A. Vozdvizhenskaya, Maria A. Baryshnikova, Alexandra G. Pershina, Vera V. Musiyak, Tatyana V. Matveeva, Kseniya V. Nevskaya, Olga Y. Brikunova, Dmitry A. Gruzdev, Galina L. Levit   +9 more
doaj   +1 more source