Purine nucleoside phosphorylase: A new marker for free oxygen radical injury to the endothelial cell [PDF]
, 1990 The effect of ischemia and reperfusion on purine nucleoside phosphorylase was studied in an isolated perfused rat liver model. This enzyme is localized primarily in the cytoplasm of the endothelial and Kupffer cells; some activity is associated with the ...
Abouna +32 more
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Purine nucleoside phosphorylase deficiency
Atlas of Inherited Metabolic Diseases, 2020 People with purine nucleoside phosphorylase deficiency have low numbers of immune system cells called T cells, which normally recognize and attack foreign invaders to prevent infection.
C. Staufner
semanticscholar +1 more source
The influence of the addition of polymers on the physico-chemical properties of bentonite suspensions [PDF]
Science of Sintering, 2014 Bentonite clays have many applications in industries ranging from construction to cosmetics. Addition of polymers can profoundly influence the properties of bentonite suspensions and we now describe the influence of a range of different polymers.
Stojiljkovic S. +7 more
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Ischemic preconditioning attenuates portal venous plasma concentrations of purines following warm liver ischemia in man [PDF]
, 2005 Background/Aims: Degradation of adenine nucleotides to adenosine has been suggested to play a critical role in ischemic preconditioning (IPC). Thus, we questioned in patients undergoing partial hepatectomy whether (i) IPC will increase plasma purine ...
Chouker, A. +9 more
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Frontiers in Medicine, 2021 Objective: To investigate the correlation between the structure and function alterations of gut microbiota and biochemical indicators in males with hyperuricemia (HUA) and high levels of liver enzymes, in order to provide new evidences and therapeutic ...
Shifeng Sheng +12 more
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Azathioprine and 6-mercaptopurine for maintenance of surgically-induced remission in Crohn’s disease [PDF]
, 2014 Background Crohn’s disease (CD) is a chronic relapsing inflammatory condition. Many patients fail to achieve remission with medical management and require surgical interventions.
Angelberger +41 more
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Unified prebiotically plausible synthesis of pyrimidine and purine RNA ribonucleotides
Science, 2019 Conditions right for making nucleosides In the absence of biological catalysts and metabolism, can atmospheric and geochemical processes provide the substrates and conditions required for production of biological molecules? Becker et al.
S. Becker +9 more
semanticscholar +1 more source
Cryo-EM structures demonstrate human IMPDH2 filament assembly tunes allosteric regulation
eLife, 2020 Inosine monophosphate dehydrogenase (IMPDH) mediates the first committed step in guanine nucleotide biosynthesis and plays important roles in cellular proliferation and the immune response. IMPDH reversibly polymerizes in cells and tissues in response to
Matthew C Johnson, Justin M Kollman
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Frontiers in Immunology, 2022 ObjectiveLimiting purine intake, inhibiting xanthine oxidoreductase (XOR) and inhibiting urate reabsorption in proximal tubule by uricosuric drugs, to reduce serum uric acid (UA) levels, are recognized treatments for gout.
Huanhuan Wang +9 more
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A Novel Purine and Uric Metabolism Signature Predicting the Prognosis of Hepatocellular Carcinoma
Frontiers in Genetics, 2022 Background: Hepatocellular carcinoma (HCC) is regarded as one of the most common cancers in the world with a poor prognosis. Patients with HCC often have abnormal purine and uric acid metabolism, but their relationship with prognosis is unclear.Methods ...
Shengjie Yang +5 more
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