Results 201 to 210 of about 28,518 (238)

Purine derivatives with antituberculosis activity

Russian Chemical Reviews, 2018
The review summarizes the data published over the last 10 – 15 years concerning the key groups of purine derivatives with antituberculosis activity. The structures of purines containing heteroatoms (S, O, N), fragments of heterocycles, amino acids and peptides ...
Dmitry A. Gruzdev, Vera V. Musiyak, Galina L. Levit, Victor P. Krasnov, Valery N. Charushin   +4 more
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Purine derivatives as potent γ-secretase modulators

Bioorganic & Medicinal Chemistry Letters, 2010
The development of a novel series of purines as gamma-secretase modulators for potential use in the treatment of Alzheimer's disease is disclosed herein. Optimization of a previously disclosed pyrimidine series afforded a series of potent purine-based gamma-secretase modulators with 300- to 2000-fold in vitro selectivity over inhibition of Notch ...
Alexey, Rivkin, Sean P, Ahearn, Stephanie M, Chichetti, Christopher L, Hamblett, Yudith, Garcia, Michelle, Martinez, Jed L, Hubbs, Michael H, Reutershan, Matthew H, Daniels, Phieng, Siliphaivanh, Karin M, Otte, Chaomin, Li, Andrew, Rosenau, Laura M, Surdi, Joon, Jung, Bethany L, Hughes, Jamie L, Crispino, George N, Nikov, Richard E, Middleton, Christopher M, Moxham, Alexander A, Szewczak, Sanjiv, Shah, Lily Y, Moy, Candia M, Kenific, Flobert, Tanga, Jonathan C, Cruz, Paula, Andrade, Minilik H, Angagaw, Nirah H, Shomer, Thomas, Miller, Benito, Munoz, Mark S, Shearman   +31 more
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Strukturanaloga der natürlichen Purin‐Derivate

Angewandte Chemie, 1961
AbstractDie Synthese von purin‐ähnlichen biheterocyclischen Ringsystemen wird beschrieben und insbesondere der Aufbau von verschieden substituierten Pyrazolo[3.4‐d] pyrimidinen ausgehend von Pyrazolen oder Pyrimidinen besprochen. Synthesewege für Pyrazolo[3.4‐c] pyridazine und Pyrazolo[3.4‐b] pyridine ausgehend von Pyridazinen und Pyridinen und von ...
Paul Schmidt, K. Eichenberger, M. Wilhelm   +2 more
openaire   +1 more source

Heterocyclic derivatives of purines. 5. Nucleophilic substitution in series of imidazo[1,2-f]purine derivatives

Chemistry of Heterocyclic Compounds, 1984
The chlorination of 1,8-dimethyl-7-phenylimidazo[1,2-f]xanthine with an equimolar amount of PCl5 in POCl3 leads to 2,4-dichloro-8-methyl-7-phenylimidazo[1,2-f]-purine. The possibility of substitution of the halogen atoms in reactions with nucleophilic reagents to give various 4-amino and 2,4-diamino derivatives was studied.
S. N. Garmash, B. A. Priimenko, N. A. Klyuev, N. I. Romanenko, A. K. Sheinkman   +4 more
openaire   +1 more source

Purine-Derived Ureides Under Drought and Salinity

2017
Abstract Purine-derived ureides (allantoin and allantoate) are the dominant nitrogenous (N) products transported from the root nodules to the aerial plant organs by rhizobia-nodulated (Rh + ) ureidic legumes. However, ureides are not exclusively synthesized in Rh + legumes as some evidence suggest a more universal ureide metabolism in C3 and C4 ...
Baral Bikash, Izaguirre-Mayoral Maria Luisa   +1 more
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Ugi–Smiles Couplings of Purine Derivatives

Synlett, 2016
Purines may be involved in Ugi–Smiles coupling as shown by the successful formation of thiocarboxamide derivatives from 6-mercaptopurine. This multicomponent coupling affords a very straightforward access to functionalized adenine derivatives, which are widely represented among natural products of medicinal interest.
El Kaim, Laurent, Abdessalem, Abdelbari, Abderrahim, Raoudha, dos Santos, Aurélie, Grimaud, Laurence   +4 more
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Purine- and Pyrimidine-derived Natural Products

2022
Pyrimidine- and purine-based natural products could qualify as alkaloids (e.g. caffeine) but we take up these nucleoside natural products as a separate subclass, given the centrality of uracil/5-methyluracil, cytosine, adenine, and guanine in nucleic acid metabolism, and as starting points for varied nucleoside scaffolds and their roles as plant ...
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ChemInform Abstract: FLUOROALKYL‐SUBSTITUTED PURINE DERIVATIVES

Chemischer Informationsdienst, 1976
Abstract8‐Bromtheophyllin (I) bildet mit dem Fluorepoxid (II) in Gegenwart von Pyridin das Purinderivat (III), das mit Dimethylsulfoxid/Acetanhydrid zum Keton (IV) oxidierbar ist.
U. WERNER, R. HALLER
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Purine derivatives as dapk1 inhibitors

2016
Derivados de purina como inhibidores de Dapk-1. La presente invención describe una nueva familia de derivados de purina que actúan como inhibidores selectivos de Dapk1. Se describe también el proceso para la obtención de los compuestos farmacéuticos y su uso como medicamento para el tratamiento o la profilaxis de enfermedades que precisan la inhibición
Molina Pineda Infantas, Ignacio Jesús, Torres Rusillo, Sara, Fernández Rubio, Pablo, Pineda de las Infantas y Villatoro, María J., Díaz Mochón, Juan José, Unciti-Broceta, Asier   +5 more
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Investigations in the purine series. II. Synthesis of some purine derivatives

Recueil des Travaux Chimiques des Pays-Bas, 1946
AbstractSyntheses of xanthine, 3,7‐, 1,3‐ and 1,7‐diethyl‐ and of 3‐ and 7‐monoethyl‐xanthines are described in this ...
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