Results 71 to 80 of about 28,518 (238)

Newly Synthesized Anticancer Purine Derivatives Inhibiting p-EIF4E Using Surface-Modified Lipid Nanovesicles. [PDF]

ACS Omega, 2023
Attia RT, Ewida MA, Khaled E, Fahmy SA, Fawzy IM.   +4 more
europepmc   +1 more source

Computer-aided rational design of acyclovir analogs to inhibit purine nucleoside phosphorylase

Pharmaceutical and Biomedical Research, 2019
Purine nucleoside phosphorylase (PNP) is one of the major enzymes in the purine salvage pathway. It is responsible for the elevation of deoxyguanosine, and thus considered as the potent target in T-cell lymphoma.
Nusrat Jahan Selsi, Lira Barua, Debpriya Bhattacharjee, Gulamur Rahman, Syeda Sakiatuz Zannat, Najia Absar Munia, Rubaiyat Fahad, Tanjiba Harun Bipasha, Azizur Rahman, Raju Dash   +9 more
doaj  

Synthesis of Novel 2,9-Disubstituted-6-morpholino Purine Derivatives Assisted by Virtual Screening and Modelling of Class I PI3K Isoforms. [PDF]

Polymers (Basel), 2023
Lobo V, Rocha A, Castro TG, Carvalho MA.
europepmc   +1 more source

Evaluation of the Sublimation Process of Some Purine Derivatives: Sublimation Rate, Activation Energy, Mass Transfer Coefficients and Phenomenological Models. [PDF]

Materials (Basel), 2022
Cleminte CI, Ionita D, Lisa C, Cristea M, Mamaligă I, Lisa G.   +5 more
europepmc   +1 more source

Effect of Cyclic Heat Exposure on the Growth Performance and Metabolism of Broilers Fed Palm Kernel Meal

Animal Research and One Health, EarlyView.
The aim of our study is to evaluate the interaction between HS and the incorporation of PKM in broiler chicken diets, as well as its effect on growth performance and metabolism. Based on the results obtained, PKM supplementation failed to mitigate the adverse effects of heat stress in broiler chickens. ABSTRACT The aim of this study was to evaluate the
Ahmed Mijiyawa, Elham Ghashghaei, Okasha Hamada, Huimin Wang, Lijing Sun, Yendouhamtchié Nadiedjoa, Dan Wang, Zhengkai Yue, Clarice Maa Maa Temhoul, Maxwell Ansong Okai, Muhammad Faisal Riaz, Felix Kwame Amevor, Wéré Pitala, Hai Lin   +13 more
wiley   +1 more source

Creatinine as a Urinary Marker of the Purine Derivatives Excretion in Urine Spot Samples of Lambs Fed Peach Palm Meal. [PDF]

Animals (Basel), 2022
Pereira TCJ, Pereira MLA, Carvalho GGP, Silva HGO, Dos Santos AB, Pina DDS, Sousa LB.   +6 more
europepmc   +1 more source

A Metabolomic Signature Predicts Gout Flare Clinical Outcome Associated With Colchicine Prophylaxis

Arthritis &Rheumatology, EarlyView.
Objective This study investigated that serum metabolomics, before urate‐lowering therapy (ULT) initiation, could serve as a biomarker for responsiveness to colchicine prophylaxis in patients with gout commencing treat‐to‐target ULT. Methods We studied a multicenter prospective cohort (n = 409) initiating treat‐to‐target ULT plus colchicine prophylaxis.
Wenyan Sun, Lingfang Xu, Haibing Chen, Mingshu Sun, Zhiqiang Li, Rui Li, Lidan Ma, Hui Zhang, Aichang Ji, Yuwei He, Na Wu, Le Yan, Robert Terkeltaub, Changgui Li   +13 more
wiley   +1 more source

Implications of Oxidative Stress in Glioblastoma Multiforme Following Treatment with Purine Derivatives. [PDF]

Antioxidants (Basel), 2021
Orlicka-Płocka M, Fedoruk-Wyszomirska A, Gurda-Woźna D, Pawelczak P, Krawczyk P, Giel-Pietraszuk M, Framski G, Ostrowski T, Wyszko E.   +8 more
europepmc   +1 more source

Inosine‐Triphosphate‐Pyrophosphatase Activity as a Potential Predictor of Methotrexate Remission in Juvenile Idiopathic Arthritis

Arthritis &Rheumatology, EarlyView.
Objective Methotrexate (MTX) is the first‐line therapy for juvenile idiopathic arthritis (JIA), but up to 40% of patients do not respond to it. Low inosine triphosphate pyrophosphatase (ITPA) activity has been associated with reduced clinical remission. We investigated the role and underlying mechanisms of ITPA in vitro. Methods ITPA enzymatic activity
Sofia Sindici Forgiarini, Marianna Lucafò, Debora Curci, Davide Selvestrel, Valentina Moressa, Sofia Pagarin, Barbara Bellich, Martina Franzin, Alberto Tommasini, Mara L. Becker, Laura B. Ramsey, Susan D. Thompson, Carl D. Langefeld, Federica Corba, Edoardo Marrani, Gabriele Simonini, Gabriele Stocco, Giuliana Decorti, Andrea Taddio, Serena Pastore   +19 more
wiley   +1 more source

Design, Synthesis, and In Vitro Antiproliferative Activity of Hydantoin and Purine Derivatives with the 4-Acetylphenylpiperazinylalkyl Moiety. [PDF]

Materials (Basel), 2021
Zagórska A, Czopek A, Jaromin A, Mielczarek-Puta M, Struga M, Stary D, Bajda M.   +6 more
europepmc   +1 more source