Results 181 to 190 of about 61,638 (306)

Deregulation of purine metabolism in Alzheimer's disease [PDF]

, 2014
Belén Ansoleaga, Mariona Jové, Agatha Schlüter, Paula Garcia‐Esparcia, Jesús Rodríguez Moreno, Aurora Pujol, Reinald Pamplona, Manuel Portero–Otín, Isidró Ferrer   +8 more
openalex   +1 more source

A STUDY OF THE METABOLISM OF PURINE RIBOSIDE [PDF]

Journal of Biological Chemistry, 1956
George Bosworth Brown, Milton P. Gordon
openaire   +2 more sources

Y12C mutation disrupts IMPDH cytoophidia and alters cancer metabolism

The FEBS Journal, EarlyView.
IMPDH, the rate‐limiting enzyme for de novo GTP synthesis, can form polymers and cytoophidia to enhance activity by reducing GTP inhibition. In this study, a Y12C mutation in IMPDH2 was introduced via ABEmax base‐editing in human cancer cell lines to disrupt IMPDH polymerisation.
Chia‐Chun Chang, Min Peng, Gerson Dierley Keppeke, Li‐Kuang Tsai, Ziheng Zhang, Li‐Mei Pai, Li‐Ying Sung, Ji‐Long Liu   +7 more
wiley   +1 more source

Single-Cell and Spatial Transcriptomics Explore Purine Metabolism-Related Prognostic Risk Model and Tumor Immune Microenvironment Modulation in Ovarian Cancer. [PDF]

Hum Mutat
Liu Y, Geng R, Zhao S, Yang J, Liu J, Zheng Y, Tang W.   +6 more
europepmc   +1 more source

Purine metabolism abnormalities in a hyperuricosuric subclass of autism

, 2000
Theodore Page, Mary Coleman
openalex   +1 more source

Saccharomyces cerevisiae Mub1, a substrate adaptor of E3 ubiquitin ligase Ubr2, modulates sensitivity to cell wall stressors through multiple transcription factors

The FEBS Journal, EarlyView.
We show that Mub1 links cell wall robustness with the ubiquitin‐proteasome system. As an adaptor protein of the E3 ubiquitin ligase Ubr2, it facilitates the ubiquitination of various transcription factors, including Mcm1 and Swi4. Yeasts evolved a complex regulatory programme to build and maintain their cell wall, the primary structure through which ...
Nada Šupljika, Antonia Paić, Ana Novačić, Tea Martinić Cezar, Béatrice Vallée, Renata Teparić, Igor Stuparević, Bojan Žunar   +7 more
wiley   +1 more source

A glucose-mediated antibiotic resistance metabolic flux from glycolysis, the pyruvate cycle, and glutamate metabolism to purine metabolism. [PDF]

Front Microbiol, 2023
Xiang J, Wang SW, Tao Y, Ye JZ, Liang Y, Peng XX, Yang LF, Li H.   +7 more
europepmc   +1 more source

Genetic Screen Reveals the Role of Purine Metabolism in Staphylococcus aureus Persistence to Rifampicin [PDF]

, 2015
Rebecca Yee, Peng Cui, Wanliang Shi, Jie Feng, Ying Zhang   +4 more
openalex   +1 more source

The G protein‐coupled receptor GPR89A is a novel potential therapeutic target to overcome cisplatin resistance in NSCLC Calu1 cells

The FEBS Journal, EarlyView.
A genome‐wide CRISPR‐Cas9‐based genetic screen in cisplatin‐resistant NSCLC cells revealed 63 potential candidate genes for overcoming cisplatin resistance, including GPR89A. GPR89A, localised in the Golgi, modulates voltage‐gated anion channel activity and is involved in intracellular pH reduction.
Hale Guler Kara, Eda Dogan, Vildan Bozok, Cagdas Aktan, Ece Cakiroglu, Zuhal Eroglu, Duygu Aygunes Jafari, Kemal Sami Korkmaz, Serif Senturk, Buket Kosova   +9 more
wiley   +1 more source

Purine metabolism in bone marrow microenvironment inhibits hematopoietic stem cell differentiation under microgravity. [PDF]

Stem Cell Res Ther
Liu X, Zhang H, Yan J, Ye P, Wang Y, Zhang N, Tian Z, Liu B, Yang H.   +8 more
europepmc   +1 more source