Results 211 to 220 of about 73,159 (260)

Purine Metabolism in Feline Lymphomas

Veterinary Pathology, 1990
Deficiency of the purine metabolic enzyme adenosine deaminase causes severe immunodeficiency. Retroviruses have been reported to decrease the activity of adenosine deaminase, and many retroviruses, including feline leukemia virus, cause immunodeficiency.
E A, Copelan, K S, Waddell, S C, Johnson, L, Mathes   +3 more
openaire   +2 more sources

Purine and Pyrimidine Metabolism

2013
Purine and pyrimidine nucleotides are essential for a vast number of biological processes such as RNA and DNA synthesis and as a component of high-energy nucleotides, e.g., adenosine triphosphate. Polygenic and Mendelian diseases are associated with altered purine and pyrimidine metabolism; thus, the genes associated with gout have only minor effects ...
Kamatani, Naoyuki, Jinnah, H. A., Hennekam, Raoul C. M., van Kuilenburg, André B. P.   +3 more
openaire   +1 more source

Purine metabolism in Schistosoma mansoni

International Journal for Parasitology, 1972
Abstract Schistosoma mansoni has been found to have a spectrum of purine nucleotides which is similar, but not identical to mammalian cells. The principal component of this system is ATP, which is present at a level of about 5·5 × 10 −9 moles/mg worm pairs.
A W, Senft, R P, Miech, P R, Brown, D G, Senft   +3 more
openaire   +2 more sources

Purine metabolism in human lymphocytes

Blut, 1979
In peripheral human blood lymphocytes the uptake and metabolism of adenine, guanine, and hypoxanthine was investigated. This was achieved by incubation of purified lymphocytes with 14C-purine bases, separation of cells from the incubation medium by a rapid filtration technique, and subsequent separation of the acid soluble material by thin-layer ...
M M, Müller, G, Pischek, O, Scheiner, H, Stemberger, G, Wiedermann   +4 more
openaire   +2 more sources

Purine metabolism in primitive erythrocytes

Comparative Biochemistry and Physiology Part B: Comparative Biochemistry, 1973
Abstract 1. 1. The activities of AMP kinase, GMP kinase, NDP kinase, PNPase and HGPRTase were determined in the erythrocytes of seal, eel, hagfish and dogfish. 2. 2. Erythrocytic NDP kinase activities were high and electrophoretically heterogeneous in all species examined. 3. 3.
R E, Parks, P R, Brown, Y C, Cheng, K C, Agarwal, C M, Kong, R P, Agarwal, C C, Parks   +6 more
openaire   +2 more sources

Purine metabolism in Trypanosoma cruzi

Molecular and Biochemical Parasitology, 1981
Culture forms of Trypanosoma cruzi are incapable of synthesizing purines de novo from formate, glycine, or serine and require an exogenous purine for growth. Adenine, hypoxanthine, guanine, xanthine and their respective ribonucleosides are equal in their abilities to support growth.
R L, Berens, J J, Marr, S W, LaFon, D J, Nelson   +3 more
openaire   +2 more sources

Metabolism of Purines and Pyrimidines

Annual Review of Biochemistry, 1956
The emphasis of recent reviews on structural aspects of nucleic acid chem­ istry and the substantial achievement represented by the publications of the past year on the metabolism of purine and pyrimidine nucleotides has led to the selection of enzymic reactions operative in the synthesis of these com­ pounds as the principal subject of this review ...
openaire   +2 more sources

Endothelial Purine Metabolism and Reperfusion Injury

Clinical Biochemistry, 1997
The endothelium shows high metabolic activity and thus influences a great number of physiological processes. Eicosanoids, thrombomodulin, protein S, and von Willebrand factor are important for the regulation of blood coagulation. By releasing eicosanoids and nitric oxide the endothelium is involved in the regulation of the vascular tone. Growth factors,
G, Weigel, A, Griesmacher, M M, Müller
openaire   +2 more sources

Extracellular purine metabolism

Drug Development Research, 1996
A variety of nucleotides and the nucleoside adenosine can act as extracellular signaling substances. Their function is terminated by extracellular degradation via surface-located enzymes. The breakdown products may be recycled. This review discusses recent developments in the cellular and molecular biology of enzymes involved in extracellular purine ...
openaire   +1 more source

PURINE METABOLISM IN NEISSERIA MENINGITIDIS

Acta Pathologica Microbiologica Scandinavica Section B Microbiology, 1975
Radioactive hypoxanthine and adenine were readily incorporated into the nucleic acids (RNA + DNA) of the prototrophic strain M1 of Neisseria meningitidis with labelling of the purine bases adenine and guanine. Contrary to this, adenine was incorporated into the nucleic acids with labelling of adenine only in the purine mutant 6‐1c which requires ...
S, Jyssum, K, Jyssum
openaire   +2 more sources