Results 61 to 70 of about 24,425 (290)
Combining simulations and solution experiments as a paradigm for RNA force field refinement [PDF]
J. Chem. Theory Comput., 2016, 12 (12), pp 6192-6200, 2016 Recent computational efforts have shown that the current potential energy models used in molecular dynamics are not accurate enough to describe the conformational ensemble of RNA oligomers and suggest that molecular dynamics should be complemented with experimental data.
arxiv +1 more source
A β-Fluoroamine Inhibitor of Purine Nucleoside Phosphorylase [PDF]
Journal of Medicinal Chemistry, 2008 The potent immucillin purine nucleoside phosphorylase (PNP ) inhibitors F-DADMe-ImmH [(3S,4S)-3], and [(3R,4R)-3] are synthesized in seven steps. Cycloaddition to a fluoroalkene and an enzymic resolution are the key features of the construction of the fluoropyrrolidines 11, from which the immucillins are assembled by use of a three-component Mannich ...
Graeme J. Gainsford +5 more
openaire +3 more sources
Molecular Pharmaceutics, 2018 Despite a wealth of potential applications inside target cells, protein-based therapeutics are largely limited to extracellular targets due to the inability of proteins to readily cross biological membranes and enter the cytosol.
Minyoung Park +8 more
semanticscholar +1 more source
Frontiers in Pharmacology, 2021 Neuroblastoma arises from neural crest cell precursors failing to complete the process of differentiation. Thus, agents helping tumor cells to differentiate into normal cells can represent a valid therapeutic strategy.
Natale Belluardo +13 more
doaj +1 more source
UV resistance of nucleosides -- an experimental approach [PDF]
, 2020 The emergence of life on Earth is a highly discussed but still unsolved question. Current research underlines the importance of environments within close proximity to the Earth's surface as they can solve long-standing problems such as polymerization of nucleotides and phosphorylation of nucleosides.
arxiv +1 more source
The Regulation of Brain Nucleoside Utilization [PDF]
, 2014 The homeostatic regulation of intracellular purine and pyrimidine pools has long been studied at the level of de novo nucleotide synthesis. However, brain maintains the proper qualitative and quantitative nucleotide balance by salvaging preformed ...
BALESTRI, FRANCESCO, IPATA, PIERO LUIGI
core +1 more source
Network Analysis of Biochemical Logic for Noise Reduction and Stability: A System of Three Coupled Enzymatic AND Gates [PDF]
J. Phys. Chem. B 113, 5301--5310 (2009), 2008 We develop an approach aimed at optimizing the parameters of a network of biochemical logic gates for reduction of the "analog" noise buildup. Experiments for three coupled enzymatic AND gates are reported, illustrating our procedure. Specifically, starch - one of the controlled network inputs - is converted to maltose by beta-amylase.
arxiv +1 more source
Enzymatic Synthesis of M1Gâ Deoxyribose [PDF]
, 2000 Adducts formed between electrophiles and nucleic acid bases are believed to play a key role in chemically induced mutations and cancer. M1Gâ dR is an endogenous exocyclic DNA adduct formed by the reaction of the dicarbonyl compound malondialdehyde with ...
Chapeau, Marie‐christine +2 more
core +1 more source
A Generalization of the Auslander-Reiten Conjecture for the Bounded Derived Category [PDF]
Archiv der Mathematik: Volume 98, Issue 6 (2012), Page 507-511, 2011 We study the bounded derived category $\D^b(\Rmod)$ of a left Noetherian ring $R$. We give a version of the Generalized Auslander-Reiten Conjecture for $\D^b(\Rmod)$ that is equivalent to the classical statement for the module category and is preserved under derived equivalence.
arxiv +1 more source
A specific adenosine phosphorylase, distinct from purine nucleoside phosphorylase
FEBS Letters, 1976 Several enzymes, catalyzing the reversible phosphorolysis of purine nucleosides have been described in eucaryotic cells and in micro-organisms [l-6] . The best known is the ‘purine nucleoside phosphorylase’ (EC 2.4.2.1) acting on the nucleosides of hypoxanthine and guanine. Adenosine is not used as substrate by this enzyme [6-81.
SENESI, SONIA +4 more
openaire +6 more sources