Results 1 to 10 of about 76,172 (181)

Degradation of brown adipocyte purine nucleotides regulates uncoupling protein 1 activity [PDF]

Molecular Metabolism, 2018
Objective: Non-shivering thermogenesis in mammalian brown adipose tissue depends on thermogenic uncoupling protein 1. Its activity is triggered by free fatty acids while purine nucleotides mediate inhibition.
Tobias Fromme, Karin Kleigrewe, Andreas Dunkel, Angelika Retzler, Yongguo Li, Stefanie Maurer, Natascha Fischer, Rolf Diezko, Timo Kanzleiter, Verena Hirschberg, Thomas Hofmann, Martin Klingenspor   +11 more
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Purine Nucleotides in the Regulation of Brown Adipose Tissue Activity [PDF]

Frontiers in Endocrinology, 2020
Non-shivering thermogenesis in mammalian brown adipose tissue is a powerful mechanism to defend normothermia in cold climates. To minimize the loss of chemical energy, the central functional component, mitochondrial uncoupling protein 1, UCP1, must be ...
Andrea Bast-Habersbrunner, Andrea Bast-Habersbrunner, Tobias Fromme, Tobias Fromme   +3 more
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Serine starvation suppresses the progression of esophageal cancer by regulating the synthesis of purine nucleotides and NADPH [PDF]

Cancer & Metabolism
Serine metabolism provides important metabolic intermediates that support the rapid proliferation of tumor cells. However, the role of serine metabolism in esophageal squamous cell carcinoma (ESCC) and the underlying mechanism remains unclear.
Hui Jie, Jing Wei, Zhuoling Li, Min Yi, Xinying Qian, Yan Li, Chunqi Liu, Chuan Li, Liang Wang, Pengchi Deng, Lunxu Liu, Xiaobo Cen, Yinglan Zhao   +12 more
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Phase separation of the PRPP amidotransferase into dynamic condensates promotes de novo purine synthesis in yeast. [PDF]

PLoS Biology
De novo purine synthesis (DPS) is up-regulated under conditions of high purine demand to ensure the production of genetic materials and chemical energy, thereby supporting cell proliferation.
Masak Takaine, Rikuri Morita, Yuto Yoshinari, Takashi Nishimura   +3 more
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Research Advances in Purine Phosphoribosyltransferases of Protozoan Parasites

Guangdong nongye kexue, 2023
Parasitic protozoa are single-celled organisms that have adapted to live in cells of humans and animals. The protozoan parasites include Leishmania spp., Trypanosoma spp., Plasmodium spp., Toxoplasma gondii, Cryptosporidium spp., and Eimeria spp., which ...
Zhihui YU, Siyun FANG, Mingfei SUN, Nanshan QI, Wenjun LIU, Juan LI, Junjing HU, Shenquan LIAO   +7 more
doaj   +1 more source

Molecular determinants of inhibition of UCP1-mediated respiratory uncoupling

Nature Communications, 2023
Brown adipose tissue expresses uncoupling protein 1 (UCP1), which dissipates energy as heat, making it a target for treating metabolic disorders. Here, we investigate how purine nucleotides inhibit respiration uncoupling by UCP1.
Antoine Gagelin, Corentin Largeau, Sandrine Masscheleyn, Mathilde S. Piel, Daniel Calderón-Mora, Frédéric Bouillaud, Jérôme Hénin, Bruno Miroux   +7 more
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Inborn Errors of Purine Salvage and Catabolism

Metabolites, 2023
Cellular purine nucleotides derive mainly from de novo synthesis or nucleic acid turnover and, only marginally, from dietary intake. They are subjected to catabolism, eventually forming uric acid in humans, while bases and nucleosides may be converted ...
Marcella Camici, Mercedes Garcia-Gil, Simone Allegrini, Rossana Pesi, Giulia Bernardini, Vanna Micheli, Maria Grazia Tozzi   +6 more
doaj   +1 more source

Selective Fluorimetric Detection of Pyrimidine Nucleotides in Neutral Aqueous Solution with a Styrylpyridine-Based Cyclophane

Chemistry, 2023
A styrylpyridine-containing cyclophane with diethylenetriamine linkers is presented as a host system whose association with representative nucleotides was examined with photometric and fluorimetric titrations.
Julika Schlosser, Julian F. M. Hebborn, Daria V. Berdnikova, Heiko Ihmels   +3 more
doaj   +1 more source

In silico-guided metabolic engineering of Bacillus subtilis for efficient biosynthesis of purine nucleosides by blocking the key backflow nodes

Biotechnology for Biofuels and Bioproducts, 2022
Background Purine nucleosides play essential roles in cellular physiological processes and have a wide range of applications in the fields of antitumor/antiviral drugs and food. However, microbial overproduction of purine nucleosides by de novo metabolic
Aihua Deng, Qidi Qiu, Qinyun Sun, Zhenxiang Chen, Junyue Wang, Yu Zhang, Shuwen Liu, Tingyi Wen   +7 more
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Probing ligand selectivity in pathogens

eLife, 2023
Why does protein kinase A respond to purine nucleosides in certain pathogens, but not to the cyclic nucleotides that activate this kinase in most other organisms?
Bryan VanSchouwen, Giuseppe Melacini
doaj   +1 more source