Purine Nucleotides in the Regulation of Brown Adipose Tissue Activity [PDF]
Frontiers in Endocrinology, 2020 Non-shivering thermogenesis in mammalian brown adipose tissue is a powerful mechanism to defend normothermia in cold climates. To minimize the loss of chemical energy, the central functional component, mitochondrial uncoupling protein 1, UCP1, must be ...
Andrea Bast-Habersbrunner +3 more
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Degradation of brown adipocyte purine nucleotides regulates uncoupling protein 1 activity [PDF]
Molecular Metabolism, 2018 Objective: Non-shivering thermogenesis in mammalian brown adipose tissue depends on thermogenic uncoupling protein 1. Its activity is triggered by free fatty acids while purine nucleotides mediate inhibition.
Tobias Fromme +11 more
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Inborn Errors of Purine Salvage and Catabolism
Metabolites, 2023 Cellular purine nucleotides derive mainly from de novo synthesis or nucleic acid turnover and, only marginally, from dietary intake. They are subjected to catabolism, eventually forming uric acid in humans, while bases and nucleosides may be converted ...
Marcella Camici +6 more
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Purine Nucleotide Availability Regulates mTORC1 Activity through the Rheb GTPase [PDF]
Cell Reports, 2017 Pharmacologic agents that interfere with nucleotide metabolism constitute an important class of anticancer agents. Recent studies have demonstrated that mTOR complex 1 (mTORC1) inhibitors suppress de novo biosynthesis of pyrimidine and purine nucleotides.
Natasha Emmanuel +9 more
doaj +2 more sources
De Novo Purine Nucleotide Biosynthesis Pathway Is Required for Development and Pathogenicity in Magnaporthe oryzae [PDF]
Journal of Fungi, 2022 Purine nucleotides are indispensable compounds for many organisms and participate in basic vital activities such as heredity, development, and growth. Blocking of purine nucleotide biosynthesis may inhibit proliferation and development and is commonly ...
Meng-Yu Liu +9 more
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Serine starvation suppresses the progression of esophageal cancer by regulating the synthesis of purine nucleotides and NADPH [PDF]
Cancer & MetabolismSerine metabolism provides important metabolic intermediates that support the rapid proliferation of tumor cells. However, the role of serine metabolism in esophageal squamous cell carcinoma (ESCC) and the underlying mechanism remains unclear.
Hui Jie +12 more
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Phytohormones: structural and functional relationship to purine nucleotides and some pharmacologic agents. [PDF]
Plant Signal Behav, 2021 Williams WR.
europepmc +3 more sources
Research Advances in Purine Phosphoribosyltransferases of Protozoan Parasites
Guangdong nongye kexue, 2023 Parasitic protozoa are single-celled organisms that have adapted to live in cells of humans and animals. The protozoan parasites include Leishmania spp., Trypanosoma spp., Plasmodium spp., Toxoplasma gondii, Cryptosporidium spp., and Eimeria spp., which ...
Zhihui YU +7 more
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Molecular determinants of inhibition of UCP1-mediated respiratory uncoupling
Nature Communications, 2023 Brown adipose tissue expresses uncoupling protein 1 (UCP1), which dissipates energy as heat, making it a target for treating metabolic disorders. Here, we investigate how purine nucleotides inhibit respiration uncoupling by UCP1.
Antoine Gagelin +7 more
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