Results 141 to 150 of about 76,319 (326)

Discovery‐Replication Strategy Identifies Serum Metabolite Biomarkers for Colorectal Cancer in a Chinese Cohort

Cancer Science, EarlyView.
This study used an untargeted metabolomics approach to screen for serum differentially abundant metabolites in colorectal cancer (CRC) patients, and after analyzing a discovery cohort and validation cohort, eight metabolites and their constituent panels were identified as not only having diagnostic value for CRC but also showing value for the early ...
Lugen Zuo, Bowen Song, Xuening Jiang, Jing Li, Xiaofeng Zhang, Lian Wang, Yueyue Wang, Zhijun Geng, Xue Song, Sitang Ge, Jianguo Hu   +10 more
wiley   +1 more source

Synthetic Nucleosides and Nucleotides. III. On the Syntheses of Several 2, 6, 8-Trisubstituted Purine Ribonucleosides

, 1968
Mineo Saneyoshi
openalex   +2 more sources

Generation and Auditory Phenotypic Characterization of Prps1 p.Ala87Thr Mouse Knock‐In Model for Human DFNX1 Deafness

Clinical Genetics, EarlyView.
Our mouse model with a c.259G>A transition in PRPS1 showed a significant decrease in the number of hair cells and SGN counts at 48 weeks of age and a reduction in Prps1 enzymatic activity in the KI mouse. This model will serve as a valuable tool for developing therapeutic strategies.
Denise Yan, M'hamed Grati, Rahul Mittal, Yi‐Zhou Quan, Wan Du, Zheng‐Yi Chen, Xue Zhong Liu   +6 more
wiley   +1 more source

Studies of Nucleosides and Nucleotides. XXV. Purine Cyclonucleosides. 2. Synthesis of 5'-Deoxyguanosine via an 5', 8-Cyclonucleoside

, 1965
Morio Ikehara, Hiroshi Tada, Kei Muneyama   +2 more
openalex   +2 more sources

WONOEP XVII appraisal: Targeting network excitability beyond the synapse ‐Neurotransmitter, ionic, and electro ‐diffusions

Epilepsia, EarlyView.
Abstract Epilepsy affects approximately 1% of the population worldwide, and although medications are effective in the majority of cases, seizures persist in approximately 30% of patients. Despite the effort to develop new antiseizure drugs, the rate of pharmacoresistance in patients has not diminished over the past 3 decades. There is thus a real unmet
Vincent Magloire, Marco de Curtis, Jeffrey Noebels, Gilles Huberfeld, Piotr Suffczynski, Vadym Gnatkovsky, Olga Tyurikova, Dominique Durand, David C. Henshall, Cian McCafferty   +9 more
wiley   +1 more source

Inhibition of mitochondrial UCP1 and UCP3 by purine nucleotides and phosphate. [PDF]

Biochim Biophys Acta Biomembr, 2018
Macher G, Koehler M, Rupprecht A, Kreiter J, Hinterdorfer P, Pohl EE.   +5 more
europepmc   +1 more source

Studies of Nucleosides and Nucleotides. XXIII. A Versatile Method for Replacement of 6-Hydroxyl Group of Purine Nucleoside.

, 1964
Morio Ikehara, Hitoshi Uno, Fumiyoshi Ishikawa   +2 more
openalex   +2 more sources

Skeletal muscle purine nucleotide levels in normal and phosphorylase kinase deficient mice [PDF]

, 1976
Z.H.A. Rahim, David I. Perrett, John R. Griffiths   +2 more
openalex   +1 more source

Stress exposure in the mdx mouse model of Duchenne muscular dystrophy provokes a widespread metabolic response

The FEBS Journal, EarlyView.
A targeted mass spectrometry‐based metabolomics assay was conducted to identify the impact of stress exposure on the regulation of biological stress pathways in the mdx mouse model of Duchenne muscular dystrophy. We demonstrated a broad shift in the circulating stress‐relevant plasma metabolome associated with stressful scruff handling that was ...
Erynn E. Johnson, James M. Ervasti
wiley   +1 more source

The Distribution of Purine Nucleotides in 2 Viral Ribonucleic Acid

, 1968
H.R. Matthews
openalex   +1 more source