Results 141 to 150 of about 661,667 (342)

High‐Altitude Adaptation of Frogs (Case Study: Nanorana parkeri): From Physiological Phenotypes to AltitudeOmics

Integrative Zoology, EarlyView.
High altitudes are challenging for the animals that inhabit these environments. The Xizang plateau frog (Nanorana parkeri) survives in high‐altitude environments through a synergistic strategy of metabolic remodeling and protein expression adjustment to optimize energy efficiency and enhance cellular protection.
Xuejing Zhang, Yonggang Niu, Shengkang Men, Yanghuilin Zhang, Xiaolong Tang, Kenneth B. Storey, Qiang Chen   +6 more
wiley   +1 more source

The potential for biased signalling in the P2Y receptor family of GPCRs

British Journal of Pharmacology, EarlyView.
The purinergic receptor family is primarily activated by nucleotides, and contains members of both the G protein coupled‐receptor (GPCR) superfamily (P1 and P2Y) and ligand‐gated ion channels (P2X). The P2Y receptors are widely expressed in the human body, and given the ubiquitous nature of nucleotides, purinergic signalling is involved with a plethora
Claudia M. Sisk, Simon Pitchford, Graham Ladds   +2 more
wiley   +1 more source

ENZYMATIC SYNTHESIS OF PURINE NUCLEOTIDES

Journal of Biological Chemistry, 1955
A, KORNBERG, I, LIEBERMAN, E S, SIMMS
openaire   +2 more sources

A possible role for 5-phosphoribosyl 1-pyrophosphate in the stimulation of uterine purine nucleotide synthesis in response to oestradiol-17β

, 1972
Janet M. Oliver
openalex   +2 more sources

Comparison of human erythrocyte purine nucleotide metabolism and blood purine and pyrimidine degradation product concentrations before and after acute exercise in trained and sedentary subjects [PDF]

, 2017
Wioleta Dudzińska, M. Suska, Anna Lubkowska, Katarzyna Jakubowska, Maria Olszewska, Krzysztof Safranow, Dariusz Chlubek   +6 more
openalex   +1 more source

Novel approaches for drug development against chronic primary pain: A systematic review

British Journal of Pharmacology, EarlyView.
Abstract Chronic primary pain (CPP) persisting for more than 3 months, associated with significant emotional distress without any known underlying cause, is an unmet medical need. Traditional or adjuvant analgesics do not provide satisfactory pain relief for a great proportion of these patients.
Valéria Tékus, Éva Borbély, Andreas Goebel, Ralf Baron, Zsófia Hajna, Zsuzsanna Helyes   +5 more
wiley   +1 more source

IMPDH2 dephosphorylation under FGFR signaling promotes S-phase progression and tumor growth

Cell Reports
Summary: Inosine monophosphate dehydrogenase 2 (IMPDH2) is highly expressed in human cancers; however, its physiological relevance under growth signaling remains to be investigated. Here, we show that IMPDH2 serine 122 is phosphorylated by CDK1, and this
Bei Zhou, Qin Zhao, Guofang Hou, Jing He, Nannan Sha, Ke Zheng, Hongyu Peng, Wang Wang, Yue Zhou, Tao Chen, Yuhui Jiang   +10 more
doaj   +1 more source

Studies of Nucleosides and Nucleotides. XXXII. Purine Cyclonucleosides. 3. Synthesis of 2'-Deoxy- and 3'-Deoxyadenosine from Adenosine

, 1967
Morio Ikehara, Hiroshi Tada
openalex   +2 more sources

A role for adenine nucleotides in the sensing mechanism to purine starvation in Leishmania donovani

Molecular Microbiology, 2016
Jessica L Martin, P. Yates, Jan M. Boitz, D. Koop, Audrey L Fulwiler, M. Cassera, B. Ullman, N. Carter   +7 more
semanticscholar   +1 more source

Severe Prenatal Presentation of Adenylosuccinate Lyase Deficiency Caused by a Synonymous ADSL Variant Inducing Aberrant Splicing

Prenatal Diagnosis, EarlyView.
Aysegül Klapperich, Vaclava Skopova, Mert Karakaya, Clara Velmans, Christian Netzer, Brigitte Strizek, Lenka Steiner Mrazova, Marie Zikanova   +7 more
wiley   +1 more source