Results 11 to 20 of about 661,667 (342)

A journey into the regulatory secrets of the de novo purine nucleotide biosynthesis

Frontiers in Pharmacology
De novo purine nucleotide biosynthesis (DNPNB) consists of sequential reactions that are majorly conserved in living organisms. Several regulation events take place to maintain physiological concentrations of adenylate and guanylate nucleotides in cells ...
Nour Ayoub, Antoine Gedeon, Hélène Munier-Lehmann   +2 more
doaj   +2 more sources

Inhibition of mitochondrial UCP1 and UCP3 by purine nucleotides and phosphate. [PDF]

Biochim Biophys Acta Biomembr, 2018
Macher G, Koehler M, Rupprecht A, Kreiter J, Hinterdorfer P, Pohl EE.   +5 more
europepmc   +2 more sources

Quantitative analysis of purine nucleotides indicates that purinosomes increase de novo purine biosynthesis. [PDF]

J Biol Chem, 2015
Background: Metabolic enzymes have been hypothesized to assemble into complex to respond to cellular metabolism changes. Results: De novo purine biosynthesis increases in purinosome-containing cells.
Zhao H, Chiaro CR, Zhang L, Smith PB, Chan CY, Pedley AM, Pugh RJ, French JB, Patterson AD, Benkovic SJ.   +9 more
europepmc   +2 more sources

Structural basis of purine nucleotide inhibition of human uncoupling protein 1

Science Advances, 2023
Mitochondrial uncoupling protein 1 (UCP1) gives brown adipose tissue of mammals its specialized ability to burn calories as heat for thermoregulation.
Scott A Jones, Prerana Gogoi, J. Ruprecht, Martin S. King, Yang Lee, Thomas Zögg, E. Pardon, Deepak Chand, Stefan Steimle, Danielle M Copeman, Camila A. Cotrim, J. Steyaert, Paul G. Crichton, V. Moiseenkova-Bell, Edmund R. S. Kunji   +14 more
semanticscholar   +1 more source

In silico-guided metabolic engineering of Bacillus subtilis for efficient biosynthesis of purine nucleosides by blocking the key backflow nodes

Biotechnology for Biofuels and Bioproducts, 2022
Background Purine nucleosides play essential roles in cellular physiological processes and have a wide range of applications in the fields of antitumor/antiviral drugs and food. However, microbial overproduction of purine nucleosides by de novo metabolic
Aihua Deng, Qidi Qiu, Qinyun Sun, Zhenxiang Chen, Junyue Wang, Yu Zhang, Shuwen Liu, Tingyi Wen   +7 more
doaj   +1 more source

Selective Fluorimetric Detection of Pyrimidine Nucleotides in Neutral Aqueous Solution with a Styrylpyridine-Based Cyclophane

Chemistry, 2023
A styrylpyridine-containing cyclophane with diethylenetriamine linkers is presented as a host system whose association with representative nucleotides was examined with photometric and fluorimetric titrations.
Julika Schlosser, Julian F. M. Hebborn, Daria V. Berdnikova, Heiko Ihmels   +3 more
doaj   +1 more source

Probing ligand selectivity in pathogens

eLife, 2023
Why does protein kinase A respond to purine nucleosides in certain pathogens, but not to the cyclic nucleotides that activate this kinase in most other organisms?
Bryan VanSchouwen, Giuseppe Melacini
doaj   +1 more source

Purine nucleotide depletion prompts cell migration by stimulating the serine synthesis pathway

Nature Communications, 2022
Nucleotides are essential for different biological processes and have been also associated to cancer development. Depleting cellular nucleotides is a strategy commonly employed to target cancers.
Mona Hoseini Soflaee, Rushendhiran Kesavan, Umakant Sahu, Alpaslan Tasdogan, Elodie Villa, Zied Djabari, Feng Cai, Diem H. Tran, Hieu S. Vu, Eunus S. Ali, Halie Rion, Brendan P. O’Hara, Sherwin Kelekar, James Hughes Hallett, Misty Martin, Thomas P. Mathews, Peng Gao, John M. Asara, Brendan D. Manning, Issam Ben-Sahra, Gerta Hoxhaj   +20 more
doaj   +1 more source

Nucleotides: Structure and Properties [PDF]

, 2005
Nucleotides consist of a nitrogen-containing base, a five-carbon sugar, and one or more phosphate groups. Cells contain many types of nucleotides, which play a central role in a wide variety of cellular processes, including metabolic regulation and the ...
Bowater, RP
core   +1 more source

Potential Mechanisms Connecting Purine Metabolism and Cancer Therapy

Frontiers in Immunology, 2018
Unrestricted cell proliferation is a hallmark of cancer. Purines are basic components of nucleotides in cell proliferation, thus impaired purine metabolism is associated with the progression of cancer.
Jie Yin, Jie Yin, Jie Yin, Wenkai Ren, Xingguo Huang, Xingguo Huang, Jinping Deng, Tiejun Li, Yulong Yin, Yulong Yin   +9 more
doaj   +1 more source