Results 241 to 250 of about 76,319 (326)

Metabolic Reprogramming: A Crucial Contributor to Anticancer Drug Resistance

MedComm, Volume 6, Issue 9, September 2025.
Role of metabolic reprogramming in drug resistance in cancer: Metabolic reprogramming in cancer cells profoundly impacts the responsiveness of these cells to drugs. Cancer cells rewire the flux of the metabolism of the three major nutrients, glucose, lipid, and amino acids, leading to abnormalities in drug orientation, defects in cell death mechanisms,
Yunhan Zhu, Weijie Yan, Lingfeng Tong, Jie Yang, Shengfang Ge, Jiayan Fan, Renbing Jia, Xuyang Wen   +7 more
wiley   +1 more source

Proton conductance by human uncoupling protein 1 is inhibited by purine and pyrimidine nucleotides. [PDF]

EMBO J
Jones SA, Sowton AP, Lacabanne D, King MS, Palmer SM, Zögg T, Pardon E, Steyaert J, Ruprecht JJ, Kunji ERS.   +9 more
europepmc   +1 more source

Repurposing Mercaptopurine Through Collateral Lethality to Treat Cancers with Somatic RB1–NUDT15 Loss

MedComm, Volume 6, Issue 9, September 2025.
In this study, we found the close proximity of NUDT15 and RB1 in terms of chromosome location and exploited the fact that NUDT15 deficiency induces 6MP‐related adverse drug reactions, thus providing a possible collateral lethality (a specific type of synthetic lethality) strategy to treat RB1‐deficient tumors (created with www.biorender.com).
Tao Zhou, Huayun Yan, Dandan Yin, Yun Deng, Huancheng Fu, Zichen Zhao, Shuang Li, Xiaoxi Lu, Yiqi Deng, Hai‐Ning Chen, Wei‐Han Zhang, Yunying Shi, Yangjuan Bai, Bei Cai, Lanlan Wang, Zhaoqian Liu, Wei Zhang, Lili Jiang, Yang Shu, Bo Liu, Yan Zhang, Heng Xu   +21 more
wiley   +1 more source

Identification of picornavirus proteins that inhibit de novo nucleotide synthesis during infection. [PDF]

PLoS Pathog
Nouwen LV, Zaal EA, Buitendijk I, Zwaagstra M, Aloise C, van Vliet ALW, Schipper JG, van Mil A, Berkers CR, van Kuppeveld FJM.   +9 more
europepmc   +1 more source

Regulation of levels of purine biosynthetic enzymes in Bacillus subtilis: effects of changing purine nucleotide pools

, 1991
Hans H. Saxild, Per Nygaard
openalex   +1 more source

Exosome‐Based Therapeutics: A Natural Solution to Overcoming the Blood–Brain Barrier in Neurodegenerative Diseases

MedComm, Volume 6, Issue 9, September 2025.
Therapies for neurodegenerative diseases (NDs) are constrained by the blood–brain barrier (BBB), which limits drug delivery. Exosomes, with their ability to cross BBB and deliver drugs efficiently, emerge as a promising platform for central nervous system‐targeted therapies. ABSTRACT Neurodegenerative diseases present significant therapeutic challenges,
Min Sun, Feng Qin, Qian Bu, Yue Zhao, Xiaofeng Yang, Dingwen Zhang, Xiaobo Cen   +6 more
wiley   +1 more source

Ionization of DNA Nucleotides in Explicit Solution. [PDF]

Molecules
Bai J, Zhang Y, Yin S, Che L, Yang S.
europepmc   +1 more source

Primary Progressive Multiple Sclerosis: New Therapeutic Approaches

Neuropsychopharmacology Reports, Volume 45, Issue 3, September 2025.
Primary progressive MS affects 10%–15% of MS patients, causing irreversible neurological impairment. Drugs like ocrelizumab show promise, while high‐dose biotin, simvastatin, and coenzyme Q10 are under investigation. Gene therapy and stem cell treatments also show potential.
Morteza Rajabi, Sajjad Shafaeibajestan, Sevda Asadpour, Ghazal Alyari, Niloofar Taei, Moein Kohkalani, Ramin Raoufinia, Hamed Afarande, Ehsan Saburi   +8 more
wiley   +1 more source

RpoB8, a rifampicin-resistant termination-proficient RNA polymerase, has an increased Km for purine nucleotides during transcription elongation

, 1991
Dan Jin, Carol A. Gross
openalex   +1 more source

Impact of Confounding Factors in Human Postmortem Brain Tissues on Gene Expression Profiles: A Comparison of Patients With Schizophrenia, Bipolar Disorder, and Nonpsychiatric Controls

Neuropsychopharmacology Reports, Volume 45, Issue 3, September 2025.
This study examined the impact of confounding factors on gene expression in postmortem brain tissue from individuals with psychiatric disorders. The expression was significantly associated with factors such as pH, RIN, PMI, and storage duration, highlighting the importance of accounting for these variables when interpreting transcriptomic data ...
Masataka Hatano, Atsuko Nagaoka, Kazusa Miyahara, Yuto Hosogai, Risa Shishido, Hideomi Hamasaki, Mizuki Hino, Akiyoshi Kakita, Hiroaki Tomita, Yasuto Kunii, Itaru Miura   +10 more
wiley   +1 more source