Results 21 to 30 of about 77,707 (283)

De Novo Purine Nucleotide Biosynthesis Pathway Is Required for Development and Pathogenicity in Magnaporthe oryzae

Journal of Fungi, 2022
Purine nucleotides are indispensable compounds for many organisms and participate in basic vital activities such as heredity, development, and growth. Blocking of purine nucleotide biosynthesis may inhibit proliferation and development and is commonly ...
Meng-Yu Liu, Li-Xiao Sun, Hui Qian, Yun-Ran Zhang, Xue-Ming Zhu, Lin Li, Shuang Liang, Jian-Ping Lu, Fu-Cheng Lin, Xiao-Hong Liu   +9 more
doaj   +1 more source

FAMIN Is a Multifunctional Purine Enzyme Enabling the Purine Nucleotide Cycle [PDF]

Cell, 2020
Mutations in FAMIN cause arthritis and inflammatory bowel disease in early childhood, and a common genetic variant increases risk for Crohn’s disease and leprosy. We developed an unbiased liquid chromatography mass spectrometry screen for enzymatic activity of this orphan protein.
Cader, M Zaeem, Rodrigues, Rodrigo Pereira De Almeida, West, James A, Sewell, Gavin W, Md-Ibrahim, Muhammad N, Reikine, Stephanie, Sirago, Giuseppe, Unger, Lukas W, Iglesias Romero, Ana Bélen, Ramshorn, Katharina, Haag, Lea-Maxie, Saveljeva, Svetlana, Ebel, Jana-Fabienne, Rosenstiel, Philip, Kaneider-Kaser, Nicole C, Lee, James C, Lawley, Trevor D, Bradley, Allan, Dougan, Gordon, Modis, Yorgo, Griffin, Julian L, Kaser, Arthur   +21 more
openaire   +7 more sources

Attenuation of ischemic liver injury by prostaglandin E1 analogue, misoprostol, and prostaglandin I2 analogue, OP-41483 [PDF]

, 1998
Background: Prostaglandin has been reported to have protective effects against liver injury. Use of this agent in clinical settings, however, is limited because of drugrelated side effects.
Ishizaki, N, Jin, MB, Kawashima, Y, Shimamura, T, Starzl, TE, Todo, S, Totsuka, E, Urakami, A, Zhu, Y   +8 more
core   +1 more source

Urinary ATP Levels Are Controlled by Nucleotidases Released from the Urothelium in a Regulated Manner

Metabolites, 2022
Adenosine 5′-triphosphate (ATP) is released in the bladder lumen during filling. Urothelial ATP is presumed to regulate bladder excitability. Urinary ATP is suggested as a urinary biomarker of bladder dysfunctions since ATP is increased in the urine of ...
Alejandro Gutierrez Cruz, Mafalda S. L. Aresta Branco, Brian A. Perrino, Kenton M. Sanders, Violeta N. Mutafova-Yambolieva   +4 more
doaj   +1 more source

One-carbon metabolism in cancer [PDF]

, 2017
Cells require one-carbon units for nucleotide synthesis, methylation and reductive metabolism, and these pathways support the high proliferative rate of cancer cells.
AJ MacFarlane, Alice C Newman, AS Tibbetts, B Chaneton, BC Blount, C Commisso, CA Lewis, CF Labuschagne, CF Woeller, D Hanahan, D Hanahan, D Kim, DD Anderson, E Currie, E Mullarky, F Daidone, F Kottakis, G Kikuchi, GM DeNicola, Gregory S. Ducker, GS Ducker, J Liu, J Meiser, J Ye, Jason W. Locasale, JJ Kamphorst, JW Locasale, K Snell, K Snell, K Snell, Katherine R. Mattaini, L Galluzzi, M Goulian, M Jain, M Kulis, Mahya Mehrmohamadi, ME Pacold, Ming Yang, MJ Osborn, ML Rose, ML Rose, OD Maddocks, OD Maddocks, Oliver D K Maddocks, Oliver D. K. Maddocks, PM Ueland, R Possemato, S Farber, S Kit, S Pollari, SJ Mentch, Swetha Bolusani, T Shlomi, WC Zhang, Y Fu, Z Ser   +55 more
core   +1 more source

Mitochondrial-encoded membrane protein transcripts are pyrimidine-rich while soluble protein transcripts and ribosomal RNA are purine-rich

BMC Genomics, 2005
Background Eukaryotic organisms contain mitochondria, organelles capable of producing large amounts of ATP by oxidative phosphorylation. Each cell contains many mitochondria with many copies of mitochondrial DNA in each organelle.
Samuels David C, Rathi Anand, Bradshaw Patrick C   +2 more
doaj   +1 more source

De novo nucleotide biosynthetic pathway and cancer

Genes and Diseases, 2023
De novo nucleotide biosynthetic pathway is a highly conserved and essential biochemical pathway in almost all organisms. Both purine nucleotides and pyrimidine nucleotides are necessary for cell metabolism and proliferation.
Jie Chen, Siqi Yang, Yingge Li, Xu Ziwen, Pingfeng Zhang, Qibin Song, Yi Yao, Huadong Pei   +7 more
doaj   +1 more source

Can adenine nucleotides predict primary nonfunction of the human liver homograft? [PDF]

, 1994
Sixty-eight primary liver grafts were analyzed to see whether adenine nucleotides (AN: ATP, ADP, and AMP) or purine catabolites (PC: adenosine, inosine, hypoxanthine, and xanthine) of tissue or effluent can predict primary graft nonfunction.
Bronsther, O, Fujita, S, Hamamoto, I, Irish, W, Nakamura, K, Starzl, TE, Takaya, S, Todo, S, Van Gulik, TM   +8 more
core   +1 more source

Efficient Biocatalytic Synthesis of Dihalogenated Purine Nucleoside Analogues Applying Thermodynamic Calculations [PDF]

, 2020
The enzymatic synthesis of nucleoside analogues has been shown to be a sustainable and efficient alternative to chemical synthesis routes. In this study, dihalogenated nucleoside analogues were produced by thermostable nucleoside phosphorylases in ...
Giessmann, Robert T., Kaspar, Felix, Klare, Hendrik F. T., Kurreck, Jens, Neubauer, Peter, Paulick, Katharina, Röhrs, Viola, Wagner, Anke, Westarp, Sarah, Yehia, Heba   +9 more
core   +1 more source

Purine metabolism in the light of aerobic and anaerobic capacity of female boxers

Central European Journal of Sport Sciences and Medicine, 2020
The aim of the work was to assess the intensity of purine nucleotide degradation during maximum physical exercise. 5 elite female boxers were the subject of the study.
Katarzyna Domaszewska, Piotr Szewczyk, Jakub Kryściak, Edyta Michalak, Tomasz Podgórski   +4 more
doaj   +1 more source