Results 151 to 160 of about 1,272,650 (214)

Quantifying Heteromer Partitioning Reveals Inflammation‐Dependent Redistribution of Microglial Adenosine A2A and Cannabinoid CB2 Receptors

Glia, Volume 74, Issue 9, September 2026.
Proinflammatory activation reorganizes microglial A2A and CB2 receptors, promoting their incorporation into stable heteromers and blocking agonist‐induced redistribution. The results reveal those heteromers as potential therapeutic targets in inflammatory contexts.
Rafael Franco, Jaume Lillo, Christian Griñán‐Ferré, Mercè Pallàs, Rafael Rivas‐Santisteban   +4 more
wiley   +1 more source

Opioid Exposure Induces the Expression of the Purinergic Receptor <i>P2RY11</i> in Human Nociceptors. [PDF]

Cells
Demeter JB, McNally SD, Koch MR, Thiyagarajan S, Montoya JA, Vega L, Abboud P, Alles SRA, Ehsanian R, de la Peña JBI.   +9 more
europepmc   +1 more source

Deletion of Astrocytic TNFR1 Attenuates Hyperexcitability and Initiation of Epileptogenesis

Glia, Volume 74, Issue 9, September 2026.
Inducible, astrocyte‐specific deletion of TNFR1 reduces basal EEG spectral power. Loss of astrocytic TNFR1 attenuates acute seizure activity in two distinct experimental models of epilepsy. Deletion of TNFR1 in astrocytes limits epilepsy development and hippocampal pathology in a mouse model of temporal lobe epilepsy with hippocampal sclerosis ...
Lukas Henning, Ioannis Zalachoras, Giovanni Carriero, Gerald Seifert, Peter Bedner, Christian Steinhäuser, Andrea Volterra   +6 more
wiley   +1 more source

Cell Death in Neurodegenerative Diseases: Molecular Mechanisms and Therapeutic Targets

MedComm, Volume 7, Issue 9, September 2026.
Regulated cell death pathways, including apoptosis, necroptosis, pyroptosis, ferroptosis, and autophagy‐dependent cell death, interact with mitochondrial dysfunction, proteostasis failure, lysosomal stress, glial remodeling, and neuroinflammation across major neurodegenerative diseases.
Tianjiao Li, Qian Zhang, Yichen Wu, Ruixue Huang   +3 more
wiley   +1 more source

Elimination of Senescent Macrophages by Purinergic Receptor P2RX7 Antagonist to Safeguard Against Kidney Injury and Aging. [PDF]

Int J Biol Sci
Tang L, Yang L, Zhang R, Li J, Guo F, Ye H, Zhou P, Liu F, Ma L, Fu P.   +9 more
europepmc   +1 more source

Corrigendum to "New paradigms in purinergic receptor ligand discovery" [Neuropharmacology 230 (2023) 109503]. [PDF]

Neuropharmacology, 2023
Jacobson KA, Pradhan B, Wen Z, Pramanik A.   +3 more
europepmc   +1 more source

DAMPs, PAMPs, and Alarmins: From Mechanism to Therapy

MedComm, Volume 7, Issue 9, September 2026.
This review synthesizes the expanding biology of PAMPs and DAMPs, from their molecular sources and sensing mechanisms to regulatory networks that govern inflammation and homeostasis. Spanning from classical immune activation to trained immunity and interorgan communication, we highlight the interplay between PAMPs and DAMPs and their context‐dependent ...
Xuanxuan Yu, Yuqin Jin, Baochao Li, Jie Deng, Yiwen Zhou, Jinglun Zhang, Huang Li   +6 more
wiley   +1 more source

The purinergic receptor P2X4R impacts lipid droplet size in fatty liver by stimulating macroautophagy. [PDF]

JHEP Rep
Pebrier T, Garcin I, Fayol O, Muthukulavan M, Doignon I, Bouzhir L, Gautherot J, Cauchois F, Dellis O, Le Guilcher C, Guettier C, Merlen G, Tordjmann T.   +12 more
europepmc   +1 more source

Migraine: Epidemiology, Risk Factors, Pathophysiology, and Treatment

MedComm, Volume 7, Issue 9, September 2026.
Migraine is a highly prevalent, female‐predominant, and disabling brain disorder shaped by genetic susceptibility, hormonal influences, modifiable attack factors, and comorbidity‐related progression. This review integrates current evidence on migraine epidemiology, phase‐specific neurovascular and neuroglial mechanisms, including CGRP signaling and ...
Weiwei Lu, Yuan Zhang, Chen Shi, Yu Tao, Shaoxin Li, Yufang Sun, Fuhai Ji, Dongsheng Jiang, Terrance P. Snutch, Jin Tao   +9 more
wiley   +1 more source

P2Y2 Purinergic Receptor Promotes Trafficking of Hematopoietic Stem/Progenitor Cells (HSPCs). [PDF]

Stem Cell Rev Rep
Adamiak M, Brzezniakiewicz-Janus K, Molenda M, Ratajczak J, Tang Y, Kucia M, Ratajczak MZ.   +6 more
europepmc   +1 more source