Altered purinergic receptor expression in the frontal cortex in schizophrenia. [PDF]
Alnafisah R +7 more
europepmc +1 more source
Graphical summary of post‐mortem brain tissue findings that differ between symptomatic and asymptomatic AD. Current evidence suggests reduced accumulation of Aβ and p‐tau oligomers, particularly at synapses, preserved neuronal and synaptic integrity and metabolic activity and a dynamic profile of glial and immune responses in ASYMAD.
Thiago Guilherme Rêgo Barros +6 more
wiley +1 more source
Possible Roles for Purinergic Receptor P2RX4 in Breast and Prostate Cancers. [PDF]
Ho WHJ, Lam KP.
europepmc +1 more source
Early Regional Microglial Remodelling in the Hippocampus of the AppNL‐G‐F Alzheimer's Model
Microglia undergo profound structural and functional changes during Alzheimer's disease, yet the earliest stages of morphological remodelling that occur prior to amyloid deposition remain poorly defined. Through high‐resolution 3D morphometry in the CA1 region of the hippocampus of AppNL‐G‐F mice, it was found that although microglial numbers and ...
Ryan J. Bevan +4 more
wiley +1 more source
Purinergic Receptor Nanoimmunoamplifiers Potentiate Chemoimmunotherapy Efficacy in Hepatocellular Carcinoma. [PDF]
Zhang J +11 more
europepmc +1 more source
ABSTRACT Sleep deprivation alters metabolic homeostasis and substrate metabolism, but its effect on fat and carbohydrate utilization during exercise is unclear. This study examined the effects of one night of total and partial sleep deprivation on substrate utilization during a maximal fat oxidation test (MFO) in recreationally trained adults.
Marta del Val‐Manzano +5 more
wiley +1 more source
P2 purinergic receptor dysregulation in urologic disease. [PDF]
Maynard JP, Sfanos KS.
europepmc +1 more source
HIF‐Regulated Pannexin‐1 Channel Drives Luminal ATP Accumulation in Kidney Cysts
Autosomal dominant polycystic kidney disease causes progressive cyst enlargement in the kidneys, leading to hypoxia and induction of HIF‐1α. Our study identifies HIF‐1α‐dependent transcriptional upregulation of Pannexin1 (PANX1) in the apical membrane of cyst epithelial cells, promoting ATP release into the cyst lumen.
Kathrin Skoczynski +10 more
wiley +1 more source
eATP sensing by the purinergic receptor PA2072 for allosteric modulation in intracellular c-di-GMP signaling. [PDF]
Zhang Y +18 more
europepmc +1 more source
Correction: ATP purinergic receptor signalling promotes Sca-1 + cell proliferation and migration for vascular remodelling. [PDF]
Cui Y +7 more
europepmc +1 more source

