Results 161 to 170 of about 1,272,650 (214)

Neurocardiology: Brain–Heart Interactions in the Heart

MedComm, Volume 7, Issue 9, September 2026.
The heart and brain maintain systemic homeostasis through bidirectional communication involving neural, biochemical, and mechanical pathways. Dysregulation of these pathways contributes to a spectrum of conditions involving heart–brain interactions, including Takotsubo syndrome, the epileptic heart, stroke–heart syndrome, heart failure, cardiac ...
Wentao Wang, Hao Jia, Han Han, Jiangping Song   +3 more
wiley   +1 more source

Cdk5 modulates orofacial pain through P2X2/3 purinergic receptor-mediated signaling in trigeminal neurons. [PDF]

Front Pharmacol
Sandoval R, Pinto-Pardo N, Duran C, Castro P, Rossi G, González-Billault C, Pertusa M, Madrid R, Coddou C, Utreras E.   +9 more
europepmc   +1 more source

Blocking P2Y2 purinergic receptor prevents the development of lipopolysaccharide-induced acute respiratory distress syndrome. [PDF]

Front Immunol, 2023
Kargarpour Z, Cicko S, Köhler TC, Zech A, Stoshikj S, Bal C, Renner A, Idzko M, El-Gazzar A.   +8 more
europepmc   +1 more source

Non-cell autonomous downregulation of the purinergic receptor P2Y1R promotes neuroprotection after ischemic injury. [PDF]

Front Cell Neurosci
Spagnuolo G, Iacovitti L.
europepmc   +1 more source

Piezo1 Activation Rescues Anabolic Response to Mechanical Loading in Aged Bone via Connexin 43 Hemichannels

Aging Cell, Volume 25, Issue 9, September 2026.
Yoda1‐induced Piezo1 activation enhances Piezo1‐Cx43 interaction upon mechanical stimulation, triggering PI3K‐Akt signaling to drive Cx43 phosphorylation and hemichannel opening. These events elevate PGE2 release, suppress SOST expression in senescent osteocytes, and ultimately enhance bone anabolism on the endosteal surface.
Dezhi Zhao, Jiayue Fu, Han Liu, Shuting Liang, Mingming Song, Aining Zhang, Dong‐en Wang, Qianjin Guo, You Zhang, Jiawei Wu, Huiyun Xu   +10 more
wiley   +1 more source

Cannabinoid and adenosine A2A receptor crosstalk regulates postnatal and adult hippocampal neurogenesis

British Journal of Pharmacology, Volume 183, Issue 18, Page 5440-5457, September 2026.
Background and purpose Adult neurogenesis is a tightly regulated process affected by both cannabinoid receptors (CB1 and CB2) and adenosine 2A (A2A) receptors, both of which modulate neural progenitor cell activity. While emerging evidence suggests an interaction between these neuromodulatory systems, the extent and mechanism of their interplay in ...
Rui S. Rodrigues, Adam Armada‐Moreira, Laura Gómez‐Acero, Filipa F. Ribeiro, Francisco M. Mouro, Ana M. Sebastião, Francisco Ciruela, Ester Aso, Sara Xapelli   +8 more
wiley   +1 more source

Purinergic signalling in skin

, 2002
Purinergic receptors, which bind ATP, are expressed on human cutaneous keratinocytes. Previous work in rat epidermis suggested functional roles of purinergic receptors in the regulation of proliferation, differentiation and apoptosis, for example P2X5 ...
Greig, Aina V. H.
core  

Heart failure‐induced reprogramming of salt‐evoked neurovascular coupling in the rat hypothalamus

The Journal of Physiology, Volume 604, Issue 18, Page 7845-7868, 15 September 2026.
Abstract figure legend In sham rat, hypertonic saline induces activation of the AVP neurons, leading to dendritic AVP release and subsequent V1aR‐mediated PA vasoconstriction resulting in local tissue hypoxia in the SON. In heart failure rat, hypertonic saline similarly induces activation of the AVP neuron leading to dendritic AVP release.
Ranjan K. Roy, Elba Campos Lira, Manuel Bita Ongolo, Jessica A. Filosa, Javier E. Stern   +4 more
wiley   +1 more source

Correction: ATP purinergic receptor signalling promotes Sca-1 ⁺ cell proliferation and migration for vascular remodelling. [PDF]

Cell Commun Signal, 2023
Cui Y, Li C, Zeng X, Wei X, Li P, Cheng J, Xu Q, Yang Y.   +7 more
europepmc   +1 more source

Supracellular contractility in Xenopus embryo epithelia regulated by extracellular ATP and the purinergic receptor P2Y2. [PDF]

J Cell Sci
Joshi SD, Jackson TR, Zhang L, Stuckenholz C, Davidson LA.   +4 more
europepmc   +1 more source