Results 1 to 10 of about 736,547 (297)
Adenosine and P1 receptors: Key targets in the regulation of sleep, torpor, and hibernation [PDF]
Frontiers in Pharmacology, 2023 Sleep, torpor, and hibernation are three distinct hypometabolic states. However, they have some similar physiological features, such as decreased core body temperature and slowing heart rate.
Wei-Xiang Ma +7 more
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P1 receptors and cytokine secretion [PDF]
Purinergic Signalling, 2007 Evidence has accumulated in the last three decades to suggest tissue protection and regeneration by adenosine in multiple different cell types. Adenosine produced in hypoxic or inflamed environments reduces tissue injury and promotes repair by receptor-mediated mechanisms.
M.P. Abbracchio, S. Ceruti
openaire +4 more sources
Computational and Structural Biotechnology Journal, 2023 Purinergic receptors are membrane proteins that regulate numerous cellular functions by catalyzing reactions involving purine nucleotides or nucleosides.
Ri Han +3 more
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Inherited human CARD9 deficiency impairs lymphoid cell, but not fibroblast, IL-17–mediated immunity [PDF]
JCI InsightNearly 100 individuals have been identified who carry deleterious biallelic germline variants in CARD9 and experience life-threatening, invasive fungal infections caused by Ascomycetes but are otherwise resistant to other infectious agents.
Erika Della Mina +12 more
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Adenosine receptors as emerging therapeutic targets for diabetic kidney disease [PDF]
Kidney Research and Clinical Practice, 2022 Diabetic kidney disease (DKD) is now a pandemic worldwide, and novel therapeutic options are urgently required. Adenosine, an adenosine triphosphate metabolite, plays a role in kidney homeostasis through interacting with four types of adenosine receptors
Eun Seon Pak +4 more
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Alzheimer and Purinergic Signaling: Just a Matter of Inflammation?
Cells, 2021 Alzheimer’s disease (AD) is a widespread neurodegenerative pathology responsible for about 70% of all cases of dementia. Adenosine is an endogenous nucleoside that affects neurodegeneration by activating four membrane G protein-coupled receptor subtypes,
Stefania Merighi +5 more
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Purinergic signaling: A gatekeeper of blood-brain barrier permeation
Frontiers in Pharmacology, 2023 This review outlined evidence that purinergic signaling is involved in the modulation of blood-brain barrier (BBB) permeability. The functional and structural integrity of the BBB is critical for maintaining the homeostasis of the brain microenvironment.
Yuemei Wang +6 more
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Medical Sciences Forum, 2022 Triple-negative breast cancer (TNBC), a poor survival cancer has high resistance to therapy, with low-drug efficacy. Adenosine is present in high concentrations in the tumor microenvironment.
Ana Cerquido +4 more
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Regulation of Microglial Functions by Purinergic Mechanisms in the Healthy and Diseased CNS
Cells, 2020 Microglial cells, the resident macrophages of the central nervous system (CNS), exist in a process-bearing, ramified/surveying phenotype under resting conditions.
Peter Illes +4 more
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Presynaptic Purinergic Modulation of the Rat Neuro-Muscular Transmission
Current Issues in Molecular Biology, 2023 ATP, being a well-known universal high-energy compound, plays an important role as a signaling molecule and together with its metabolite adenosine they both attenuate the release of acetylcholine in the neuro-muscular synapse acting through membrane P2 ...
Adel E. Khairullin +2 more
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