Results 31 to 40 of about 736,547 (297)
Purinergic signaling: A new front-line determinant of resistance and susceptibility in leishmaniasis
Biomedical Journal, 2022 Leishmaniasis is a neglected tropical disease that causes several clinical manifestations. Parasites of the genus Leishmania cause this disease. Spread across five continents, leishmaniasis is a particular public health problem in developing countries ...
Mariana Chaves +2 more
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Antiplatelet activity, P2Y₁ and P2Y₁₂ inhibition, and metabolism in plasma of stereoisomers of diadenosine 5',5'″-P¹ ,P⁴-dithio-P²,P³-chloromethylenetetraphosphate. [PDF]
PLoS ONE, 2014 Diadenosine tetraphosphate (Ap4A), a constituent of platelet dense granules, and its P1,P4-dithio and/or P2,P3-chloromethylene analogs, inhibit adenosine diphosphate (ADP)-induced platelet aggregation. We recently reported that these compounds antagonize
Hung Chang +8 more
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The role of purinergic signaling in microglial responses
Stress and Brain, 2021 Microglia, the primary immune cells in the central nervous system (CNS), are key to the maintenance of homeostasis in the brain parenchyma. In the intact brain, microglia continuously survey the microenvironment with ramified processes.
Yaling Hu, Zhihua Gao
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Role of adenosine A2a receptor in cancers and autoimmune diseases
Immunity, Inflammation and Disease, 2023 Adenosine receptors are P1 class of purinergic receptors that belong to G protein‐coupled receptors. There are 4 subtypes of adenosine receptors, namely A1, A2A, A2B, and A3. A2AR has a high affinity for the ligand adenosine.
Hongling Ye +5 more
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Purinergic signaling in the male reproductive tract
Frontiers in Endocrinology, 2022 Purinergic receptors are ubiquitously expressed throughout the body and they participate in the autocrine and paracrine regulation of cell function during normal physiological and pathophysiological conditions.
Larissa Berloffa Belardin +4 more
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Pharmacological ResearchMajor depressive disorder (MDD) is a mental illness characterized primarily by persistent low mood and anhedonia. Traditional monoamine antidepressants have not achieved entirely satisfactory clinical efficacy.
Xing-Ying Ren +4 more
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() The sequences of the wt P1, (-1C)-P1, (-3m)-P1 and (-5U)-P1 duplexes
, 2011 Copyright information:Taken from "Thermodynamics and kinetics for base-pair opening in the P1 duplex of the group I ribozyme"Nucleic Acids Research 2007;35(9):2965-2974.Published online 16 Apr 2007PMCID:PMC1891724.© 2007 The Author(s) The numbering of ...
Joon-Hwa Lee (29631) +1 more
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Frontiers in Pharmacology, 2018 Cytokine-induced killer (CIK) cells, a heterogeneous T cell population obtained by in vitro differentiation of peripheral blood mononuclear cells (PBMC), represent a promising immunological approach in cancer.
Alberto L. Horenstein +8 more
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Molecular Oncology, EarlyView.In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera +11 more
wiley +1 more source
Purinergic Receptors of the Central Nervous System: Biology, PET Ligands, and Their Applications
Molecular Imaging, 2020 Purinergic receptors play important roles in central nervous system (CNS). These receptors are involved in cellular neuroinflammatory responses that regulate functions of neurons, microglial and astrocytes.
Hamideh Zarrinmayeh PhD +1 more
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