Results 181 to 190 of about 2,316,796 (350)

Corrigendum to "New paradigms in purinergic receptor ligand discovery" [Neuropharmacology 230 (2023) 109503]. [PDF]

Neuropharmacology, 2023
Jacobson KA, Pradhan B, Wen Z, Pramanik A.   +3 more
europepmc   +1 more source

Identification of Amino Acid Residues Contributing to the ATP-binding Site of a Purinergic P2X Receptor [PDF]

, 2000
Lin‐Hua Jiang, François Rassendren, Annmarie Surprenant, R. Alan North   +3 more
openalex   +1 more source

Coronary Microvascular Dysfunction in Ischaemic Heart Disease: Lessons From Large Animal Models

Basic &Clinical Pharmacology &Toxicology, Volume 137, Issue 2, August 2025.
ABSTRACT The coronary microvasculature is principally responsible for matching coronary blood flow to myocardial demand of oxygen and nutrients. Short‐term control of coronary blood flow is achieved via alterations in coronary microvascular tone, whereas long‐term control of coronary flow also involves remodelling of the coronary microvasculature ...
Oana Sorop, J. van de Wouw, Daphne Merkus, Dirk J. Duncker   +3 more
wiley   +1 more source

Modulation of Interleukin-1β and Tumor Necrosis Factor α Signaling by P2 Purinergic Receptors in Human Fetal Astrocytes [PDF]

, 2000
Judy S. H. Liu, Gareth John, Andrew G. Sikora, S C Lee, Celia F. Brosnan   +4 more
openalex   +1 more source

Nimodipine reduces microglial activation in vitro as evidenced by morphological phenotype, phagocytic activity and high‐throughput RNA sequencing

British Journal of Pharmacology, Volume 182, Issue 16, Page 3800-3817, August 2025.
Background and Purpose Nimodipine, an L‐type voltage‐gated calcium channel blocker, is an approved cerebral vasorelaxant. We hypothesized that nimodipine attenuates the pro‐inflammatory shift in microglial phenotypes. Here, we analysed the effects of nimodipine on morphological and functional microglial phenotypes as well as their transcriptomic ...
István Pesti, Valentin Varga, Erda Qorri, Rita Frank, Diana Kata, Krisztián Vinga, Péter Archibald Szarvas, Ákos Menyhárt, Károly Gulya, Ferenc Bari, Eszter Farkas   +10 more
wiley   +1 more source

Blocking P2Y2 purinergic receptor prevents the development of lipopolysaccharide-induced acute respiratory distress syndrome. [PDF]

Front Immunol, 2023
Kargarpour Z, Cicko S, Köhler TC, Zech A, Stoshikj S, Bal C, Renner A, Idzko M, El-Gazzar A.   +8 more
europepmc   +1 more source

P2 purinergic receptors of human eosinophils: characterization and coupling to oxygen radical production [PDF]

, 2000
Davide Ferrari, Marco Idzko, Stefan Dichmann, Daniela Purlis, Christian Virchow, Johannes Norgauer, Paola Chiozzi, Francesco Di Virgilio, Werner Luttmann   +8 more
openalex   +1 more source

The human colon: Evidence for degenerative changes during aging and the physiological consequences

Neurogastroenterology &Motility, Volume 37, Issue 8, August 2025.
Reduced nociceptor innervation can explain diminished abdominal pain among the elderly. Degenerative changes occur within the colon wall, especially ascending colon. Mechanisms may include senescence‐like activity and inflammaging. Constipation is more likely to occur during age‐related challenges affecting functions of the bowel that now have reduced ...
Nicholas Baidoo, Gareth J. Sanger
wiley   +1 more source

Sex-specific effect of P2Y₂ purinergic receptor on glucose metabolism during acute inflammation. [PDF]

Front Endocrinol (Lausanne), 2023
Ulbricht RJ, Rivas CA, Marino H, Snyder E, James D, Makhloufi J, Johnson N, Zimmerman S, Wang J.   +8 more
europepmc   +1 more source

Adenosine triphosphate stimulates inositol phospholipid metabolism and prostacyclin formation in adrenal medullary endothelial cells by means of P2-purinergic receptors.

, 1987
Erik Forsberg, G Feuerstein, Esther Shohami, Harvey B. Pollard   +3 more
openalex   +1 more source